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Acaa2
Gene Detail
Symbol

Name
ID
Acaa2
acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)
MGI:1098623
Synonyms
0610011L04Rik, D18Ertd240e
Feature Type
protein coding gene
Genetic Map
Chromosome 18
50.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr18:74779212-74806207 bp, + strand
From NCBI annotation of GRCm38

  26996 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4456  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ACAA2
Protein SuperFamily: acetyl-CoA acetyltransferase
Gene Tree: Acaa2

Human
homologs
ACAA2, acetyl-CoA acyltransferase 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 10449
neXtProt AC: NX_P42765

Human Synonyms: DSAEC

Human Chr (Location): 18q21.1; chr18:49783504-49813881 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(5)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Acaa2 interacts with 43 markers (Mir23a, Mir23b, Mir101a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (4 records)
Data Summary: Results (240)    Tissues (131)    Images (45)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 240
cDNA source data(362)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase acaa2 ; ZFIN acaa2    NEW 
Molecular
reagents
All nucleic(364) cDNA(362) Primer pair(2)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000036880 (Evidence)
Entrez Gene 52538 (Evidence)
UniGene 245724
DFCI TC1573252
DoTS DT.99868467, DT.101370397
NIA Mouse Gene Index U018898
EC 2.3.1.16
Consensus CDS Project CCDS29342.1
International Mouse Phenotyping Consortium Status Acaa2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 52538 NCBI Gene Model | MGI Sequence Detail 26996 C57BL/6J ±  kb
transcript NM_177470 RefSeq | MGI Sequence Detail 1500 C57BL/6 
polypeptide Q8BWT1 UniProt | EBI | MGI Sequence Detail 397 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(211 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002155 Thiolase
InterPro IPR020610 Thiolase, active site
InterPro IPR020615 Thiolase, acyl-enzyme intermediate active site
InterPro IPR020613 Thiolase, conserved site
InterPro IPR020617 Thiolase, C-terminal
InterPro IPR016039 Thiolase-like
InterPro IPR016038 Thiolase-like, subgroup
InterPro IPR020616 Thiolase, N-terminal
Protein Ontology PR:000003595 3-ketoacyl-CoA thiolase, mitochondrial
Graphical View of Protein Domain Structure
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:193325 Boj SF, et al., Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Cell. 2012 Dec 21;151(7):1595-607
All references(37)
Other
accession IDs
MGI:1915593, MGI:2147202, MGI:2147205

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory