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Gfra1 Gene Detail
Summary
  • Symbol
    Gfra1
  • Name
    glial cell line derived neurotrophic factor family receptor alpha 1
  • Synonyms
    GDNFR-alpha, GFR alpha-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100842
    NCBI Gene: 14585
Location & Maps
more
  • Sequence Map
    Chr19:58235604-58455909 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      220306 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    GFRA1, GDNF family receptor alpha 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    GFRA1, GDNF family receptor alpha 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GDNFR, GDNFRA, GFR-ALPHA-1, RET1L, RETL1, TRNR1
  • Links
    NCBI Gene ID: 2674
    neXtProt AC: NX_P56159

  • Chr Location
    10q26.11; chr10:116056925-116273614 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    54 phenotypes from 7 alleles in 8 genetic backgrounds
    5 phenotypes from multigenic genotypes
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    15
  • Gene trapped
    5
  • Targeted
    9
  • Transgenic
    1
  • Incidental Mutations
Homozygotes for targeted null mutations lack kidneys and enteric neurons resulting in neonatal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033056 VEGA Gene Model | MGI Sequence Detail 220306 C57BL/6J ±  kb
transcript OTTMUST00000082533 VEGA | MGI Sequence Detail 4641 Not Applicable  
polypeptide OTTMUSP00000044237 VEGA | MGI Sequence Detail 468 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2402 from dbSNP Build 137
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000007948 GDNF family receptor alpha-1
  • InterPro Domains
    IPR016017 GDNF/GAS1
    IPR003438 Glial cell line-derived neurotrophic factor receptor
    IPR003503 Glial cell line-derived neurotrophic factor receptor, alpha 1
    IPR017372 Glial cell line-derived neurotrophic factor receptor, alpha 1/2
Molecular
Reagents
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  • All nucleic 81
    cDNA 77
    Primer pair 3
    Other 1

    Microarray probesets 7
Other
Accession IDs
less
MGI:2147659
References
more
  • Summaries
    All 150
    Developmental Gene Expression 86
    Gene Ontology 6
    Phenotypes 43
  • Earliest
    J:43790 Molliver DC, et al., IB4-binding DRG neurons switch from NGF to GDNF dependence in early postnatal life. Neuron. 1997 Oct;19(4):849-61
  • Latest
    J:224366 Uesaka T, et al., Neuronal Differentiation in Schwann Cell Lineage Underlies Postnatal Neurogenesis in the Enteric Nervous System. J Neurosci. 2015 Jul 8;35(27):9879-88

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory