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Socs2 Gene Detail
Summary
  • Symbol
    Socs2
  • Name
    suppressor of cytokine signaling 2
  • Synonyms
    CIS2, Cish2, cytokine-inducible SH2 protein 2, D130043N08Rik, JAB, SOCS-2, SSI-2, STAT-induced STAT inhibitor 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201787
    NCBI Gene: 216233
  • Gene Overview
    MyGene.info: SOCS2
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:95385362-95417180 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 49.35 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    175 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1201787
protein coding gene Chr10:95383903-95417253 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017668
protein coding gene Chr10:96937501-96973758 (-)
A/J MGP_AJ_G0017647
protein coding gene Chr10:93528011-93558876 (-)
AKR/J MGP_AKRJ_G0017605
protein coding gene Chr10:96199180-96236042 (-)
BALB/cJ MGP_BALBcJ_G0017610
protein coding gene Chr10:93794557-93824412 (-)
C3H/HeJ MGP_C3HHeJ_G0017433
protein coding gene Chr10:96199525-96231133 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018067
protein coding gene Chr10:100150125-100185147 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015748
protein coding gene Chr10:89086325-89118747 (-)
CAST/EiJ MGP_CASTEiJ_G0016998
protein coding gene Chr10:96209855-96244430 (-)
CBA/J MGP_CBAJ_G0017402
protein coding gene Chr10:104278647-104312833 (-)
DBA/2J MGP_DBA2J_G0017508
protein coding gene Chr10:92619652-92650802 (-)
FVB/NJ MGP_FVBNJ_G0017500
protein coding gene Chr10:91864714-91898012 (-)
LP/J MGP_LPJ_G0017582
protein coding gene Chr10:97560945-97597764 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017531
protein coding gene Chr10:105462343-105494616 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018104
protein coding gene Chr10:96107136-96138829 (-)
PWK/PhJ MGP_PWKPhJ_G0016779
protein coding gene Chr10:92724080-92757281 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016567
protein coding gene Chr10:94940896-94972139 (-)
WSB/EiJ MGP_WSBEiJ_G0017057
protein coding gene Chr10:96078253-96116025 (-)



Homology
more
  • Human Ortholog
    SOCS2, suppressor of cytokine signaling 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SOCS2, suppressor of cytokine signaling 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CIS2, Cish2, SOCS-2, SSI2, SSI-2, STATI2
  • Links
    NCBI Gene ID: 8835
    neXtProt AC: NX_O14508
    UniProt: O14508

  • Chr Location
    12q22; chr12:93569822-93626236 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    52 phenotypes from 4 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    65 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutations in this gene cause accelerated postnatal growth. Homozygotes for a targeted mutation also show increased bone growth, enlargement of most organs, collagen deposition in the skin and some ducts and vessels, lower major urinary protein levels, and elevated IGF-I mRNA levels in some tissues.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020027 Ensembl Gene Model | MGI Sequence Detail 31819 C57BL/6J ±  kb
    transcript ENSMUST00000139210 Ensembl | MGI Sequence Detail 4242 Not Applicable  
    polypeptide ENSMUSP00000121305 Ensembl | MGI Sequence Detail 201 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 20

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-10702, MGI:2143636, MGI:2143807, MGI:96077
    References
    more
    • Summaries
      All 135
      Developmental Gene Expression 10
      Gene Ontology 10
      Phenotypes 65
    • Earliest
      J:220665 Bradford GE, Selection for litter size in mice in the presence and absence of gonadotropin treatment. Genetics. 1968 Feb;58(2):283-95
    • Latest
      J:257927 Fairchild CL, et al., RBX2 maintains final retinal cell position in a DAB1-dependent and -independent fashion. Development. 2018 Feb 2;145(3)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory