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Krt6a
Gene Detail
Symbol

Name
ID
Member of
Krt6a
keratin 6A
MGI:1100845
Krt6 cluster
Synonyms
Krt2-6a, Krt2-6c, mK6[a], MK6a
Feature Type
protein coding gene
Genetic Map
Chromosome 15
56.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr15:101689932-101694307 bp, - strand
From Ensembl annotation of GRCm38

  4376 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:136794  Vertebrate Homology Class
1 human; 2 mouse; 1 chimpanzee

HCOP human homology predictions: KRT6B
Gene Tree: Krt6a

Human
homologs
KRT6B, keratin 6B, type II
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3854
neXtProt AC: NX_P04259

Human Synonyms: CK6B, CK-6B, K6B, KRTL1, PC2, PC4

Human Chr (Location): 12q13.13; chr12:52446651-52452126 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human KRT6B

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Radiation induced(1) Targeted(4)
Genomic Mutations involving Krt6a (2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a targeted null mutation exhibit delayed wound healing.
 
Mutations Annotated to Human Diseases (1)    Phenotype Images(5)
Interactions
Krt6a interacts with 90 markers (Mir15a, Mir23a, Mir23b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process intermediate filament organization, keratinization, ...
Component extracellular exosome, intermediate filament, ...
Function structural molecule activity
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (177)    Tissues (65)    Images (34)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 10
RNA in situ 146
RT-PCR 21
cDNA source data(32)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100490652    NEW 
Molecular
reagents
All nucleic(45) Genomic(9) cDNA(32) Primer pair(4)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000058354 (Evidence)
Entrez Gene 16687 (Evidence)
UniGene 302399
DFCI TC1581306
NIA Mouse Gene Index U052499
Consensus CDS Project CCDS27860.1
International Mouse Phenotyping Consortium Status Krt6a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000058354 Ensembl Gene Model | MGI Sequence Detail 4376 C57BL/6J ±  kb
transcript ENSMUST00000023788 Ensembl | MGI Sequence Detail 2256 Not Applicable 
polypeptide ENSMUSP00000023788 Ensembl | MGI Sequence Detail 553 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(35 from dbSNP Build 137)    SNPs within 2kb including multiple locations(49)
Protein-related
information
ResourceIDDescription
InterPro IPR001664 Intermediate filament protein
InterPro IPR018039 Intermediate filament protein, conserved site
InterPro IPR003054 Type II keratin
Protein Ontology PR:000009482 keratin, type II cytoskeletal 6A
References
(Earliest) J:43414 Steinert PM, et al., The complete cDNA and deduced amino acid sequence of a type II mouse epidermal keratin of 60,000 Da: analysis of sequence differences between type I and type II keratins. Proc Natl Acad Sci U S A. 1984 Sep;81(18):5709-13
(Latest) J:216310 Jin JZ, et al., Deciphering TGF-beta3 function in medial edge epithelium specification and fusion during mouse secondary palate development. Dev Dyn. 2014 Dec;243(12):1536-43
All references(52)
Other
accession IDs
MGI:1333767, MGI:1913622

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory