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Cbx7
Gene Detail
 Symbol
Name
ID
Cbx7
chromobox 7
MGI:1196439
Synonyms 1600014J01Rik, D15Ertd417e
Feature Type protein coding gene
Genetic Map
Chromosome 15
37.85 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr15:79915807-79971119 bp, - strand
From VEGA annotation of GRCm38

  55313 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:65296  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Cbx7

Human
homologs
Human Homolog CBX7, chromobox homolog 7
NCBI Gene ID 23492
neXtProt AC  NX_O95931
Human Chr (Location)  22q13.1; chr22:39130772-39152656 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(377) : Gene trapped(373) Radiation induced(1) Targeted(3)
Genomic Mutations involving Cbx7 (1)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit increased body length and develop liver and lung adenomas and carcinomas while mutant embryonic fibriblasts show a higher growth rate and reduced susceptibility to senescence.
 
Phenotype Images(2)
Interactions
Cbx7 interacts with 260 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process chromatin modification, negative regulation of transcription from RNA polymerase II promoter, ...
Component cytoplasm, heterochromatin, ...
Function chromatin binding, methylated histone binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (15)    Tissues (15)    Images (10)
Theiler Stages: 21, 26, 28
Assay TypeResults
RNA in situ 15
cDNA source data(55)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(57) Genomic(1) cDNA(55) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000017275 (Evidence)
Ensembl Gene ModelENSMUSG00000053411 (Evidence)
Entrez Gene52609 (Evidence)
UniGene323442
DFCITC1578246, TC1597407, TC1652023
NIA Mouse Gene IndexU036418
PDB2KVM
Consensus CDS ProjectCCDS37143.1
International Mouse Knockout Project StatusCbx7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017275 VEGA Gene Model | MGI Sequence Detail 55313 C57BL/6J ±  kb
transcript OTTMUST00000041848 VEGA | MGI Sequence Detail 3388 Not Applicable 
polypeptide OTTMUSP00000018818 VEGA | MGI Sequence Detail 251 Not Applicable 

For the selected sequences
All sequences(79) RefSeq(17) UniProt(6)
Polymorphisms SNPs within 2kb(969 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023780 Chromo domain
InterPro IPR023779 Chromo domain, conserved site
InterPro IPR016197 Chromo domain-like
InterPro IPR000953 Chromo domain/shadow
InterPro IPR017984 Chromo domain subgroup
Protein Ontology PR:000005088 chromobox protein homolog 7
References (Earliest) J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
(Latest) J:207230 Wu HA, et al., Mitogen-activated protein kinase signaling mediates phosphorylation of polycomb ortholog Cbx7. J Biol Chem. 2013 Dec 20;288(51):36398-408
All references(50)
Other
accession IDs
MGI:1917043, MGI:2146090

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory