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Tnfrsf9
Gene Detail
Symbol

Name
ID
Tnfrsf9
tumor necrosis factor receptor superfamily, member 9
MGI:1101059
Synonyms
4-1BB, A930040I11Rik, Cd137, CDw137, ILA, Ly63
Feature Type
protein coding gene
Genetic Map
Chromosome 4
81.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)
Sequence Map
Chr4:150914562-150946102 bp, + strand
From VEGA annotation of GRCm38

  31541 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : Endonuclease-mediated(2) Gene trapped(12) Targeted(8)
Genomic Mutations involving Tnfrsf9 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in enhanced T cell proliferation, decreased B cell IgG production, decreased cytotoxic T cell activity, and increased numbers of erythrocytes, granulocyte macrophages, and multipotential progenitor cells in the bone marrow, blood, and spleen.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Tnfrsf9 interacts with 173 markers (Mir18, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (1 records)
Data Summary: Results (24)    Tissues (15)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
cDNA source data(47)
External Resources: Allen Institute   Expression Atlas
Molecular
reagents
All nucleic(52) Genomic(1) cDNA(51)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000010241 (Evidence)
Ensembl Gene ModelENSMUSG00000028965 (Evidence)
Entrez Gene102631764, 21942
UniGene244187
DFCITC1605267, TC1587986, TC1638769
DoTSDT.101128459, DT.91326940, DT.101391848, DT.490248, DT.101367730
NIA Mouse Gene IndexU005145, U005143
PDB1D0J
Consensus CDS ProjectCCDS18976.1, CCDS38980.1
International Mouse Knockout Project StatusTnfrsf9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010241 VEGA Gene Model | MGI Sequence Detail 31541 C57BL/6J ±  kb
transcript OTTMUST00000023800 VEGA | MGI Sequence Detail 2099 Not Applicable 
polypeptide OTTMUSP00000010903 VEGA | MGI Sequence Detail 256 Not Applicable 

For the selected sequences
All sequences(65) UniProt(11)
Polymorphisms
RFLP(2) : SNPs within 2kb(224 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001368 TNFR/NGFR cysteine-rich region
InterPro IPR020413 Tumour necrosis factor receptor 9
Protein Ontology PR:000001965 tumor necrosis factor receptor superfamily member 9
References
(Earliest) J:14661 Kwon BS, et al., cDNA sequences of two inducible T-cell genes. Proc Natl Acad Sci U S A. 1989 Mar;86(6):1963-7
(Latest) J:208927 Chen YG, et al., Gene targeting in NOD mouse embryos using zinc-finger nucleases. Diabetes. 2014 Jan;63(1):68-74
All references(131)
Other
accession IDs
MGI:1925690, MGI:2140130, MGI:2140239

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory