Pla2g4a
Gene Detail

Symbol Name ID

Pla2g4a phospholipase A2, group IVA (cytosolic, calcium-dependent) MGI:1195256

Synonyms

cPLA2, cPLA2alpha, cytosolic phospholipase A2, cytosolic PLA2, Pla2g4, Type IV PLA2

Feature Type

protein coding gene

Genetic Map

Chromosome 1

63.51 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr1:149829618-149961290 bp, - strand From VEGA annotation of GRCm38   131673 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:32059  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: cytosolic phospholipase A2
Gene Tree: Pla2g4a

Human homologs

Human Homolog		PLA2G4A, phospholipase A2, group IVA (cytosolic, calcium-dependent)
NCBI Gene ID		5321
neXtProt AC		NX_P47712
Human Synonyms		cPLA2-alpha, PLA2G4
Human Chr (Location)		1q25; chr1:186798032-186958113 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PLA2G4A

Alleles and phenotypes

All alleles(4) : Targeted(2) Gene trapped(2)
 

Mice homozygouse for disruptions in this gene display reduced allergic and autoimmune reactions. They also display an increased incidence of insulin and reduced female reproductive performance.

 

Gene Ontology (GO) classifications

All GO classifications: (40 annotations)

Process	arachidonic acid metabolic process, arachidonic acid secretion, ...
Component	cytoplasm, cytoplasmic vesicle, ...
Function	calcium-dependent phospholipase A2 activity, calcium-dependent phospholipid binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (264)    Tissues (115)    Images (34)
Theiler Stages: 22, 23, 26

Assay Type	Results
RNA in situ	262
RT-PCR	2

cDNA source data(43)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(46) Genomic(2) cDNA(43) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000016429 (Evidence)
Ensembl Gene Model	ENSMUSG00000056220 (Evidence)
Entrez Gene	18783 (Evidence)
UniGene	4186
DFCI	TC1579217
DoTS	DT.101309358, DT.528053, DT.87028061
NIA Mouse Gene Index	U021869
EC	3.1.1.4, 3.1.1.5
Consensus CDS Project	CCDS15352.1
International Mouse Knockout Project Status	Pla2g4a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016429	VEGA Gene Model | MGI Sequence Detail	131673	C57BL/6J
transcript	OTTMUST00000039570	VEGA | MGI Sequence Detail	2856	Not Applicable
polypeptide	OTTMUSP00000017675	VEGA | MGI Sequence Detail	748	Not Applicable

All sequences(34) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(1538 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016035	Acyl transferase/acyl hydrolase/lysophospholipase
InterPro	IPR000008	C2 calcium-dependent membrane targeting
InterPro	IPR008973	C2 calcium/lipid-binding domain, CaLB
InterPro	IPR018029	C2 membrane targeting protein
InterPro	IPR002642	Lysophospholipase, catalytic domain
Protein Ontology	PR:000012804	cytosolic phospholipase A2

References

(Earliest) J:28587 Clark MA, et al., Cloning of a phospholipase A2-activating protein. Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5418-22
(Latest) J:191686 Wang DJ, et al., Cytosolic phospholipase A2 alpha/arachidonic acid signaling mediates depolarization-induced suppression of excitation in the cerebellum. PLoS One. 2012;7(8):e41499
All references(115)