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Fgf10
Gene Detail
 Symbol
Name
ID
Fgf10
fibroblast growth factor 10
MGI:1099809
Synonyms AEY17, FGF-10, Gsfaey17
Feature Type protein coding gene
Genetic Map
Chromosome 13
67.14 cM, cytoband A3-A4
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr13:118669791-118792115 bp, + strand
From VEGA annotation of GRCm38

  122325 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3284  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Fgf10

Human
homologs
Human Homolog FGF10, fibroblast growth factor 10
NCBI Gene ID 2255
neXtProt AC  NX_O15520
Human Chr (Location)  5p13-p12; chr5:44304902-44389706 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human FGF10
Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Chemically induced (ENU)(2) Gene trapped(4) Targeted(10) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants die at birth with multiple abnormalities including absence of lungs, severely truncated limbs, open eyelids, incomplete external genitalia, arrested pancreatic development, lack of mammary glands and impaired epidermal development.
 
Human Diseases Modeled Using Mouse Fgf10 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(6)
Interactions
Fgf10 interacts with 401 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (162 annotations)
Process actin cytoskeleton reorganization, activation of MAPK activity, ...
Component cell, cell surface, ...
Function chemoattractant activity, fibroblast growth factor receptor binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (339 records)
Data Summary: Results (669)    Tissues (426)    Images (178)
Theiler Stages: 2, 3, 4, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 593
Northern blot 17
RT-PCR 57
cDNA source data(32)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(79) Genomic(6) cDNA(38) Primer pair(13) Other(22)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000032890 (Evidence)
Ensembl Gene ModelENSMUSG00000021732 (Evidence)
Entrez Gene14165 (Evidence)
UniGene317323
DFCITC1582601, TC1624015, TC1698613
DoTSDT.55225631
NIA Mouse Gene IndexU015282
Consensus CDS ProjectCCDS26795.1
International Mouse Knockout Project StatusFgf10
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032890 VEGA Gene Model | MGI Sequence Detail 122325 C57BL/6J ±  kb
transcript OTTMUST00000081954 VEGA | MGI Sequence Detail 4114 Not Applicable 
polypeptide OTTMUSP00000043898 VEGA | MGI Sequence Detail 209 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(2) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(1183 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008996 Cytokine, IL-1-like
InterPro IPR002209 Heparin-binding growth factor/Fibroblast growth factor
Protein Ontology PR:000007480 fibroblast growth factor 10
References (Earliest) J:31907 Vainio S, et al., Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development. Cell. 1993 Oct 8;75(1):45-58
(Latest) J:208417 Carraro G, et al., miR-142-3p balances proliferation and differentiation of mesenchymal cells during lung development. Development. 2014 Mar;141(6):1272-81
All references(447)
Disease annotation references (1)
Other
accession IDs
MGI:2145479, MGI:3529962

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/16/2014
MGI 5.19
The Jackson Laboratory