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Gfra1 Gene Detail
Summary
  • Symbol
    Gfra1
  • Name
    glial cell line derived neurotrophic factor family receptor alpha 1
  • Synonyms
    GDNFR-alpha, GFR alpha-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100842
    NCBI Gene: 14585
  • Gene Overview
    MyGene.info: GFRA1
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr19:58235604-58455909 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      220306 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 54.18 cM, cytoband D2-D3
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    GFRA1, GDNF family receptor alpha 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GFRA1, GDNF family receptor alpha 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GDNFR, GDNFRA, GFR-ALPHA-1, RET1L, RETL1, TRNR1
  • Links
    NCBI Gene ID: 2674
    neXtProt AC: NX_P56159
    UniProt: P56159

  • Chr Location
    10q25.3; chr10:116056925-116273645 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Gfra1 mouse models

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    54 phenotypes from 7 alleles in 8 genetic backgrounds
    5 phenotypes from multigenic genotypes
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations lack kidneys and enteric neurons resulting in neonatal lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    469
  • Tissues
    175
  • cDNA Data
    74
  • Literature Summary
    100
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000033056 VEGA Gene Model | MGI Sequence Detail 220306 C57BL/6J ±  kb
    transcript OTTMUST00000082533 VEGA | MGI Sequence Detail 4641 Not Applicable  
    polypeptide OTTMUSP00000044237 VEGA | MGI Sequence Detail 468 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      2383 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • Protein Ontology
      PR:000007948 GDNF family receptor alpha-1
      (term hierarchy)
    • InterPro Domains
      IPR016017 GDNF/GAS1
      IPR037193 GDNF receptor alpha
      IPR003438 Glial cell line-derived neurotrophic factor receptor
      IPR003503 Glial cell line-derived neurotrophic factor receptor, alpha 1
      IPR017372 Glial cell line-derived neurotrophic factor receptor, alpha 1/2
    Molecular
    Reagents
    less
    • All nucleic 85
      cDNA 79
      Primer pair 5
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:2147659
    References
    more
    • Summaries
      All 177
      Developmental Gene Expression 100
      Diseases 2
      Gene Ontology 5
      Phenotypes 53
    • Earliest
      J:43790 Molliver DC, et al., IB4-binding DRG neurons switch from NGF to GDNF dependence in early postnatal life. Neuron. 1997 Oct;19(4):849-61
    • Latest
      J:262197 Zechel S, et al., Cell-autonomous role of GFRalpha1 in the development of olfactory bulb GABAergic interneurons. Biol Open. 2018 May 18;7(5)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    07/31/2018
    MGI 6.12     		The Jackson Laboratory