Ninj1 MGI Mouse Gene Detail - MGI:1196617

Symbol

Ninj1
Name

ninjurin 1

Feature Type

protein coding gene
IDs

MGI:1196617
NCBI Gene: 18081
Gene Overview

MyGene.info: NINJ1
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr13:49187547-49196251 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 13, 25.14 cM
Mapping Data

3 experiments

SNPs within 2kb

5 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1196617	protein coding gene	Chr13:49187485-49196251 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0020530	protein coding gene	Chr13:48152306-48161065 (+)
A/J	MGP_AJ_G0020484	protein coding gene	Chr13:46440117-46448876 (+)
AKR/J	MGP_AKRJ_G0020461	protein coding gene	Chr13:47753522-47762288 (+)
BALB/cJ	MGP_BALBcJ_G0020480	protein coding gene	Chr13:46654346-46663105 (+)
C3H/HeJ	MGP_C3HHeJ_G0020279	protein coding gene	Chr13:47574587-47583345 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020913	protein coding gene	Chr13:49604853-49613612 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0018498	protein coding gene	Chr13:44419394-44428607 (+)
CAST/EiJ	MGP_CASTEiJ_G0019794	protein coding gene	Chr13:47579894-47594141 (+)
CBA/J	MGP_CBAJ_G0020240	protein coding gene	Chr13:51654078-51662837 (+)
DBA/2J	MGP_DBA2J_G0020362	protein coding gene	Chr13:45965262-45974021 (+)
FVB/NJ	MGP_FVBNJ_G0020341	protein coding gene	Chr13:45483641-45492386 (+)
LP/J	MGP_LPJ_G0020437	protein coding gene	Chr13:48375272-48384031 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0020370	protein coding gene	Chr13:51367339-51376098 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020956	protein coding gene	Chr13:47452949-47461709 (+)
PWK/PhJ	MGP_PWKPhJ_G0019550	protein coding gene	Chr13:46145316-46154047 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0019378	protein coding gene	Chr13:46155035-46164553 (+)
WSB/EiJ	MGP_WSBEiJ_G0019856	protein coding gene	Chr13:47764222-47773111 (+)

Human Ortholog

NINJ1, ninjurin 1

Vertebrate Orthologs

10

Human Ortholog

NINJ1, ninjurin 1
Orthology source: HomoloGene, HGNC
Synonyms

NIN1, NINJURIN
Links

HGNC:7824

NCBI Gene ID: 4814

neXtProt AC: NX_Q92982

UniProt: Q92982
Chr Location

9q22.31; chr9:93121489-93134304 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 88815
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: NINJ1
Gene Tree

Ninj1

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Phenotype Summary

12 phenotypes from 3 alleles in 3 genetic backgrounds
2 images
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Chemically induced (other)

1
Targeted

5
Genomic Mutations

1 involving Ninj1
Incidental Mutations

APF
Find Mice (IMSR)

2 strains or lines available

Homozygotes for a null allele die prematurely exhibiting hydroencephaly and abnormal cellular replicative senescence. Homozygotes for another null allele show resistance to EAE due to reduced leukocyte recruitment into lesion sites, and may display stunted growth, hydroencephaly, and ataxia.

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All GO Annotations

8
GO References

3

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

448
Tissues

50
cDNA Data

81
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ninj1

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Ninj1 interacts with 88 markers (Mir1a-1, Mir1a-2, Mir29a, ...) View All

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All Sequences

57
RefSeq

2
UniProt

5
CCDS

CCDS26497.1
UniGene

18503

Ensembl

ENSMUSG00000037966 (Evidence)
NCBI Gene

18081

			Length	Strain/Species	Flank
genomic	18081	NCBI Gene Model \| MGI Sequence Detail	8705	C57BL/6J	± kb
transcript	NM_013610	RefSeq \| MGI Sequence Detail	1150	C57BL/6
polypeptide	O70131	UniProt \| EBI \| MGI Sequence Detail	152	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000011213 ninjurin-1

(term hierarchy)
InterPro Domains

IPR007007 Ninjurin

IPR015639 Ninjurin1

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All nucleic 82

Genomic 1

cDNA 81

Microarray probesets 4

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MGI:2145366

Summaries

All 37

Developmental Gene Expression 3

Gene Ontology 3

Phenotypes 13
Earliest

J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
Latest

J:268108 Choi S, et al., Ninjurin1 Plays a Crucial Role in Pulmonary Fibrosis by Promoting Interaction between Macrophages and Alveolar Epithelial Cells. Sci Rep. 2018 Dec 3;8(1):17542

TSS for Ninj1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr119678	Chr13:49187485-49187539 (+)	-35 bp
Tssr119679	Chr13:49188156-49188167 (+)	615 bp
Tssr119680	Chr13:49188202-49188216 (+)	662 bp
Tssr119681	Chr13:49188245-49188261 (+)	706 bp
Tssr119683	Chr13:49190329-49190331 (+)	2,783 bp
Tssr119684	Chr13:49190352-49190358 (+)	2,808 bp
Tssr119687	Chr13:49193725-49193760 (+)	6,196 bp
Tssr119688	Chr13:49193861-49193917 (+)	6,342 bp
Tssr119689	Chr13:49195684-49195699 (+)	8,145 bp
Tssr119690	Chr13:49195710-49195738 (+)	8,177 bp
Tssr119691	Chr13:49195928-49195953 (+)	8,394 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 10/15/2019 MGI 6.14