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Fgf10
Gene Detail
Symbol

Name
ID
Fgf10
fibroblast growth factor 10
MGI:1099809
Synonyms
AEY17, FGF-10, Gsfaey17
Feature Type
protein coding gene
Genetic Map
Chromosome 13
67.14 cM, cytoband A3-A4
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr13:118669791-118792115 bp, + strand
From VEGA annotation of GRCm38

  122325 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3284  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: FGF10
Gene Tree: Fgf10

Human
homologs
FGF10, fibroblast growth factor 10
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2255
neXtProt AC: NX_O15520

Human Chr (Location): 5p13-p12; chr5:44303541-44389780 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human FGF10

Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Chemically induced (ENU)(2) Gene trapped(4) Targeted(10) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants die at birth with multiple abnormalities including absence of lungs, severely truncated limbs, open eyelids, incomplete external genitalia, arrested pancreatic development, lack of mammary glands and impaired epidermal development.
 
Phenotype Images(6)
Interactions
Fgf10 interacts with 400 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (162 annotations)
Process actin cytoskeleton reorganization, activation of MAPK activity, ...
Component cell, cell surface, ...
Function chemoattractant activity, fibroblast growth factor receptor binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (358 records)
Data Summary: Results (711)    Tissues (432)    Images (195)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 627
Northern blot 17
RT-PCR 65
cDNA source data(32)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase fgf10 ; ZFIN fgf10a, fgf10b    NEW 
Molecular
reagents
All nucleic(83) Genomic(6) cDNA(38) Primer pair(15) Other(24)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000032890 (Evidence)
Ensembl Gene Model ENSMUSG00000021732 (Evidence)
Entrez Gene 14165 (Evidence)
UniGene 317323
DFCI TC1698613, TC1582601, TC1624015
DoTS DT.55225631
NIA Mouse Gene Index U015282
Consensus CDS Project CCDS26795.1
International Mouse Phenotyping Consortium Status Fgf10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032890 VEGA Gene Model | MGI Sequence Detail 122325 C57BL/6J ±  kb
transcript OTTMUST00000081954 VEGA | MGI Sequence Detail 4114 Not Applicable 
polypeptide OTTMUSP00000043898 VEGA | MGI Sequence Detail 209 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(1183 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008996 Cytokine, IL-1-like
InterPro IPR002209 Heparin-binding growth factor/Fibroblast growth factor
Protein Ontology PR:000007480 fibroblast growth factor 10
References
(Earliest) J:31907 Vainio S, et al., Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development. Cell. 1993 Oct 8;75(1):45-58
(Latest) J:221201 Lahtela J, et al., The putative tumor suppressor gene EphA3 fails to demonstrate a crucial role in murine lung tumorigenesis or morphogenesis. Dis Model Mech. 2015 Apr;8(4):393-401
All references(469)
Other
accession IDs
MGI:2145479, MGI:3529962

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory