Krt6a
Gene Detail

Symbol Name ID

Krt6a keratin 6A MGI:1100845

Synonyms

Krt2-6a, Krt2-6c, mK6[a], MK6a

Feature Type

protein coding gene

Genetic Map

Chromosome 15

56.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr15:101689932-101694307 bp, - strand From Ensembl annotation of GRCm38   4376 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:36182  Vertebrate Homology Class
1 human; 2 mouse; 1 chimpanzee; 1 rhesus macaque; 3 cattle; 2 dog

Gene Tree: Krt6a

Human homologs

Human Homolog		KRT6A, keratin 6A
NCBI Gene ID		3853
neXtProt AC		NX_P02538
Human Synonyms		CK6A, CK6C, CK6D, K6A, K6C, K6D, KRT6C, KRT6D
Human Chr (Location)		12q13.13; chr12:52880958-52887181 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human KRT6A

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for a targeted null mutation exhibit delayed wound healing.

 
Alleles Annotated to Human Diseases(1)    Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	intermediate filament organization, keratinization, ...
Component	intermediate filament, keratin filament
Function	structural molecule activity

External Resources: FuncBase

Expression

Literature Summary: (16 records)
Data Summary: Results (173)    Tissues (63)    Images (32)
Theiler Stages: 20, 21, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	10
RNA in situ	142
RT-PCR	21

cDNA source data(32)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(45) Genomic(9) cDNA(32) Primer pair(4)
Microarray probesets(6)

Other database links

Ensembl Gene Model	ENSMUSG00000058354 (Evidence)
Entrez Gene	16687 (Evidence)
UniGene	302399
DFCI	TC1581306
NIA Mouse Gene Index	U052499
Consensus CDS Project	CCDS27860.1
International Mouse Knockout Project Status	Krt6a

Sequences

Length	Strain/Species
genomic	ENSMUSG00000058354	Ensembl Gene Model | MGI Sequence Detail	4376	C57BL/6J
transcript	ENSMUST00000023788	Ensembl | MGI Sequence Detail	2256	Not Applicable
polypeptide	ENSMUSP00000023788	Ensembl | MGI Sequence Detail	553	Not Applicable

All sequences(16) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(22 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR016044	Filament
InterPro	IPR001664	Intermediate filament protein
InterPro	IPR018039	Intermediate filament protein, conserved site
InterPro	IPR003054	Type II keratin
Protein Ontology	PR:000009482	keratin, type II cytoskeletal 6A

References

(Earliest) J:43414 Steinert PM, et al., The complete cDNA and deduced amino acid sequence of a type II mouse epidermal keratin of 60,000 Da: analysis of sequence differences between type I and type II keratins. Proc Natl Acad Sci U S A. 1984 Sep;81(18):5709-13
(Latest) J:192747 Tam C, et al., Cytokeratins mediate epithelial innate defense through their antimicrobial properties. J Clin Invest. 2012 Oct 1;122(10):3665-77
All references(52)

Other accession IDs

MGI:1333767, MGI:1913622