Tnfaip3 MGI Mouse Gene Detail - MGI:1196377 - tumor necrosis factor, alpha-induced protein 3

Tnfaip3 Gene Detail

Symbol

Tnfaip3
Name

tumor necrosis factor, alpha-induced protein 3
Synonyms

A20, Tnfip3, zinc finger protein A20

Feature Type

protein coding gene
IDs

MGI:1196377
NCBI Gene: 21929
Gene Overview

MyGene.info: TNFAIP3

Sequence Map

Chr10:19000910-19015657 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

14748 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 8.08 cM
Mapping Data

3 experiments

Human Ortholog

TNFAIP3, TNF alpha induced protein 3

Vertebrate Orthologs

9

Human Ortholog

TNFAIP3, TNF alpha induced protein 3
Orthology source: HomoloGene, HGNC
Synonyms

A20, AISBL, OTUD7C, TNFA1P2
Links

HGNC:11896

NCBI Gene ID: 7128

neXtProt AC: NX_P21580
Chr Location

6q23; chr6:137866317-137883314 (+) GRCh38.p2

HomoloGene

Vertebrate Homology Class 4582
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish
HCOP

human homology predictions: TNFAIP3
Protein SuperFamily

tumor necrosis factor alpha-induced protein 3
Gene Tree

Tnfaip3

Diseases

1 with human TNFAIP3 associations

				Human Disease	Mouse Models
				Autoinflammatory Syndrome, Familial, Behcet-Like; AISBL OMIM: 616744

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

85 phenotypes from 8 alleles in 9 genetic backgrounds
8 phenotypes from multigenic genotypes
2 images
33 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Chemically induced (other)

1
Targeted

12
Genomic Mutations

1 involving Tnfaip3
Incidental Mutations

Mutagenetix , APF , CvDC

Homozygous null mice display runting, severe multi-organ inflammation, hypersensitivity to lipopolysaccharide and TNF, and premature death. Older mice homozygous for point mutations that disrupt deubiquitinating activity develop splenomegaly and show an increased number of myeloid cells.

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All GO Annotations

95
GO References

24

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

35
Tissues

21
cDNA Data

98
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO
Other Vertebrate Links

ZFIN tnfaip3

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Tnfaip3 interacts with 280 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

49
RefSeq

6
UniProt

8
CCDS

CCDS23715.1
UniGene

116683

			Length	Strain/Species	Flank
genomic	OTTMUSG00000018149	VEGA Gene Model \| MGI Sequence Detail	14748	C57BL/6J	± kb
transcript	OTTMUST00000043847	VEGA \| MGI Sequence Detail	4422	Not Applicable
polypeptide	OTTMUSP00000019689	VEGA \| MGI Sequence Detail	775	Not Applicable

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SNPs within 2kb

104 from dbSNP Build 142

RFLP

1

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UniProt

8 Sequences
Protein Ontology

PR:000016474 tumor necrosis factor alpha-induced protein 3
PDB

5DQ6
EC

3.4.19.12, 6.3.2.-
InterPro Domains

IPR033478 A20 peptidase

IPR003323 OTU domain

IPR002653 Zinc finger, A20-type

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All nucleic 99

cDNA 99

Microarray probesets 4

Summaries

All 86

Developmental Gene Expression 7

Gene Ontology 24

Phenotypes 33
Earliest

J:43379 Tewari M, et al., Lymphoid expression and regulation of A20, an inhibitor of programmed cell death. J Immunol. 1995 Feb 15;154(4):1699-706
Latest

J:232833 Onizawa M, et al., The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis. Nat Immunol. 2015 Jun;16(6):618-27

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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