Gfra1
Gene Detail

Symbol

Name
ID

Gfra1
glial cell line derived neurotrophic factor family receptor alpha 1
MGI:1100842

Synonyms

GDNFR-alpha, GFR alpha-1

Feature Type

protein coding gene

Genetic Map

Chromosome 19
54.18 cM, cytoband D2-D3
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr19:58235604-58455909 bp, - strand From VEGA annotation of GRCm38   220306 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:3855  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: GDNF family receptor alpha
Gene Tree: Gfra1

Human
homologs

Human Homolog		GFRA1, GDNF family receptor alpha 1
NCBI Gene ID		2674
neXtProt AC		NX_P56159
Human Synonyms		GDNFR, GDNFRA, GFR-ALPHA-1, RET1L, RETL1, TRNR1
Human Chr (Location)		10q26.11; chr10:116056925-116273614 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(15) : Gene trapped(5) Targeted(9) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygotes for targeted null mutations lack kidneys and enteric neurons resulting in neonatal lethality.

 

Interactions

Gfra1 interacts with 320 markers (Mir7-1, Mir7-2, Mir7b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (19 annotations)

Process	anatomical structure morphogenesis, cell migration, ...
Component	anchored component of membrane, axon, ...
Function	integrin binding, receptor activity

External Resources: FuncBase

Expression

Literature Summary: (80 records)

Data Summary: Results (436)    Tissues (157)    Images (47)    Tissue x Stage Matrix (view)

Assay Type	Results
Immunohistochemistry	6
RNA in situ	391
Northern blot	12
Western blot	3
RT-PCR	24

cDNA source data(73)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(81) cDNA(77) Primer pair(3) Other(1)
Microarray probesets(7)

Other database
links

VEGA Gene Model	OTTMUSG00000033056 (Evidence)
Ensembl Gene Model	ENSMUSG00000025089 (Evidence)
Entrez Gene	14585 (Evidence)
UniGene	88367
DFCI	TC1624130, TC1622983, TC1591397, TC1685391, TC1583543, TC1586575
DoTS	DT.490741, DT.101707585
NIA Mouse Gene Index	U039182
Consensus CDS Project	CCDS38028.1, CCDS70967.1
International Mouse Knockout Project Status	Gfra1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033056	VEGA Gene Model | MGI Sequence Detail	220306	C57BL/6J
transcript	OTTMUST00000082533	VEGA | MGI Sequence Detail	4641	Not Applicable
polypeptide	OTTMUSP00000044237	VEGA | MGI Sequence Detail	468	Not Applicable

All sequences(94) RefSeq(19) UniProt(11)

Polymorphisms

SNPs within 2kb(2402 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR016017	GDNF/GAS1
InterPro	IPR003438	Glial cell line-derived neurotrophic factor receptor
InterPro	IPR003503	Glial cell line-derived neurotrophic factor receptor, alpha 1
InterPro	IPR017372	Glial cell line-derived neurotrophic factor receptor, alpha 1/2
Protein Ontology	PR:000007948	GDNF family receptor alpha-1

References

(Earliest) J:43790 Molliver DC, et al., IB4-binding DRG neurons switch from NGF to GDNF dependence in early postnatal life. Neuron. 1997 Oct;19(4):849-61
(Latest) J:213579 Liao HF, et al., DNMT3L promotes quiescence in postnatal spermatogonial progenitor cells. Development. 2014 Jun;141(12):2402-13
All references(149)

Other
accession IDs

MGI:2147659