About   Help   FAQ
Pla2g4a
Gene Detail
Symbol

Name
ID
Pla2g4a
phospholipase A2, group IVA (cytosolic, calcium-dependent)
MGI:1195256
Synonyms
cPLA2, cPLA2alpha, cytosolic phospholipase A2, cytosolic PLA2, Pla2g4, Type IV PLA2
Feature Type
protein coding gene
Genetic Map
Chromosome 1
63.51 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:149829618-149961290 bp, - strand
From VEGA annotation of GRCm38

  131673 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32059  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: PLA2G4A
Protein SuperFamily: cytosolic phospholipase A2
Gene Tree: Pla2g4a

Human
homologs
PLA2G4A, phospholipase A2, group IVA (cytosolic, calcium-dependent)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5321
neXtProt AC: NX_P47712

Human Synonyms: cPLA2, cPLA2-alpha, PLA2G4

Human Chr (Location): 1q25; chr1:186828900-186988981 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PLA2G4A

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(2) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygouse for disruptions in this gene display reduced allergic and autoimmune reactions. They also display an increased incidence of insulin and reduced female reproductive performance.
 
Interactions
Pla2g4a interacts with 133 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (308)    Tissues (159)    Images (36)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 306
RT-PCR 2
cDNA source data(43)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA PLA2G4A ; Xenbase pla2g4a ; ZFIN pla2g4aa    NEW 
Molecular
reagents
All nucleic(46) Genomic(2) cDNA(43) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000016429 (Evidence)
Ensembl Gene Model ENSMUSG00000056220 (Evidence)
Entrez Gene 18783 (Evidence)
UniGene 4186
DFCI TC1579217
DoTS DT.101309358, DT.528053, DT.87028061
NIA Mouse Gene Index U021869
EC 3.1.1.4, 3.1.1.5
Consensus CDS Project CCDS15352.1
International Mouse Phenotyping Consortium Status Pla2g4a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016429 VEGA Gene Model | MGI Sequence Detail 131673 C57BL/6J ±  kb
transcript OTTMUST00000039570 VEGA | MGI Sequence Detail 2856 Not Applicable 
polypeptide OTTMUSP00000017675 VEGA | MGI Sequence Detail 748 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(4) UniProt(4)
Polymorphisms
SNPs within 2kb(2406 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR002642 Lysophospholipase, catalytic domain
Protein Ontology PR:000012804 cytosolic phospholipase A2
References
(Earliest) J:28587 Clark MA, et al., Cloning of a phospholipase A2-activating protein. Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5418-22
(Latest) J:216406 Norris PC, et al., Phospholipase A2 regulates eicosanoid class switching during inflammasome activation. Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12746-51
All references(120)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/18/2015
MGI 6.0
The Jackson Laboratory