Jag2
Gene Detail

Symbol Name ID

Jag2 jagged 2 MGI:1098270

Synonyms

D12Ggc2e, Serh

Feature Type

protein coding gene

Genetic Map

Chromosome 12

61.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr12:112908590-112929495 bp, - strand From NCBI annotation of GRCm38   20906 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1677  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Jag2

Human homologs

Human Homolog		JAG2, jagged 2
NCBI Gene ID		3714
neXtProt AC		NX_Q9Y219
Human Synonyms		HJ2, SER2
Human Chr (Location)		14q32; chr14:105607318-105635161 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(5) Spontaneous(1)
 

Homozygotes for a targeted null mutation die perinatally with craniofacial defects, fused digits, and increased numbers of sensory hair cells in the cochlea. Homozygotes for a spontaneous mutation exhibit fused digits and sometimes tail kinks.

 
Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (33 annotations)

Process	auditory receptor cell fate commitment, cell communication, ...
Component	integral to membrane, integral to plasma membrane, ...
Function	calcium ion binding, growth factor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (89 records)
Data Summary: Results (238)    Tissues (102)    Images (51)
Theiler Stages: 1, 2, 3, 4, 5, 15, 17, 18, 19, 20, 21, 23, 24, 25, 28

Assay Type	Results
RNA in situ	183
RT-PCR	55

cDNA source data(59)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(77) Genomic(8) cDNA(60) Primer pair(5) Other(4)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000002799 (Evidence)
Entrez Gene	16450 (Evidence)
UniGene	186146
DFCI	TC1579775, TC1599124
DoTS	DT.526069, DT.55150677
NIA Mouse Gene Index	U034394
Consensus CDS Project	CCDS26200.1
International Mouse Knockout Project Status	Jag2

Sequences

Length	Strain/Species
genomic	16450	NCBI Gene Model | MGI Sequence Detail	20906	C57BL/6J
transcript	NM_010588	RefSeq | MGI Sequence Detail	4054	Not Specified
polypeptide	Q9QYE5	UniProt | EBI | MGI Sequence Detail	1247	Not Applicable

All sequences(23) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(125 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001774	Delta/Serrate/lag-2 (DSL) protein
InterPro	IPR001881	EGF-like calcium-binding
InterPro	IPR018097	EGF-like calcium-binding, conserved site
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000152	EGF-type aspartate/asparagine hydroxylation site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR026219	Jagged/Serrate protein
InterPro	IPR011651	Notch ligand, N-terminal
InterPro	IPR001007	von Willebrand factor, type C
Protein Ontology	PR:000009194	protein jagged-2

Graphical View of Protein Domain Structure

References

(Earliest) J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54:113-145
(Latest) J:194050 Massa F, et al., Hepatocyte nuclear factor 1beta controls nephron tubular development. Development. 2013 Feb;140(4):886-96
All references(137)

Other accession IDs

MGD-MRK-14445, MGD-MRK-36557, MGD-MRK-39539, MGI:107977, MGI:109540, MGI:98321