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Odf2 Gene Detail
Summary
  • Symbol
    Odf2
  • Name
    outer dense fiber of sperm tails 2
  • Synonyms
    cenexin, MMTEST29
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098824
    NCBI Gene: 18286
  • Gene Overview
    MyGene.info: ODF2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:29889221-29931746 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      42526 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 20.79 cM, cytoband B
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    ODF2, outer dense fiber of sperm tails 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    ODF2, outer dense fiber of sperm tails 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CT134, ODF2/1, ODF2/2, ODF84
  • Links
    NCBI Gene ID: 4957
    neXtProt AC: NX_Q5BJF6
    UniProt: Q5BJF6

  • Chr Location
    9q34.11; chr9:128455155-128501292 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 4 alleles in 4 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele exhibit embryonic lethality before implantation and transmission ratio distortion while all heterozygous males display normal development and fertility. Males heterozygous for other alleles are either infertile orshow reduced fertility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000019165 VEGA Gene Model | MGI Sequence Detail 42526 C57BL/6J ±  kb
    transcript OTTMUST00000040452 VEGA | MGI Sequence Detail 3188 Not Applicable  
    polypeptide OTTMUSP00000018076 VEGA | MGI Sequence Detail 830 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      98 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 14
      Primer pair 3

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:2139073
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 7
      Gene Ontology 10
      Phenotypes 13
    • Earliest
      J:42726 Nakayama H, et al., Developmental restriction of Mash-2 expression in trophoblast correlates with potential activation of the notch-2 pathway. Dev Genet. 1997;21(1):21-30
    • Latest
      J:240026 Minegishi K, et al., A Wnt5 Activity Asymmetry and Intercellular Signaling via PCP Proteins Polarize Node Cells for Left-Right Symmetry Breaking. Dev Cell. 2017 Mar 13;40(5):439-452.e4

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory