Gfra1 MGI Mouse Gene Detail - MGI:1100842 - glial cell line derived neurotrophic factor family receptor alpha 1

Gfra1 Gene Detail

Symbol

Gfra1
Name

glial cell line derived neurotrophic factor family receptor alpha 1
Synonyms

GDNFR-alpha, GFR alpha-1

Feature Type

protein coding gene
IDs

MGI:1100842
NCBI Gene: 14585
Gene Overview

MyGene.info: GFRA1

Sequence Map

Chr19:58235604-58455909 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

220306 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 54.18 cM, cytoband D2-D3
Mapping Data

5 experiments

Human Ortholog

GFRA1, GDNF family receptor alpha 1

Vertebrate Orthologs

10

Human Ortholog

GFRA1, GDNF family receptor alpha 1
Orthology source: HomoloGene, HGNC
Synonyms

GDNFR, GDNFRA, GFR-ALPHA-1, RET1L, RETL1, TRNR1
Links

HGNC:4243

NCBI Gene ID: 2674

neXtProt AC: NX_P56159

UniProt: P56159
Chr Location

10q25.3; chr10:116056925-116273645 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 3855
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed
HCOP

human homology predictions: GFRA1
Protein SuperFamily

GDNF family receptor alpha
Gene Tree

Gfra1

Diseases

1 with Gfra1 mouse models

Human Disease

Mouse Models

Hirschsprung's disease

IDs

View 2 models

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

2 with disease annotations

References

2 with disease annotations

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Phenotype Summary

54 phenotypes from 7 alleles in 8 genetic backgrounds
5 phenotypes from multigenic genotypes
50 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Gene trapped

5
Targeted

12
Transgenic

1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

20 strains or lines available

Homozygotes for targeted null mutations lack kidneys and enteric neurons resulting in neonatal lethality.

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All GO Annotations

21
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

446
Tissues

159
cDNA Data

73
Literature Summary

89

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA GFRA1

Xenbase gfra1

ZFIN gfra1a, gfra1b

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Gfra1 interacts with 319 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

78
RefSeq

13
UniProt

9
CCDS

CCDS38028.1, CCDS70967.1
UniGene

88367

			Length	Strain/Species	Flank
genomic	OTTMUSG00000033056	VEGA Gene Model \| MGI Sequence Detail	220306	C57BL/6J	± kb
transcript	OTTMUST00000082533	VEGA \| MGI Sequence Detail	4641	Not Applicable
polypeptide	OTTMUSP00000044237	VEGA \| MGI Sequence Detail	468	Not Applicable

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SNPs within 2kb

2383 from dbSNP Build 142

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UniProt

9 Sequences
Protein Ontology

PR:000007948 GDNF family receptor alpha-1

(term hierarchy)
InterPro Domains

IPR016017 GDNF/GAS1

IPR003438 Glial cell line-derived neurotrophic factor receptor

IPR003503 Glial cell line-derived neurotrophic factor receptor, alpha 1

IPR017372 Glial cell line-derived neurotrophic factor receptor, alpha 1/2

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All nucleic 82

cDNA 78

Primer pair 3

Other 1

Microarray probesets 7

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MGI:2147659

Summaries

All 160

Developmental Gene Expression 89

Diseases 2

Gene Ontology 6

Phenotypes 50
Earliest

J:43790 Molliver DC, et al., IB4-binding DRG neurons switch from NGF to GDNF dependence in early postnatal life. Neuron. 1997 Oct;19(4):849-61
Latest

J:241573 Pui HP, et al., Gonocytes-to-spermatogonia transition initiates prior to birth in murine testes and it requires FGF signaling. Mech Dev. 2017 Apr;144(Pt B):125-139

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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