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Sepsecs
Gene Detail
Symbol

Name
ID
Sepsecs
Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
MGI:1098791
Synonyms
D5Ertd135e, SecS, SLA
Feature Type
protein coding gene
Genetic Map
Chromosome 5
28.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:52640087-52669729 bp, - strand
From VEGA annotation of GRCm38

  29643 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:15031  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SEPSECS
Protein SuperFamily: O-phosphoseryl-tRNA(Sec) selenium transferase
Gene Tree: Sepsecs

Human
homologs
SEPSECS, Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 51091
neXtProt AC: NX_Q9HD40

Human Synonyms: LP, PCH2D, SLA, SLA/LP

Human Chr (Location): 4p15.2; chr4:25120005-25160582 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SEPSECS

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Radiation induced(1) Targeted(2)
Genomic Mutations involving Sepsecs (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Phenotype Images(4)
Interactions
Sepsecs interacts with 437 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process selenocysteine incorporation, selenocysteinyl-tRNA(Sec) biosynthetic process, ...
Component cytoplasm, nucleus
Function catalytic activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (168)    Tissues (101)    Images (31)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 168
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase sepsecs ; ZFIN sepsecs    NEW 
Molecular
reagents
All nucleic(13) cDNA(12) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000023343 (Evidence)
Ensembl Gene Model ENSMUSG00000029173 (Evidence)
Entrez Gene 211006 (Evidence)
DFCI TC1601762, TC1583817, TC1688824
DoTS DT.101272758, DT.530168, DT.99857312
NIA Mouse Gene Index U026206
EC 2.9.1.2
PDB 3BCB, 3BCA, 3BC8
Consensus CDS Project CCDS19286.1
International Mouse Phenotyping Consortium Status Sepsecs
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023343 VEGA Gene Model | MGI Sequence Detail 29643 C57BL/6J ±  kb
transcript OTTMUST00000056604 VEGA | MGI Sequence Detail 5273 Not Applicable 
polypeptide OTTMUSP00000027225 VEGA | MGI Sequence Detail 504 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(5) UniProt(5)
Polymorphisms
SNPs within 2kb(304 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019872 O-phosphoseryl-tRNA(Sec) selenium transferase
InterPro IPR015424 Pyridoxal phosphate-dependent transferase
InterPro IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1
InterPro IPR008829 Soluble liver antigen/liver pancreas antigen
Protein Ontology PR:000014647 O-phosphoseryl-tRNA(Sec) selenium transferase
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(36)
Other
accession IDs
MGI:2140795

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory