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Pla2g4a Gene Detail
Summary
  • Symbol
    Pla2g4a
  • Name
    phospholipase A2, group IVA (cytosolic, calcium-dependent)
  • Synonyms
    cPLA2, cPLA2alpha, cytosolic phospholipase A2, cytosolic PLA2, Pla2g4, Type IV PLA2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1195256
    NCBI Gene: 18783
  • Alliance
    genome feature page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:149705369-149837041 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 63.51 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4713 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1195256
 protein coding gene Chr1:149705369-149837041 (-)
129S1/SvImJ ENSMUSG00200002650
 protein coding gene Chr1:147144374-147282517 (-)
A/J ENSMUSG00195012917
 protein coding gene Chr1:146504933-146642655 (-)
AKR/J ENSMUSG00220004944
 protein coding gene Chr1:146261960-146400111 (-)
BALB/cJ ENSMUSG00180031140
 protein coding gene Chr1:146722309-146854023 (-)
C3H/HeJ ENSMUSG00175002850
 protein coding gene Chr1:146756781-146894493 (-)
C57BL/6NJ ENSMUSG00215003612
 protein coding gene Chr1:146661444-146793132 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014684
 protein coding gene Chr1:140547877-140678109 (-)
CAST/EiJ ENSTCUG00005005312
 protein coding gene Chr1:145273470-145410171 (-)
CBA/J ENSMUSG00210030428
 protein coding gene Chr1:146653845-146791513 (-)
DBA/2J ENSMUSG00185006942
 protein coding gene Chr1:150932324-151070141 (-)
FVB/NJ ENSMUSG00205019558
 protein coding gene Chr1:145804506-145941965 (-)
JF1/MsJ ENSUMUG00000011809
 protein coding gene Chr1:150055411-150187747 (-)
LP/J ENSMUSG00230000286
 protein coding gene Chr1:150451853-150589984 (-)
NOD/ShiLtJ ENSMUSG00190011772
 protein coding gene Chr1:146509818-146641627 (-)
NZO/HlLtJ ENSMUSG00225004628
 protein coding gene Chr1:154202921-154341047 (-)
PWK/PhJ ENSLUMG00010027593
 protein coding gene Chr1:145417666-145548875 (-)
SPRET/EiJ ENSMSPG00010005185
 protein coding gene Chr1:148494100-148642056 (-)
WSB/EiJ ENSIUOG00005023529
 protein coding gene Chr1:146066452-146204621 (-)



Homology
more
  • Human Ortholog
    PLA2G4A, phospholipase A2 group IVA
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLA2G4A, phospholipase A2 group IVA
  • Synonyms
    cPLA2, cPLA2-alpha, GURDP, PLA2G4
  • Links
    NCBI Gene ID: 5321
    UniProt: P47712

  • Chr Location
    1q31.1; chr1:186828949-186988986 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    41 phenotypes from 2 alleles in 7 genetic backgrounds
    5 phenotypes from multigenic genotypes
    109 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygouse for disruptions in this gene display reduced allergic and autoimmune reactions. They also display an increased incidence of insulin and reduced female reproductive performance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    111
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    914
  • Tissues
    168
  • cDNA Data
    44
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18783 NCBI Gene Model | MGI Sequence Detail 131673 C57BL/6J ±  kb
    transcript NM_008869 RefSeq | MGI Sequence Detail 2869 ZRU/MplStud  
    polypeptide P47713 UniProt | EBI | MGI Sequence Detail 748 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 48
      Genomic 2
      cDNA 44
      Primer pair 1
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 189
      Developmental Gene Expression 6
      Gene Ontology 19
      Phenotypes 109
    • Earliest
      J:28587 Clark MA, et al., Cloning of a phospholipase A2-activating protein. Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5418-22
    • Latest
      J:385934 Luo H, et al., Membrane-associated estrogen receptor alpha prevents the amyloid beta-induced suppression of GIRK channel activity in hippocampal neurons from female mice. Biol Sex Differ. 2025 Nov 6;16(1):90
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory