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Map6
Gene Detail
Symbol

Name
ID
Map6
microtubule-associated protein 6
MGI:1201690
Synonyms
2810411E12Rik, F-STOP, Mtap6, STOP
Feature Type
protein coding gene
Genetic Map
Chromosome 7
54.05 cM, cytoband E2-F1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:99267447-99337136 bp, + strand
From VEGA annotation of GRCm38

  69690 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7850  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

HCOP human homology predictions: MAP6
Gene Tree: Map6

Human
homologs
MAP6, microtubule-associated protein 6
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4135
neXtProt AC: NX_Q96JE9

Human Synonyms: MAP6-N, MTAP6, N-STOP, STOP

Human Chr (Location): 11q13.5; chr11:75586914-75668730 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(6) Targeted(4)
Incidental mutations (data from APF , CvDC )
 
Mice homozygous for a targeted null mutation are devoid of cold-stable microtubules, and exhibit impaired synaptic plasticity, associated with severe behavioral abnormalities that are specifically ameliorated by long-term administration of neuroleptics.
 
Human Diseases Modeled in Mice Using Map6 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Map6 interacts with 177 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process dendrite morphogenesis, lysosome localization, ...
Component cytoplasm, cytoskeleton, ...
Function calmodulin binding, microtubule binding
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (65)    Tissues (11)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 65
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase map6 ; ZFIN map6a    NEW 
Molecular
reagents
All nucleic(15) Genomic(4) cDNA(11)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000031150 (Evidence)
Ensembl Gene Model ENSMUSG00000055407 (Evidence)
Entrez Gene 17760 (Evidence)
DFCI TC1577422, TC1593555, TC1611603, TC1632676
DoTS DT.484733, DT.91291795, DT.94402578
NIA Mouse Gene Index U008437
Consensus CDS Project CCDS21479.1, CCDS40029.1
International Mouse Phenotyping Consortium Status Map6
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031150 VEGA Gene Model | MGI Sequence Detail 69690 C57BL/6J ±  kb
transcript OTTMUST00000077163 VEGA | MGI Sequence Detail 3430 Not Applicable 
polypeptide OTTMUSP00000040747 VEGA | MGI Sequence Detail 906 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(13) UniProt(2)
Polymorphisms
SNPs within 2kb(863 from dbSNP Build 137)    SNPs within 2kb including multiple locations(869)
Protein-related
information
ResourceIDDescription
InterPro IPR024963 MAP6/FAM154
InterPro IPR007882 Microtubule-associated protein 6
Protein Ontology PR:000010147 microtubule-associated protein 6
References
(Earliest) J:46215 Denarier E, et al., Genomic structure and chromosomal mapping of the mouse STOP gene (Mtap6). Biochem Biophys Res Commun. 1998 Feb 24;243(3):791-6
(Latest) J:223036 Deloulme JC, et al., Microtubule-associated protein 6 mediates neuronal connectivity through Semaphorin 3E-dependent signalling for axonal growth. Nat Commun. 2015;6:7246
All references(48)
Disease annotation references (1)
Other
accession IDs
MGI:2152340

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory