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Pla2g4a
Gene Detail
 Symbol
Name
ID
Pla2g4a
phospholipase A2, group IVA (cytosolic, calcium-dependent)
MGI:1195256
Synonyms cPLA2, cPLA2alpha, cytosolic phospholipase A2, cytosolic PLA2, Pla2g4, Type IV PLA2
Feature Type protein coding gene
Genetic Map
Chromosome 1
63.51 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:149829618-149961290 bp, - strand
From VEGA annotation of GRCm38

  131673 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32059  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: cytosolic phospholipase A2
Gene Tree: Pla2g4a

Human
homologs
Human Homolog PLA2G4A, phospholipase A2, group IVA (cytosolic, calcium-dependent)
NCBI Gene ID 5321
neXtProt AC  NX_P47712
Human Synonyms  cPLA2-alpha, PLA2G4
Human Chr (Location)  1q25; chr1:186828900-186988981 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PLA2G4A
Alleles
and
phenotypes
All alleles(4) : Targeted(2) Gene trapped(2)
 
Mice homozygouse for disruptions in this gene display reduced allergic and autoimmune reactions. They also display an increased incidence of insulin and reduced female reproductive performance.
 
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process arachidonic acid metabolic process, arachidonic acid secretion, ...
Component cytoplasm, cytoplasmic vesicle, ...
Function calcium-dependent phospholipase A2 activity, calcium-dependent phospholipid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (308)    Tissues (159)    Images (36)
Theiler Stages: 22, 23, 26, 28
Assay TypeResults
RNA in situ 306
RT-PCR 2
cDNA source data(43)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(46) Genomic(2) cDNA(43) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016429 (Evidence)
Ensembl Gene ModelENSMUSG00000056220 (Evidence)
Entrez Gene18783 (Evidence)
UniGene4186
DFCITC1579217
DoTSDT.101309358, DT.528053, DT.87028061
NIA Mouse Gene IndexU021869
EC3.1.1.4, 3.1.1.5
Consensus CDS ProjectCCDS15352.1
International Mouse Knockout Project StatusPla2g4a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016429 VEGA Gene Model | MGI Sequence Detail 131673 C57BL/6J ±  kb
transcript OTTMUST00000039570 VEGA | MGI Sequence Detail 2856 Not Applicable 
polypeptide OTTMUSP00000017675 VEGA | MGI Sequence Detail 748 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(2406 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase
InterPro IPR000008 C2 calcium-dependent membrane targeting
InterPro IPR002642 Lysophospholipase, catalytic domain
Protein Ontology PR:000012804 cytosolic phospholipase A2
References (Earliest) J:28587 Clark MA, et al., Cloning of a phospholipase A2-activating protein. Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5418-22
(Latest) J:204931 Suram S, et al., Cytosolic phospholipase A(2)alpha and eicosanoids regulate expression of genes in macrophages involved in host defense and inflammation. PLoS One. 2013;8(7):e69002
All references(118)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory