Acaa2 MGI Mouse Gene Detail - MGI:1098623 - acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)

Acaa2 Gene Detail

Symbol

Acaa2
Name

acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)
Synonyms

0610011L04Rik, D18Ertd240e

Human Ortholog

ACAA2, acetyl-CoA acyltransferase 2
Orthology source: HomoloGene, HGNC
Synonyms

DSAEC
Links

HGNC:83

NCBI Gene ID: 10449

neXtProt AC: NX_P42765

UniProt: P42765
Chr Location

18q21.1; chr18:49783504-49813881 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 4456
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: ACAA2
Protein SuperFamily

acetyl-CoA acetyltransferase
Gene Tree

Acaa2

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Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

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			Length	Strain/Species	Flank
genomic	52538	NCBI Gene Model \| MGI Sequence Detail	26996	C57BL/6J	± kb
transcript	NM_177470	RefSeq \| MGI Sequence Detail	1500	C57BL/6
polypeptide	Q8BWT1	UniProt \| EBI \| MGI Sequence Detail	397	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000003595 3-ketoacyl-CoA thiolase, mitochondrial

(term hierarchy)
EC

2.3.1.16
InterPro Domains

IPR002155 Thiolase

IPR020610 Thiolase, active site

IPR020615 Thiolase, acyl-enzyme intermediate active site

IPR020613 Thiolase, conserved site

IPR020617 Thiolase, C-terminal

IPR016039 Thiolase-like

IPR020616 Thiolase, N-terminal

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MGI:1915593, MGI:2147202, MGI:2147205

Summaries

All 40

Developmental Gene Expression 4

Gene Ontology 8

Phenotypes 6
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:235036 Tomilov A, et al., p46Shc Inhibits Thiolase and Lipid Oxidation in Mitochondria. J Biol Chem. 2016 Jun 10;291(24):12575-85

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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