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Nlk
Gene Detail
Symbol

Name
ID
Nlk
nemo like kinase
MGI:1201387
Feature Type
protein coding gene
Genetic Map
Chromosome 11
46.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:78567168-78697373 bp, - strand
From VEGA annotation of GRCm38

  130206 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:88836  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Nlk

Human
homologs
Human Homolog NLK, nemo-like kinase
NCBI Gene ID 51701
neXtProt AC  NX_Q9UBE8
Human Chr (Location)  17q11.2; chr17:28041983-28196381 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(77) : Gene trapped(72) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation die either during late gestation or around 4-6 weeks, depending on background. Long survivors exhibit growth retardation, neurological abnormalities, and aberrant differentiation of bone marrow stromal cells.
 
Interactions
Nlk interacts with 407 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process intracellular signal transduction, MAPK cascade, ...
Component cytoplasm, nucleus
Function ATP binding, kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (52)    Tissues (37)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
RNA in situ 36
Northern blot 12
cDNA source data(59)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(60) cDNA(60)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000000149 (Evidence)
Ensembl Gene ModelENSMUSG00000017376 (Evidence)
Entrez Gene18099 (Evidence)
UniGene9001
DFCITC1750265, TC1577065
DoTSDT.91329044, DT.101372250
EC2.7.11.24
Consensus CDS ProjectCCDS25113.2
International Mouse Knockout Project StatusNlk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000000149 VEGA Gene Model | MGI Sequence Detail 130206 C57BL/6J ±  kb
transcript OTTMUST00000000472 VEGA | MGI Sequence Detail 4444 Not Applicable 
polypeptide OTTMUSP00000000207 VEGA | MGI Sequence Detail 527 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(454 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003527 Mitogen-activated protein (MAP) kinase, conserved site
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000011259 serine/threonine-protein kinase NLK
References
(Earliest) J:45651 Brott BK, et al., Nlk is a murine protein kinase related to Erk/MAP kinases and localized in the nucleus. Proc Natl Acad Sci U S A. 1998 Feb 3;95(3):963-8
(Latest) J:198661 Ju H, et al., Polyglutamine disease toxicity is regulated by Nemo-like kinase in spinocerebellar ataxia type 1. J Neurosci. 2013 May 29;33(22):9328-36
All references(50)
Other
accession IDs
MGI:2144078

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory