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Map6 Gene Detail
Summary
  • Symbol
    Map6
  • Name
    microtubule-associated protein 6
  • Synonyms
    2810411E12Rik, F-STOP, Mtap6, STOP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201690
    NCBI Gene: 17760
  • Gene Overview
    MyGene.info: MAP6
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr7:99267447-99337137 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      69691 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 54.05 cM, cytoband E2-F1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MAP6, microtubule associated protein 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MAP6, microtubule associated protein 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MAP6-N, MTAP6, N-STOP, STOP
  • Links
    NCBI Gene ID: 4135
    neXtProt AC: NX_Q96JE9
    UniProt: Q96JE9

  • Chr Location
    11q13.5; chr11:75586914-75671108 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Map6 mouse models

Human Disease Mouse Models
      
IDs
 View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 1 allele in 2 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Gene trapped
    6
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Map6
  • Incidental Mutations
    APF , CvDC
  • Find Mice (IMSR)
    5 strains or lines available
Mice homozygous for a targeted null mutation are devoid of cold-stable microtubules, and exhibit impaired synaptic plasticity, associated with severe behavioral abnormalities that are specifically ameliorated by long-term administration of neuroleptics.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    25
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    65
  • Tissues
    11
  • cDNA Data
    11
  • Literature Summary
    3
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031150 VEGA Gene Model | MGI Sequence Detail 69691 C57BL/6J ±  kb
transcript OTTMUST00000077163 VEGA | MGI Sequence Detail 3431 Not Applicable  
polypeptide OTTMUSP00000040747 VEGA | MGI Sequence Detail 906 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    854 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    Genomic 4
    cDNA 13

    Microarray probesets 4
Other
Accession IDs
less
MGI:2152340
References
more
  • Summaries
    All 59
    Developmental Gene Expression 3
    Diseases 2
    Gene Ontology 6
    Phenotypes 26
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:250438 Tortosa E, et al., Dynamic Palmitoylation Targets MAP6 to the Axon to Promote Microtubule Stabilization during Neuronal Polarization. Neuron. 2017 May 17;94(4):809-825.e7
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
07/31/2018
MGI 6.12 		The Jackson Laboratory