Tnfrsf9
Gene Detail

Symbol Name ID

Tnfrsf9 tumor necrosis factor receptor superfamily, member 9 MGI:1101059

Synonyms

4-1BB, A930040I11Rik, Cd137, CDw137, ILA, Ly63

Feature Type

protein coding gene

Genetic Map

Chromosome 4

81.52 cM
Detailed Genetic Map ± 1 cM


Mapping data(11)

Sequence Map

Chr4:150914562-150946102 bp, + strand From VEGA annotation of GRCm38   31541 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1199  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: tumor necrosis factor receptor superfamily member 9
Gene Tree: Tnfrsf9

Human homologs

Human Homolog		TNFRSF9, tumor necrosis factor receptor superfamily, member 9
NCBI Gene ID		3604
neXtProt AC		NX_Q07011
Human Synonyms		4-1BB, CD137, CDw137, ILA
Human Chr (Location)		1p36; chr1:7975931-8003225 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(16) : Targeted(4) Gene trapped(12)
 

Homozygous mutation of this gene results in enhanced T cell proliferation, decreased B cell IgG production, decreased cytotoxic T cell activity, and increased numbers of erythrocytes, granulocyte macrophages, and multipotential progenitor cells in the bone marrow, blood, and spleen.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	negative regulation of interleukin-10 secretion, negative regulation of interleukin-12 secretion, ...
Component	external side of plasma membrane, extracellular space, ...
Function	cytokine binding, receptor activity

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (24)    Tissues (15)    Images (2)
Theiler Stages: 23

Assay Type	Results
RNA in situ	24

cDNA source data(47)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(52) Genomic(1) cDNA(51)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000010241 (Evidence)
Ensembl Gene Model	ENSMUSG00000028965 (Evidence)
Entrez Gene	21942 (Evidence)
UniGene	244187
DFCI	TC1581579, TC1587986, TC1605267, TC1638769, TC1702747
DoTS	DT.101128459, DT.101367730, DT.101391848, DT.490248, DT.91326940, DT.94346706
NIA Mouse Gene Index	U005143, U005145
PDB	1D0J
Consensus CDS Project	CCDS18976.1, CCDS38980.1
International Mouse Knockout Project Status	Tnfrsf9

Sequences

Length	Strain/Species
genomic	OTTMUSG00000010241	VEGA Gene Model | MGI Sequence Detail	31541	C57BL/6J
transcript	OTTMUST00000023800	VEGA | MGI Sequence Detail	2099	Not Applicable
polypeptide	OTTMUSP00000010903	VEGA | MGI Sequence Detail	256	Not Applicable

All sequences(75) RefSeq(6) UniProt(6)

Polymorphisms

RFLP(2) : SNPs(101 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001368	TNFR/NGFR cysteine-rich region
InterPro	IPR020413	Tumour necrosis factor receptor 9
Protein Ontology	PR:000001965	tumor necrosis factor receptor superfamily member 9

References

(Earliest) J:14661 Kwon BS, et al., cDNA sequences of two inducible T-cell genes. Proc Natl Acad Sci U S A. 1989 Mar;86(6):1963-7
(Latest) J:195515 Lin GH, et al., GITR-Dependent Regulation of 4-1BB Expression: Implications for T Cell Memory and Anti-4-1BB-Induced Pathology. J Immunol. 2013 May 1;190(9):4627-39
All references(120)

Other accession IDs

MGI:1925690, MGI:2140130, MGI:2140239