About   Help   FAQ
Sepsecs
Gene Detail
 Symbol
Name
ID
Sepsecs
Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
MGI:1098791
Synonyms D5Ertd135e, SecS, SLA
Feature Type protein coding gene
Genetic Map
Chromosome 5
28.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:52640087-52669729 bp, - strand
From VEGA annotation of GRCm38

  29643 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:15031  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: O-phosphoseryl-tRNA(Sec) selenium transferase
Gene Tree: Sepsecs

Human
homologs
Human Homolog SEPSECS, Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
NCBI Gene ID 51091
neXtProt AC  NX_Q9HD40
Human Synonyms  LP, PCH2D, SLA, SLA/LP
Human Chr (Location)  4p15.2; chr4:25120005-25160582 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SEPSECS
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(2) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Sepsecs interacts with 438 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process selenocysteine incorporation, selenocysteinyl-tRNA(Sec) biosynthetic process, ...
Component cytoplasm, nucleus
Function catalytic activity, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (168)    Tissues (101)    Images (31)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 168
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(12) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000023343 (Evidence)
Ensembl Gene ModelENSMUSG00000029173 (Evidence)
Entrez Gene211006 (Evidence)
DFCITC1583817, TC1601762, TC1688824
DoTSDT.101272758, DT.530168, DT.99857312
NIA Mouse Gene IndexU026206
EC2.9.1.2
PDB3BCA, 3BCB, 3BC8
Consensus CDS ProjectCCDS19286.1
International Mouse Knockout Project StatusSepsecs
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023343 VEGA Gene Model | MGI Sequence Detail 29643 C57BL/6J ±  kb
transcript OTTMUST00000056604 VEGA | MGI Sequence Detail 5273 Not Applicable 
polypeptide OTTMUSP00000027225 VEGA | MGI Sequence Detail 504 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(5) UniProt(5)
Polymorphisms SNPs within 2kb(304 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019872 O-phosphoseryl-tRNA(Sec) selenium transferase
InterPro IPR015424 Pyridoxal phosphate-dependent transferase
InterPro IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1
InterPro IPR008829 Soluble liver antigen/liver pancreas antigen
Protein Ontology PR:000014647 O-phosphoseryl-tRNA(Sec) selenium transferase
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(37)
Other
accession IDs
MGI:2140795

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/19/2014
MGI 5.19
The Jackson Laboratory