Map6
Gene Detail

Symbol Name ID

Map6 microtubule-associated protein 6 MGI:1201690

Synonyms

2810411E12Rik, F-STOP, Mtap6, STOP

Feature Type

protein coding gene

Genetic Map

Chromosome 7

54.05 cM, cytoband E2-F1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr7:99267447-99337136 bp, + strand From VEGA annotation of GRCm38   69690 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7850  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Map6

Human homologs

Human Homolog		MAP6, microtubule-associated protein 6
NCBI Gene ID		4135
neXtProt AC		NX_Q96JE9
Human Synonyms		MTAP6, N-STOP, STOP
Human Chr (Location)		11q13.5; chr11:75297963-75379479 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(10) : Targeted(4) Gene trapped(6)
 

Mice homozygous for a targeted null mutation are devoid of cold-stable microtubules, and exhibit impaired synaptic plasticity, associated with severe behavioral abnormalities that are specifically ameliorated by long-term administration of neuroleptics.

 
Human Diseases Modeled Using Mouse Map6 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	negative regulation of microtubule depolymerization
Component	cytoplasm, cytoskeleton, ...
Function	calmodulin binding, microtubule binding

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (65)    Tissues (11)    Images (23)
Theiler Stages: 23

Assay Type	Results
RNA in situ	65

cDNA source data(9)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(15) Genomic(4) cDNA(11)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000031150 (Evidence)
Ensembl Gene Model	ENSMUSG00000055407 (Evidence)
Entrez Gene	17760 (Evidence)
DFCI	TC1577422, TC1593555, TC1611603, TC1632676
DoTS	DT.484733, DT.91291795, DT.94402578
NIA Mouse Gene Index	U008437
Consensus CDS Project	CCDS21479.1, CCDS40029.1
International Mouse Knockout Project Status	Map6

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031150	VEGA Gene Model | MGI Sequence Detail	69690	C57BL/6J
transcript	OTTMUST00000077163	VEGA | MGI Sequence Detail	3430	Not Applicable
polypeptide	OTTMUSP00000040747	VEGA | MGI Sequence Detail	906	Not Applicable

All sequences(47) RefSeq(6) UniProt(2)

Polymorphisms

SNPs(344 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007882	Stable tubule-only polypeptide (STOP)
InterPro	IPR024963	STOP/FAM154
Protein Ontology	PR:000010147	microtubule-associated protein 6

References

(Earliest) J:46215 Denarier E, et al., Genomic structure and chromosomal mapping of the mouse STOP gene (Mtap6). Biochem Biophys Res Commun. 1998 Feb 24;243(3):791-6
(Latest) J:184340 Fournet V, et al., The deletion of STOP/MAP6 protein in mice triggers highly altered mood and impaired cognitive performances. J Neurochem. 2012 Apr;121(1):99-114
All references(48)

Other accession IDs

MGI:2152340