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Fgf10 Gene Detail
Summary
  • Symbol
    Fgf10
  • Name
    fibroblast growth factor 10
  • Synonyms
    AEY17, FGF-10, Gsfaey17
  • Feature Type
    protein coding gene
  • IDs
    MGI:1099809
    NCBI Gene: 14165
Location & Maps
more
  • Sequence Map
    Chr13:118669791-118792115 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      122325 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    FGF10, fibroblast growth factor 10
  • Vertebrate Orthologs
    11
  • Human Ortholog
    FGF10, fibroblast growth factor 10
    Orthology source: HomoloGene
  • Links
    NCBI Gene ID: 2255
    neXtProt AC: NX_O15520

  • Chr Location
    5p13-p12; chr5:44303541-44389780 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 3284
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: FGF10
  • Gene Tree
Human Diseases
more
  • Diseases
    2 with human FGF10 associations

Human Disease Mouse Models
       Aplasia of Lacrimal and Salivary Glands; ALSG   OMIM: 180920
Lacrimoauriculodentodigital Syndrome; LADD   OMIM: 149730
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    133 phenotypes from 8 alleles in 12 genetic backgrounds
    43 phenotypes from multigenic genotypes
    6 images
    120 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    19
  • Chemically induced (ENU)
    2
  • Gene trapped
    4
  • Targeted
    11
  • Transgenic
    2
  • Incidental Mutations
Homozygous mutants die at birth with multiple abnormalities including absence of lungs, severely truncated limbs, open eyelids, incomplete external genitalia, arrested pancreatic development, lack of mammary glands and impaired epidermal development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000032890 VEGA Gene Model | MGI Sequence Detail 122325 C57BL/6J ±  kb
transcript OTTMUST00000081954 VEGA | MGI Sequence Detail 4114 Not Applicable  
polypeptide OTTMUSP00000043898 VEGA | MGI Sequence Detail 209 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1183 from dbSNP Build 137
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 86
    Genomic 6
    cDNA 39
    Primer pair 15
    Other 26

    Microarray probesets 5
Other
Accession IDs
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MGI:2145479, MGI:3529962
References
more
  • Summaries
    All 478
    Developmental Gene Expression 369
    Gene Ontology 59
    Phenotypes 120
  • Earliest
    J:31907 Vainio S, et al., Identification of BMP-4 as a signal mediating secondary induction between epithelial and mesenchymal tissues during early tooth development. Cell. 1993 Oct 8;75(1):45-58
  • Latest
    J:226857 Yang Y, et al., Lhx9 gene expression during early limb development in mice requires the FGF signalling pathway. Gene Expr Patterns. 2015 Sep-Nov;19(1-2):45-51

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory