About   Help   FAQ
Nlk Gene Detail
Summary
  • Symbol
    Nlk
  • Name
    nemo like kinase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1201387
    NCBI Gene: 18099
  • Gene Overview
    MyGene.info: NLK
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:78567168-78697373 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 46.74 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    454 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1201387
protein coding gene Chr11:78567168-78697595 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018788
protein coding gene Chr11:79588795-79732641 (-)
A/J MGP_AJ_G0018755
protein coding gene Chr11:76543694-76676785 (-)
AKR/J MGP_AKRJ_G0018725
protein coding gene Chr11:78845553-78975655 (-)
BALB/cJ MGP_BALBcJ_G0018728
protein coding gene Chr11:76942669-77076339 (-)
C3H/HeJ MGP_C3HHeJ_G0018542
protein coding gene Chr11:78898048-79030513 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019180
protein coding gene Chr11:82061696-82201476 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016815
protein coding gene Chr11:73508760-73640319 (-)
CAST/EiJ MGP_CASTEiJ_G0018097
protein coding gene Chr11:79348127-79480777 (-)
CBA/J MGP_CBAJ_G0018513
protein coding gene Chr11:85676418-85806328 (-)
DBA/2J MGP_DBA2J_G0018621
protein coding gene Chr11:76112906-76247814 (-)
FVB/NJ MGP_FVBNJ_G0018610
protein coding gene Chr11:75701268-75839312 (-)
LP/J MGP_LPJ_G0018691
protein coding gene Chr11:80105870-80256131 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018637
protein coding gene Chr11:86028330-86159863 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019220
protein coding gene Chr11:79097761-79234764 (-)
PWK/PhJ MGP_PWKPhJ_G0017867
protein coding gene Chr11:76910080-77042209 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017658
protein coding gene Chr11:78707163-78842727 (-)
WSB/EiJ MGP_WSBEiJ_G0018149
protein coding gene Chr11:78928881-79065135 (-)



Homology
more
  • Human Ortholog
    NLK, nemo like kinase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NLK, nemo like kinase
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 51701
    neXtProt AC: NX_Q9UBE8
    UniProt: Q9UBE8

  • Chr Location
    17q11.2; chr17:28042647-28205140 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 88836
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: NLK
  • Gene Tree
    Nlk
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 4 alleles in 6 genetic backgrounds
    2 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation die either during late gestation or around 4-6 weeks, depending on background. Long survivors exhibit growth retardation, neurological abnormalities, and aberrant differentiation of bone marrow stromal cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000017376 Ensembl Gene Model | MGI Sequence Detail 130206 C57BL/6J ±  kb
    transcript ENSMUST00000142739 Ensembl | MGI Sequence Detail 4444 Not Applicable  
    polypeptide ENSMUSP00000119345 Ensembl | MGI Sequence Detail 527 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 61
      cDNA 61

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2144078
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 6
      Gene Ontology 9
      Phenotypes 24
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:240646 Xing L, et al., Correlated evolution between CK1delta Protein and the Serine-rich Motif Contributes to Regulating the Mammalian Circadian Clock. J Biol Chem. 2017 Jan 06;292(1):161-171

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory