Acaa2 MGI Mouse Gene Detail - MGI:1098623 - acetyl-CoA acyltransferase 2

Symbol

Acaa2
Name

acetyl-CoA acyltransferase 2
Synonyms

0610011L04Rik, D18Ertd240e

Feature Type

protein coding gene
IDs

MGI:1098623
NCBI Gene: 52538
Alliance

genome feature page
Transcription Start Sites

8 TSS

Sequence Map

Chr18:74912283-74939278 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 18, 50.76 cM
Mapping Data

4 experiments

SNPs within 2kb

993 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1098623	protein coding gene	Chr18:74912268-74939279 (+)
129S1/SvImJ	ENSMUSG00200026650	protein coding gene	Chr18:72124164-72151183 (+)
A/J	ENSMUSG00195004775	protein coding gene	Chr18:72196068-72223098 (+)
AKR/J	ENSMUSG00220016995	protein coding gene	Chr18:72116222-72144052 (+)
BALB/cJ	ENSMUSG00180013230	protein coding gene	Chr18:72772621-72799655 (+)
C3H/HeJ	ENSMUSG00175012450	protein coding gene	Chr18:72324720-72351788 (+)
C57BL/6NJ	ENSMUSG00215018254	protein coding gene	Chr18:71675478-71702509 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022402	protein coding gene	Chr18:71190250-71220125 (+)
CAST/EiJ	ENSTCUG00005027746	protein coding gene	Chr18:71236113-71263322 (+)
CBA/J	ENSMUSG00210030622	protein coding gene	Chr18:72282209-72309269 (+)
DBA/2J	ENSMUSG00185010790	protein coding gene	Chr18:72188388-72215451 (+)
FVB/NJ	ENSMUSG00205012877	protein coding gene	Chr18:71797918-71824852 (+)
JF1/MsJ	ENSUMUG00000025158	protein coding gene	Chr18:72098615-72126407 (+)
LP/J	ENSMUSG00230011125	protein coding gene	Chr18:74247652-74274673 (+)
NOD/ShiLtJ	ENSMUSG00190019998	protein coding gene	Chr18:71941598-71968624 (+)
NZO/HlLtJ	ENSMUSG00225033144	protein coding gene	Chr18:74099224-74126142 (+)
PWK/PhJ	ENSLUMG00010006240	protein coding gene	Chr18:72509524-72536603 (+)
SPRET/EiJ	ENSMSPG00010008645	protein coding gene	Chr18:72747878-72774509 (+)
WSB/EiJ	ENSIUOG00005007390	protein coding gene	Chr18:71727884-71754900 (+)

Human Ortholog

ACAA2, acetyl-CoA acyltransferase 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ACAA2, acetyl-CoA acyltransferase 2
Synonyms

DSAEC, T1
Links

HGNC:83

NCBI Gene ID: 10449

UniProt: P42765
Chr Location

18q21.1; chr18:49782164-49813953 (-) GRCh38

MGI Vertebrate Homology

Acaa2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ACAA2
Protein SuperFamily

Ac-CoA_Ac_transf
Gene Tree

Acaa2

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

6
Gene trapped

5
Transposon induced

1
Genomic Mutations

1 involving Acaa2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

25 strains or lines available

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All GO Annotations

51
GO References

14

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

839
Tissues

132
cDNA Data

363
Literature Summary

7

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase acaa2

ZFIN acaa2

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All Sequences

45
RefSeq

2
UniProt

3
CCDS

CCDS29342.1

Ensembl

ENSMUSG00000036880 (Evidence)
NCBI Gene

52538

			Length	Strain/Species	Flank
genomic	52538	NCBI Gene Model \| MGI Sequence Detail	26996	C57BL/6J	± kb
transcript	NM_177470	RefSeq \| MGI Sequence Detail	1500	ZRU/MplStud
polypeptide	Q8BWT1	UniProt \| EBI \| MGI Sequence Detail	397	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000003595 3-ketoacyl-CoA thiolase, mitochondrial

(term hierarchy)
EC

2.3.1.16, 2.3.1.9, 3.1.2.-, 3.1.2.1, 3.1.2.2
InterPro Domains

IPR002155 Thiolase

IPR020610 Thiolase, active site

IPR020615 Thiolase, acyl-enzyme intermediate active site

IPR020613 Thiolase, conserved site

IPR020617 Thiolase, C-terminal

IPR016039 Thiolase-like

IPR020616 Thiolase, N-terminal
GlyGen

Q8BWT1 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 366

cDNA 363

Primer pair 3

Microarray probesets 4

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MGI:1915593, MGI:2147202, MGI:2147205

Summaries

All 58

Developmental Gene Expression 7

Gene Ontology 14

Phenotypes 12
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:355450 Huang X, et al., Cullin-associated and neddylation-dissociated protein 1 (CAND1) alleviates NAFLD by reducing ubiquitinated degradation of ACAA2. Nat Commun. 2023 Aug 1;14(1):4620

TSS for Acaa2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr151937	Chr18:74912249-74912260 (+)	-28 bp
Tssr151938	Chr18:74912261-74912270 (+)	-17 bp
Tssr151939	Chr18:74912274-74912295 (+)	2 bp
Tssr151940	Chr18:74920154-74920171 (+)	7,880 bp
Tssr151941	Chr18:74920175-74920194 (+)	7,902 bp
Tssr151942	Chr18:74920207-74920219 (+)	7,930 bp
Tssr151943	Chr18:74925486-74925499 (+)	13,210 bp
Tssr151944	Chr18:74930063-74930111 (+)	17,804 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/08/2026 MGI 6.24