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Gfra1
Gene Detail
 Symbol
Name
ID
Gfra1
glial cell line derived neurotrophic factor family receptor alpha 1
MGI:1100842
Synonyms GDNFR-alpha, GFR alpha-1
Feature Type protein coding gene
Genetic Map
Chromosome 19
54.18 cM, cytoband D2-D3
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr19:58235604-58455909 bp, - strand
From VEGA annotation of GRCm38

  220306 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3855  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: GDNF family receptor alpha
Gene Tree: Gfra1

Human
homologs
Human Homolog GFRA1, GDNF family receptor alpha 1
NCBI Gene ID 2674
neXtProt AC  NX_P56159
Human Synonyms  GDNFR, GDNFRA, GFR-ALPHA-1, RET1L, RETL1, TRNR1
Human Chr (Location)  10q26.11; chr10:116056925-116273614 (-)  GRCh38
Alleles
and
phenotypes
All alleles(14) : Gene trapped(5) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations lack kidneys and enteric neurons resulting in neonatal lethality.
 
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process anatomical structure morphogenesis, cell migration, ...
Component anchored component of membrane, axon, ...
Function integrin binding, receptor activity
External Resources: FuncBase
Expression
Literature Summary: (77 records)
Data Summary: Results (437)    Tissues (155)    Images (47)
Theiler Stages: 10, 18, 19, 20, 21, 22, 23, 24, 25, 28
Assay TypeResults
Immunohistochemistry 6
RNA in situ 392
Northern blot 12
Western blot 3
RT-PCR 24
cDNA source data(73)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(81) cDNA(77) Primer pair(3) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000033056 (Evidence)
Ensembl Gene ModelENSMUSG00000025089 (Evidence)
Entrez Gene14585 (Evidence)
UniGene88367
DFCITC1583543, TC1586575, TC1591397, TC1622983, TC1624130, TC1685391
DoTSDT.101707585, DT.490741
NIA Mouse Gene IndexU039182
Consensus CDS ProjectCCDS38028.1, CCDS70967.1
International Mouse Knockout Project StatusGfra1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033056 VEGA Gene Model | MGI Sequence Detail 220306 C57BL/6J ±  kb
transcript OTTMUST00000082533 VEGA | MGI Sequence Detail 4641 Not Applicable 
polypeptide OTTMUSP00000044237 VEGA | MGI Sequence Detail 468 Not Applicable 

For the selected sequences
All sequences(88) RefSeq(19) UniProt(6)
Polymorphisms SNPs within 2kb(2402 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016017 GDNF/GAS1
InterPro IPR003438 Glial cell line-derived neurotrophic factor receptor
InterPro IPR003503 Glial cell line-derived neurotrophic factor receptor, alpha 1
InterPro IPR017372 Glial cell line-derived neurotrophic factor receptor, alpha 1/2
Protein Ontology PR:000007948 GDNF family receptor alpha-1
References (Earliest) J:43790 Molliver DC, et al., IB4-binding DRG neurons switch from NGF to GDNF dependence in early postnatal life. Neuron. 1997 Oct;19(4):849-61
(Latest) J:205498 Tsai SY, et al., Wnt/beta-catenin signaling in dermal condensates is required for hair follicle formation. Dev Biol. 2014 Jan 15;385(2):179-88
All references(145)
Other
accession IDs
MGI:2147659

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory