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Socs2 Gene Detail
Summary
  • Symbol
    Socs2
  • Name
    suppressor of cytokine signaling 2
  • Synonyms
    CIS2, Cish2, cytokine-inducible SH2 protein 2, D130043N08Rik, JAB, SOCS-2, SSI-2, STAT-induced STAT inhibitor 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201787
    NCBI Gene: 216233
  • Gene Overview
    MyGene.info: SOCS2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:95385362-95417180 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      31819 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 49.35 cM
  • Mapping Data
    10 experiments
Homology
more
  • Human Ortholog
    SOCS2, suppressor of cytokine signaling 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SOCS2, suppressor of cytokine signaling 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CIS2, Cish2, SOCS-2, SSI2, SSI-2, STATI2
  • Links
    NCBI Gene ID: 8835
    neXtProt AC: NX_O14508
    UniProt: O14508

  • Chr Location
    12q22; chr12:93569822-93626236 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    52 phenotypes from 4 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    62 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this gene cause accelerated postnatal growth. Homozygotes for a targeted mutation also show increased bone growth, enlargement of most organs, collagen deposition in the skin and some ducts and vessels, lower major urinary protein levels, and elevated IGF-I mRNA levels in some tissues.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000028424 VEGA Gene Model | MGI Sequence Detail 31819 C57BL/6J ±  kb
    transcript OTTMUST00000070434 VEGA | MGI Sequence Detail 4242 Not Applicable  
    polypeptide OTTMUSP00000035899 VEGA | MGI Sequence Detail 201 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      175 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 18

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-10702, MGI:2143636, MGI:2143807, MGI:96077
    References
    more
    • Summaries
      All 130
      Developmental Gene Expression 9
      Gene Ontology 9
      Phenotypes 62
    • Earliest
      J:220665 Bradford GE, Selection for litter size in mice in the presence and absence of gonadotropin treatment. Genetics. 1968 Feb;58(2):283-95
    • Latest
      J:259177 Basrai HS, et al., Suppressor of Cytokine Signalling 2 (SOCS2) Regulates Numbers of Mature Newborn Adult Hippocampal Neurons and Their Dendritic Spine Maturation. Cell Mol Neurobiol. 2017 Jul;37(5):899-909

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory