Angel2 MGI Mouse Gene Detail - MGI:1196310

Symbol

Angel2
Name

angel homolog 2
Synonyms

2610307I21Rik, 5730410O10Rik, D1Ertd396e, D1Ertd654e

Feature Type

protein coding gene
IDs

MGI:1196310
NCBI Gene: 52477
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr1:190657309-190679159 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 96.28 cM
Mapping Data

4 experiments

SNPs within 2kb

110 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1196310	protein coding gene	Chr1:190657305-190679160 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016933	protein coding gene	Chr1:197935050-197957404 (+)
A/J	MGP_AJ_G0016912	protein coding gene	Chr1:189828108-189849944 (+)
AKR/J	MGP_AKRJ_G0016877	protein coding gene	Chr1:195439202-195461030 (+)
BALB/cJ	MGP_BALBcJ_G0016870	protein coding gene	Chr1:190504055-190525879 (+)
C3H/HeJ	MGP_C3HHeJ_G0016694	protein coding gene	Chr1:196295475-196318059 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017333	protein coding gene	Chr1:204244543-204266879 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015040	protein coding gene	Chr1:180734183-180755796 (+)
CAST/EiJ	MGP_CASTEiJ_G0016277	protein coding gene	Chr1:195885087-195907495 (+)
CBA/J	MGP_CBAJ_G0016668	protein coding gene	Chr1:211806016-211830411 (+)
DBA/2J	MGP_DBA2J_G0016774	protein coding gene	Chr1:188551251-188573204 (+)
FVB/NJ	MGP_FVBNJ_G0016770	protein coding gene	Chr1:186676518-186698589 (+)
LP/J	MGP_LPJ_G0016849	protein coding gene	Chr1:199110765-199133074 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016802	protein coding gene	Chr1:218523574-218546411 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017370	protein coding gene	Chr1:195328177-195353646 (+)
PWK/PhJ	MGP_PWKPhJ_G0016064	protein coding gene	Chr1:187827175-187849479 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015840	protein coding gene	Chr1:194317079-194339762 (+)
WSB/EiJ	MGP_WSBEiJ_G0016339	protein coding gene	Chr1:195549875-195571601 (+)

Human Ortholog

ANGEL2, angel homolog 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ANGEL2, angel homolog 2
Synonyms

Ccr4d, KIAA0759L
Links

HGNC:30534

NCBI Gene ID: 90806

neXtProt AC: NX_Q5VTE6

UniProt: Q5VTE6
Chr Location

1q32.3; chr1:212992182-213015867 (-) GRCh38

MGI Vertebrate Homology

Angel2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ANGEL2
Gene Tree

Angel2

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
9 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

13
Endonuclease-mediated

3
Gene trapped

7
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available

Mice homozygous for a knock-out allele are viable and overtly normal but show a mild alteration of de novo translation in heart and liver mitochondria. Mitochondrial transcripts that undergo non-canonical RNA processing accumulate 3' phosphates, preventing their polyadenylation, causing a respiratory chain deficiency.

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All GO Annotations

11
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

148
Literature Summary

1

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA ANGEL2

Xenbase angel2

ZFIN angel2

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All Sequences

118
RefSeq

34
UniProt

3
CCDS

CCDS15612.1, CCDS56667.1

Ensembl

ENSMUSG00000026634 (Evidence)
NCBI Gene

52477

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026634	Ensembl Gene Model \| MGI Sequence Detail	21851	C57BL/6J	± kb
transcript	ENSMUST00000066632	Ensembl \| MGI Sequence Detail	3714	Not Applicable
polypeptide	ENSMUSP00000064556	Ensembl \| MGI Sequence Detail	544	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000004022 protein angel homolog 2

(term hierarchy)
InterPro Domains

IPR005135 Endonuclease/exonuclease/phosphatase

IPR036691 Endonuclease/exonuclease/phosphatase superfamily

IPR045816 Protein angel homolog 2, N-terminal

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All nucleic 152

cDNA 150

Primer pair 2

Microarray probesets 10

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MGI:1277170, MGI:1917712, MGI:1917755, MGI:2138341

Summaries

All 38

Developmental Gene Expression 1

Gene Ontology 3

Phenotypes 9
Earliest

J:51600 Fowler KJ, et al., Mouse centromere protein F (Cenpf) gene maps to the distal region of chromosome 1 by interspecific backcross analysis. Cytogenet Cell Genet. 1998;82(3-4):180-1
Latest

J:332461 Clemente P, et al., ANGEL2 phosphatase activity is required for non-canonical mitochondrial RNA processing. Nat Commun. 2022 Sep 30;13(1):5750

TSS for Angel2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr10715	Chr1:190660698-190660747 (+)	3,414 bp
Tssr10716	Chr1:190660770-190660849 (+)	3,501 bp
Tssr10717	Chr1:190661026-190661085 (+)	3,747 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23