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Acaa2 Gene Detail
Summary
  • Symbol
    Acaa2
  • Name
    acetyl-Coenzyme A acyltransferase 2 (mitochondrial 3-oxoacyl-Coenzyme A thiolase)
  • Synonyms
    0610011L04Rik, D18Ertd240e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098623
    NCBI Gene: 52538
  • Gene Overview
    MyGene.info: ACAA2
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:74912283-74939278 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 50.76 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    200 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098623
 protein coding gene Chr18:74912268-74939279 (+)
129S1/SvImJ MGP_129S1SvImJ_G0024559
 protein coding gene Chr18:75426210-75456865 (+)
A/J MGP_AJ_G0024526
 protein coding gene Chr18:72139491-72167084 (+)
AKR/J MGP_AKRJ_G0024497
 protein coding gene Chr18:74263325-74293457 (+)
BALB/cJ MGP_BALBcJ_G0024526
 protein coding gene Chr18:72335512-72362778 (+)
C3H/HeJ MGP_C3HHeJ_G0024294
 protein coding gene Chr18:74372477-74405941 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024972
 protein coding gene Chr18:77396621-77428582 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022402
 protein coding gene Chr18:71190250-71220125 (+)
CAST/EiJ MGP_CASTEiJ_G0023767
 protein coding gene Chr18:74543115-74571256 (+)
CBA/J MGP_CBAJ_G0024263
 protein coding gene Chr18:80046996-80077101 (+)
DBA/2J MGP_DBA2J_G0024393
 protein coding gene Chr18:71734156-71761063 (+)
FVB/NJ MGP_FVBNJ_G0024359
 protein coding gene Chr18:71065024-71093559 (+)
LP/J MGP_LPJ_G0024477
 protein coding gene Chr18:75292899-75321407 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024389
 protein coding gene Chr18:81500111-81530432 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025020
 protein coding gene Chr18:74417273-74443941 (+)
PWK/PhJ MGP_PWKPhJ_G0023511
 protein coding gene Chr18:72100720-72128258 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023315
 protein coding gene Chr18:74542710-74570266 (+)
WSB/EiJ MGP_WSBEiJ_G0023830
 protein coding gene Chr18:74351471-74381337 (+)



Homology
more
  • Human Ortholog
    ACAA2, acetyl-CoA acyltransferase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ACAA2, acetyl-CoA acyltransferase 2
  • Synonyms
    DSAEC
  • Links
    NCBI Gene ID: 10449
    neXtProt AC: NX_P42765
    UniProt: P42765

  • Chr Location
    18q21.1; chr18:49783504-49813881 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    28
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    912
  • Tissues
    131
  • cDNA Data
    363
  • Literature Summary
    4
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 52538 NCBI Gene Model | MGI Sequence Detail 26996 C57BL/6J ±  kb
transcript NM_177470 RefSeq | MGI Sequence Detail 1500 C57BL/6  
polypeptide Q8BWT1 UniProt | EBI | MGI Sequence Detail 397 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 365
    cDNA 363
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:1915593, MGI:2147202, MGI:2147205
References
more
  • Summaries
    All 41
    Developmental Gene Expression 4
    Gene Ontology 9
    Phenotypes 6
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:235036 Tomilov A, et al., p46Shc Inhibits Thiolase and Lipid Oxidation in Mitochondria. J Biol Chem. 2016 Jun 10;291(24):12575-85
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/12/2021
MGI 6.17 		The Jackson Laboratory