Gfra1
Gene Detail

Symbol Name ID

Gfra1 glial cell line derived neurotrophic factor family receptor alpha 1 MGI:1100842

Synonyms

GDNFR-alpha, GFR alpha-1

Feature Type

protein coding gene

Genetic Map

Chromosome 19

54.18 cM, cytoband D2-D3
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr19:58235604-58455909 bp, - strand From VEGA annotation of GRCm38   220306 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3855  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: GDNF family receptor alpha
Gene Tree: Gfra1

Human homologs

Human Homolog		GFRA1, GDNF family receptor alpha 1
NCBI Gene ID		2674
neXtProt AC		NX_P56159
Human Synonyms		GDNFR, GDNFRA, GFR-ALPHA-1, RET1L, RETL1, TRNR1
Human Chr (Location)		10q26.11; chr10:117816436-118033126 (-)  GRCh37.p13

Alleles and phenotypes

All alleles(14) : Targeted(9) Gene trapped(5)
 

Homozygotes for targeted null mutations lack kidneys and enteric neurons resulting in neonatal lethality.

 

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	anatomical structure morphogenesis, cell migration, ...
Component	anchored component of membrane, axon, ...
Function	integrin binding, receptor activity

External Resources: FuncBase

Expression

Literature Summary: (73 records)

Data Summary: Results (437)    Tissues (155)    Images (47)
Theiler Stages: 10, 18, 19, 20, 21, 22, 23, 24, 25, 28

Assay Type	Results
Immunohistochemistry	6
RNA in situ	392
Northern blot	12
Western blot	3
RT-PCR	24

cDNA source data(73)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(81) cDNA(77) Primer pair(3) Other(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000033056 (Evidence)
Ensembl Gene Model	ENSMUSG00000025089 (Evidence)
Entrez Gene	14585 (Evidence)
UniGene	88367
DFCI	TC1583543, TC1586575, TC1591397, TC1622983, TC1624130, TC1685391
DoTS	DT.101707585, DT.490741
NIA Mouse Gene Index	U039182
Consensus CDS Project	CCDS38028.1
International Mouse Knockout Project Status	Gfra1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033056	VEGA Gene Model | MGI Sequence Detail	220306	C57BL/6J
transcript	OTTMUST00000082533	VEGA | MGI Sequence Detail	4641	Not Applicable
polypeptide	OTTMUSP00000044237	VEGA | MGI Sequence Detail	468	Not Applicable

All sequences(88) RefSeq(19) UniProt(6)

Polymorphisms

SNPs within 2kb(2402 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR016017	GDNF/GAS1
InterPro	IPR003438	Glial cell line-derived neurotrophic factor receptor
InterPro	IPR003503	Glial cell line-derived neurotrophic factor receptor, alpha 1
InterPro	IPR017372	Glial cell line-derived neurotrophic factor receptor, alpha 1/2
Protein Ontology	PR:000007948	GDNF family receptor alpha-1

References

(Earliest) J:43790 Molliver DC, et al., IB4-binding DRG neurons switch from NGF to GDNF dependence in early postnatal life. Neuron. 1997 Oct;19(4):849-61
(Latest) J:202753 Uesaka T, et al., GDNF signaling levels control migration and neuronal differentiation of enteric ganglion precursors. J Neurosci. 2013 Oct 9;33(41):16372-82
All references(141)

Other accession IDs

MGI:2147659