Map6
Gene Detail

Symbol

Name
ID

Map6
microtubule-associated protein 6
MGI:1201690

Synonyms

2810411E12Rik, F-STOP, Mtap6, STOP

Feature Type

protein coding gene

Genetic Map

Chromosome 7
54.05 cM, cytoband E2-F1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr7:99267447-99337136 bp, + strand From VEGA annotation of GRCm38   69690 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:7850  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Map6

Human
homologs

Human Homolog		MAP6, microtubule-associated protein 6
NCBI Gene ID		4135
neXtProt AC		NX_Q96JE9
Human Synonyms		MAP6-N, MTAP6, N-STOP, STOP
Human Chr (Location)		11q13.5; chr11:75586918-75668730 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(10) : Gene trapped(6) Targeted(4)
Incidental mutations (data from APF )
 

Mice homozygous for a targeted null mutation are devoid of cold-stable microtubules, and exhibit impaired synaptic plasticity, associated with severe behavioral abnormalities that are specifically ameliorated by long-term administration of neuroleptics.

 
Human Diseases Modeled in Mice Using Map6 (1)    Mutations Annotated to Human Diseases (1)   

Interactions

Map6 interacts with 177 markers (Mir7-1, Mir7-2, Mir7b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (12 annotations)

Process	dendrite morphogenesis, lysosome localization, ...
Component	cytoplasm, cytoskeleton, ...
Function	calmodulin binding, microtubule binding

External Resources: FuncBase

Expression

Literature Summary: (1 records)

Data Summary: Results (65)    Tissues (11)    Images (23)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	65

cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(15) Genomic(4) cDNA(11)
Microarray probesets(4)

Other database
links

VEGA Gene Model	OTTMUSG00000031150 (Evidence)
Ensembl Gene Model	ENSMUSG00000055407 (Evidence)
Entrez Gene	17760 (Evidence)
DFCI	TC1611603, TC1632676, TC1577422, TC1593555
DoTS	DT.94402578, DT.91291795, DT.484733
NIA Mouse Gene Index	U008437
Consensus CDS Project	CCDS21479.1, CCDS40029.1
International Mouse Knockout Project Status	Map6

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031150	VEGA Gene Model | MGI Sequence Detail	69690	C57BL/6J
transcript	OTTMUST00000077163	VEGA | MGI Sequence Detail	3430	Not Applicable
polypeptide	OTTMUSP00000040747	VEGA | MGI Sequence Detail	906	Not Applicable

All sequences(53) RefSeq(12) UniProt(2)

Polymorphisms

SNPs within 2kb(863 from dbSNP Build 137)    SNPs within 2kb including multiple locations(869)

Protein-related
information

Resource	ID	Description
InterPro	IPR024963	STOP/FAM154
InterPro	IPR007882	STOP/MAP6
Protein Ontology	PR:000010147	microtubule-associated protein 6

References

(Earliest) J:46215 Denarier E, et al., Genomic structure and chromosomal mapping of the mouse STOP gene (Mtap6). Biochem Biophys Res Commun. 1998 Feb 24;243(3):791-6
(Latest) J:184340 Fournet V, et al., The deletion of STOP/MAP6 protein in mice triggers highly altered mood and impaired cognitive performances. J Neurochem. 2012 Apr;121(1):99-114
All references(48)
Disease annotation references (1)

Other
accession IDs

MGI:2152340