About   Help   FAQ
Krt6a
Gene Detail
 Symbol
Name
ID
Krt6a
keratin 6A
MGI:1100845
Synonyms Krt2-6a, Krt2-6c, mK6[a], MK6a
Feature Type protein coding gene
Genetic Map
Chromosome 15
56.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr15:101689932-101694307 bp, - strand
From Ensembl annotation of GRCm38

  4376 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:136794  Vertebrate Homology Class
1 human; 2 mouse; 1 chimpanzee

Gene Tree: Krt6a

Human
homologs
Human Homolog KRT6B, keratin 6B
NCBI Gene ID 3854
neXtProt AC  NX_P04259
Human Synonyms  CK6B, CK-6B, K6B, KRTL1, PC2, PC4
Human Chr (Location)  12q13.13; chr12:52446651-52452126 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human KRT6B
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null mutation exhibit delayed wound healing.
 
Alleles Annotated to Human Diseases(1)    Phenotype Images(3)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process intermediate filament organization, keratinization, ...
Component extracellular vesicular exosome, intermediate filament, ...
Function structural molecule activity
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (177)    Tissues (65)    Images (34)
Theiler Stages: 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 10
RNA in situ 146
RT-PCR 21
cDNA source data(32)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(45) Genomic(9) cDNA(32) Primer pair(4)
Microarray probesets(6)
Other database
links
Ensembl Gene ModelENSMUSG00000058354 (Evidence)
Entrez Gene16687 (Evidence)
UniGene302399
DFCITC1581306
NIA Mouse Gene IndexU052499
Consensus CDS ProjectCCDS27860.1
International Mouse Knockout Project StatusKrt6a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000058354 Ensembl Gene Model | MGI Sequence Detail 4376 C57BL/6J ±  kb
transcript ENSMUST00000023788 Ensembl | MGI Sequence Detail 2256 Not Applicable 
polypeptide ENSMUSP00000023788 Ensembl | MGI Sequence Detail 553 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(35 from dbSNP Build 137)    SNPs within 2kb including multiple locations(49)
Protein-related
information
ResourceIDDescription
InterPro IPR001664 Intermediate filament protein
InterPro IPR018039 Intermediate filament protein, conserved site
InterPro IPR003054 Type II keratin
Protein Ontology PR:000009482 keratin, type II cytoskeletal 6A
References (Earliest) J:43414 Steinert PM, et al., The complete cDNA and deduced amino acid sequence of a type II mouse epidermal keratin of 60,000 Da: analysis of sequence differences between type I and type II keratins. Proc Natl Acad Sci U S A. 1984 Sep;81(18):5709-13
(Latest) J:192747 Tam C, et al., Cytokeratins mediate epithelial innate defense through their antimicrobial properties. J Clin Invest. 2012 Oct 1;122(10):3665-77
All references(53)
Other
accession IDs
MGI:1333767, MGI:1913622

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/15/2014
MGI 5.18
The Jackson Laboratory