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Tnfaip3 Gene Detail
Summary
  • Symbol
    Tnfaip3
  • Name
    tumor necrosis factor, alpha-induced protein 3
  • Synonyms
    A20, Tnfip3, zinc finger protein A20
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196377
    NCBI Gene: 21929
  • Gene Overview
    MyGene.info: TNFAIP3
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr10:19000910-19015657 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      14748 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 8.08 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    TNFAIP3, TNF alpha induced protein 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TNFAIP3, TNF alpha induced protein 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    A20, AISBL, OTUD7C, TNFA1P2
  • Links
    NCBI Gene ID: 7128
    neXtProt AC: NX_P21580
    UniProt: P21580

  • Chr Location
    6q23.3; chr6:137866317-137883314 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    85 phenotypes from 8 alleles in 9 genetic backgrounds
    8 phenotypes from multigenic genotypes
    2 images
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display runting, severe multi-organ inflammation, hypersensitivity to lipopolysaccharide and TNF, and premature death. Older mice homozygous for point mutations that disrupt deubiquitinating activity develop splenomegaly and show an increased number of myeloid cells.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    88
  • GO References
    25
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    35
  • Tissues
    21
  • cDNA Data
    98
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000018149 VEGA Gene Model | MGI Sequence Detail 14748 C57BL/6J ±  kb
    transcript OTTMUST00000044001 VEGA | MGI Sequence Detail 4334 Not Applicable  
    polypeptide OTTMUSP00000019755 VEGA | MGI Sequence Detail 775 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      104 from dbSNP Build 142
    • RFLP
      1
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 99
      cDNA 99

      Microarray probesets 4
    References
    more
    • Summaries
      All 119
      Developmental Gene Expression 8
      Gene Ontology 25
      Phenotypes 42
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:257957 Sokhi UK, et al., Dissection and function of autoimmunity-associated TNFAIP3 (A20) gene enhancers in humanized mouse models. Nat Commun. 2018 Feb 13;9(1):658
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    05/15/2018
    MGI 6.12     		The Jackson Laboratory