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Birc2 Gene Detail
Summary
  • Symbol
    Birc2
  • Name
    baculoviral IAP repeat-containing 2
  • Synonyms
    Api1, C330006D17Rik, cIAP1, cIAP-1, HIAP1, IAP1, mcIAP1, MIAP1, MIHB
  • Feature Type
    protein coding gene
  • IDs
    MGI:1197009
    NCBI Gene: 11797
  • Gene Overview
    MyGene.info: BIRC2
  • Alliance
Location & Maps
more
  • Genetic Map
    Chromosome 9, 2.46 cM, cytoband A1
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    BIRC2, baculoviral IAP repeat containing 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    BIRC2, baculoviral IAP repeat containing 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    API1, cIAP1, c-IAP1, Hiap-2, HIAP2, MIHB, RNF48
  • Links
    NCBI Gene ID: 329
    neXtProt AC: NX_Q13490
    UniProt: Q13490

  • Chr Location
    11q22.2; chr11:102347182-102378670 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    21 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice showed a modest reduction in the number of lymphocytes. Mice homozygous for a knock-in allele exhibit increased T cell poliferation and IFNG secretion in response to anti-CD3 stimulation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000047468 VEGA Gene Model | MGI Sequence Detail 18837 C57BL/6J ±  kb
transcript OTTMUST00000122528 VEGA | MGI Sequence Detail 3331 Not Applicable  
polypeptide OTTMUSP00000067186 VEGA | MGI Sequence Detail 612 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    144 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 13
    Genomic 1
    cDNA 12

    Microarray probesets 5
Other
Accession IDs
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MGI:1924866, MGI:2143294
References
more
  • Summaries
    All 87
    Developmental Gene Expression 11
    Gene Ontology 9
    Phenotypes 25
  • Earliest
    J:30406 Rothe M, et al., The TNFR2-TRAF signaling complex contains two novel proteins related to baculoviral inhibitor of apoptosis proteins. Cell. 1995 Dec 29;83(7):1243-52
  • Latest
    J:260804 Annibaldi A, et al., Ubiquitin-Mediated Regulation of RIPK1 Kinase Activity Independent of IKK and MK2. Mol Cell. 2018 Feb 15;69(4):566-580.e5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/09/2018
MGI 6.12
The Jackson Laboratory