Acaa2
Gene Detail

Symbol

Name
ID

Acaa2
acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)
MGI:1098623

Synonyms

0610011L04Rik, D18Ertd240e

Feature Type

protein coding gene

Genetic Map

Chromosome 18
50.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr18:74779212-74806207 bp, + strand From NCBI annotation of GRCm38   26996 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:4456  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: acetyl-CoA acetyltransferase
Gene Tree: Acaa2

Human
homologs

Human Homolog		ACAA2, acetyl-CoA acyltransferase 2
NCBI Gene ID		10449
neXtProt AC		NX_P42765
Human Synonyms		DSAEC
Human Chr (Location)		18q21.1; chr18:49783504-49813881 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(5) : Gene trapped(5)
Incidental mutations (data from Mutagenetix , APF )

Interactions

Acaa2 interacts with 43 markers (Mir23a, Mir23b, Mir101a, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (20 annotations)

Process	acetyl-CoA metabolic process, cellular response to hypoxia, ...
Component	extracellular vesicular exosome, mitochondrial inner membrane, ...
Function	acetyl-CoA C-acyltransferase activity, catalytic activity, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)

Data Summary: Results (240)    Tissues (131)    Images (45)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	240

cDNA source data(362)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas

Molecular
reagents

All nucleic(364) cDNA(362) Primer pair(2)
Microarray probesets(4)

Other database
links

Ensembl Gene Model	ENSMUSG00000036880 (Evidence)
Entrez Gene	52538 (Evidence)
UniGene	245724
DFCI	TC1573252
DoTS	DT.99868467, DT.101370397
NIA Mouse Gene Index	U018898
EC	2.3.1.16
Consensus CDS Project	CCDS29342.1
International Mouse Knockout Project Status	Acaa2

Sequences

Length	Strain/Species
genomic	52538	NCBI Gene Model | MGI Sequence Detail	26996	C57BL/6J
transcript	NM_177470	RefSeq | MGI Sequence Detail	1500	C57BL/6
polypeptide	Q8BWT1	UniProt | EBI | MGI Sequence Detail	397	Not Applicable

All sequences(27) RefSeq(2) UniProt(2)

Polymorphisms

SNPs within 2kb(211 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR002155	Thiolase
InterPro	IPR020610	Thiolase, active site
InterPro	IPR020615	Thiolase, acyl-enzyme intermediate active site
InterPro	IPR020613	Thiolase, conserved site
InterPro	IPR020617	Thiolase, C-terminal
InterPro	IPR016039	Thiolase-like
InterPro	IPR016038	Thiolase-like, subgroup
InterPro	IPR020616	Thiolase, N-terminal
Protein Ontology	PR:000003595	3-ketoacyl-CoA thiolase, mitochondrial

Graphical View of Protein Domain Structure

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:193325 Boj SF, et al., Diabetes risk gene and Wnt effector Tcf7l2/TCF4 controls hepatic response to perinatal and adult metabolic demand. Cell. 2012 Dec 21;151(7):1595-607
All references(38)

Other
accession IDs

MGI:1915593, MGI:2147202, MGI:2147205