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Map6
Gene Detail
 Symbol
Name
ID
Map6
microtubule-associated protein 6
MGI:1201690
Synonyms 2810411E12Rik, F-STOP, Mtap6, STOP
Feature Type protein coding gene
Genetic Map
Chromosome 7
54.05 cM, cytoband E2-F1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:99267447-99337136 bp, + strand
From VEGA annotation of GRCm38

  69690 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7850  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Map6

Human
homologs
Human Homolog MAP6, microtubule-associated protein 6
NCBI Gene ID 4135
neXtProt AC  NX_Q96JE9
Human Synonyms  MTAP6, N-STOP, STOP
Human Chr (Location)  11q13.5; chr11:75586918-75668730 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(6) Targeted(4)
Incidental mutations (data from APF )
 
Mice homozygous for a targeted null mutation are devoid of cold-stable microtubules, and exhibit impaired synaptic plasticity, associated with severe behavioral abnormalities that are specifically ameliorated by long-term administration of neuroleptics.
 
Human Diseases Modeled Using Mouse Map6 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Map6 interacts with 177 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process dendrite morphogenesis, lysosome localization, ...
Component cytoplasm, cytoskeleton, ...
Function calmodulin binding, microtubule binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (65)    Tissues (11)    Images (23)
Theiler Stages: 23
Assay TypeResults
RNA in situ 65
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) Genomic(4) cDNA(11)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000031150 (Evidence)
Ensembl Gene ModelENSMUSG00000055407 (Evidence)
Entrez Gene17760 (Evidence)
DFCITC1577422, TC1593555, TC1611603, TC1632676
DoTSDT.484733, DT.91291795, DT.94402578
NIA Mouse Gene IndexU008437
Consensus CDS ProjectCCDS21479.1, CCDS40029.1
International Mouse Knockout Project StatusMap6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031150 VEGA Gene Model | MGI Sequence Detail 69690 C57BL/6J ±  kb
transcript OTTMUST00000077163 VEGA | MGI Sequence Detail 3430 Not Applicable 
polypeptide OTTMUSP00000040747 VEGA | MGI Sequence Detail 906 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(12) UniProt(2)
Polymorphisms SNPs within 2kb(863 from dbSNP Build 137)    SNPs within 2kb including multiple locations(869)
Protein-related
information
ResourceIDDescription
InterPro IPR024963 STOP/FAM154
InterPro IPR007882 STOP/MAP6
Protein Ontology PR:000010147 microtubule-associated protein 6
References (Earliest) J:46215 Denarier E, et al., Genomic structure and chromosomal mapping of the mouse STOP gene (Mtap6). Biochem Biophys Res Commun. 1998 Feb 24;243(3):791-6
(Latest) J:184340 Fournet V, et al., The deletion of STOP/MAP6 protein in mice triggers highly altered mood and impaired cognitive performances. J Neurochem. 2012 Apr;121(1):99-114
All references(48)
Disease annotation references (1)
Other
accession IDs
MGI:2152340

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory