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Sepsecs Gene Detail
Summary
  • Symbol
    Sepsecs
  • Name
    Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
  • Synonyms
    D5Ertd135e, SecS, SLA
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098791
    NCBI Gene: 211006
  • Gene Overview
    MyGene.info: SEPSECS
Location & Maps
more
  • Sequence Map
    Chr5:52640087-52669708 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      29622 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 28.44 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SEPSECS, Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SEPSECS, Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LP, PCH2D, SLA, SLA/LP
  • Links
    NCBI Gene ID: 51091
    neXtProt AC: NX_Q9HD40

  • Chr Location
    4p15.2; chr4:25120005-25160582 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human SEPSECS associations

Human Disease Mouse Models
       Pontocerebellar Hypoplasia, Type 2D; PCH2D   OMIM: 613811
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotype references
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    2
  • Gene trapped
    2
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    2
  • Genomic Mutations
    4 involving Sepsecs
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023343 VEGA Gene Model | MGI Sequence Detail 29622 C57BL/6J ±  kb
transcript OTTMUST00000056604 VEGA | MGI Sequence Detail 5252 Not Applicable  
polypeptide OTTMUSP00000027225 VEGA | MGI Sequence Detail 504 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    303 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000014647 O-phosphoseryl-tRNA(Sec) selenium transferase
  • PDB
  • EC
  • InterPro Domains
    IPR019872 O-phosphoseryl-tRNA(Sec) selenium transferase
    IPR015424 Pyridoxal phosphate-dependent transferase
    IPR015421 Pyridoxal phosphate-dependent transferase, major region, subdomain 1
    IPR008829 SepSecS/SepCysS family
Molecular
Reagents
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  • All nucleic 13
    cDNA 12
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGI:2140795
References
more
  • Summaries
    All 33
    Developmental Gene Expression 2
    Gene Ontology 3
    Phenotypes 21
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory