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Ninj1 Gene Detail
Summary
  • Symbol
    Ninj1
  • Name
    ninjurin 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196617
    NCBI Gene: 18081
  • Gene Overview
    MyGene.info: NINJ1
Location & Maps
more
  • Sequence Map
    Chr13:49187485-49196244 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8760 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 25.14 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    NINJ1, ninjurin 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NINJ1, ninjurin 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NIN1, NINJURIN
  • Links
    NCBI Gene ID: 4814
    neXtProt AC: NX_Q92982

  • Chr Location
    9q22.31; chr9:93121489-93134304 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 88815
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NINJ1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 3 alleles in 3 genetic backgrounds
    2 images
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving Ninj1
  • Incidental Mutations
    APF
Homozygotes for a null allele die prematurely exhibiting hydroencephaly and abnormal cellular replicative senescence. Homozygotes for another null allele show resistance to EAE due to reduced leukocyte recruitment into lesion sites, and may display stunted growth, hydroencephaly, and ataxia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027739 VEGA Gene Model | MGI Sequence Detail 8760 C57BL/6J ±  kb
transcript OTTMUST00000068648 VEGA | MGI Sequence Detail 1321 Not Applicable  
polypeptide OTTMUSP00000034752 VEGA | MGI Sequence Detail 210 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    5 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 80
    Genomic 1
    cDNA 79

    Microarray probesets 4
Other
Accession IDs
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MGI:2145366
References
more
  • Summaries
    All 30
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:45697 Chadwick BP, et al., The human homologue of the ninjurin gene maps to the candidate region of hereditary sensory neuropathy type I (HSNI). Genomics. 1998 Jan 1;47(1):58-63
  • Latest
    J:233984 Kirov JV, et al., Reporter Gene Silencing in Targeted Mouse Mutants Is Associated with Promoter CpG Island Methylation. PLoS One. 2015;10(8):e0134155

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory