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Krt6a Gene Detail
Summary
  • Symbol
    Krt6a
  • Name
    keratin 6A
  • Synonyms
    Krt2-6a, Krt2-6c, mK6[a], MK6a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100845
    NCBI Gene: 16687
  • Member of
    Krt6 cluster
Location & Maps
more
  • Sequence Map
    Chr15:101689932-101694307 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4376 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 56.97 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    KRT6B, keratin 6B
  • Vertebrate Orthologs
    4
  • Human Ortholog
    KRT6B, keratin 6B
    Orthology source: HomoloGene
  • Synonyms
    CK6B, CK-6B, K6B, KRTL1, PC2, PC4
  • Links
    NCBI Gene ID: 3854
    neXtProt AC: NX_P04259

  • Chr Location
    12q13.13; chr12:52446651-52452126 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human KRT6B associations

Human Disease Mouse Models
       Pachyonychia Congenita 4; PC4   OMIM: 615728
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 6 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    3 images
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Chemically induced (other)
    1
  • Radiation induced
    2
  • Targeted
    5
  • Transgenic
    4
  • Genomic Mutations
    4 involving Krt6a
  • Incidental Mutations
Mice homozygous for a targeted null mutation exhibit delayed wound healing.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000058354 Ensembl Gene Model | MGI Sequence Detail 4376 C57BL/6J ±  kb
transcript ENSMUST00000023788 Ensembl | MGI Sequence Detail 2256 Not Applicable  
polypeptide ENSMUSP00000023788 Ensembl | MGI Sequence Detail 553 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    28 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • InterPro Domains
    IPR001664 Intermediate filament protein
    IPR018039 Intermediate filament protein, conserved site
    IPR003054 Keratin, type II
    IPR032444 Keratin type II head
Molecular
Reagents
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  • All nucleic 47
    Genomic 9
    cDNA 32
    Primer pair 5
    Other 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:1333767, MGI:1913622
References
more
  • Summaries
    All 50
    Developmental Gene Expression 17
    Diseases 2
    Gene Ontology 6
    Phenotypes 30
  • Earliest
    J:43414 Steinert PM, et al., The complete cDNA and deduced amino acid sequence of a type II mouse epidermal keratin of 60,000 Da: analysis of sequence differences between type I and type II keratins. Proc Natl Acad Sci U S A. 1984 Sep;81(18):5709-13
  • Latest
    J:218398 Zuo W, et al., p63(+)Krt5(+) distal airway stem cells are essential for lung regeneration. Nature. 2015 Jan 29;517(7536):616-20

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory