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Jag2
Gene Detail
Symbol

Name
ID
Jag2
jagged 2
MGI:1098270
Synonyms
D12Ggc2e, Serh
Feature Type
protein coding gene
Genetic Map
Chromosome 12
61.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr12:112908590-112929495 bp, - strand
From Ensembl annotation of GRCm38

  20906 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1677  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Jag2

Human
homologs
Human Homolog JAG2, jagged 2
NCBI Gene ID 3714
neXtProt AC  NX_Q9Y219
Human Synonyms  HJ2, SER2
Human Chr (Location)  14q32; chr14:105140981-105168824 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Spontaneous(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation die perinatally with craniofacial defects, fused digits, and increased numbers of sensory hair cells in the cochlea. Homozygotes for a spontaneous mutation exhibit fused digits and sometimes tail kinks.
 
Phenotype Images(1)
Interactions
Jag2 interacts with 110 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (94 records)
Data Summary: Results (247)    Tissues (106)    Images (64)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 194
RT-PCR 53
cDNA source data(59)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(79) Genomic(8) cDNA(61) Primer pair(5) Other(5)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000002799 (Evidence)
Entrez Gene16450 (Evidence)
UniGene186146
DFCITC1599124, TC1579775
DoTSDT.55150677, DT.526069
NIA Mouse Gene IndexU034394
Consensus CDS ProjectCCDS26200.1
International Mouse Knockout Project StatusJag2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000002799 Ensembl Gene Model | MGI Sequence Detail 20906 C57BL/6J ±  kb
transcript ENSMUST00000075827 Ensembl | MGI Sequence Detail 4054 Not Applicable 
polypeptide ENSMUSP00000075224 Ensembl | MGI Sequence Detail 1247 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(9) UniProt(7)
Polymorphisms
RFLP(1) : SNPs within 2kb(159 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001774 Delta/Serrate/lag-2 (DSL) protein
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR026219 Jagged/Serrate protein
InterPro IPR011651 Notch ligand, N-terminal
InterPro IPR001007 von Willebrand factor, type C
Protein Ontology PR:000009194 protein jagged-2
References
(Earliest) J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54:113-145
(Latest) J:214133 Nantie LB, et al., Notch signaling in postnatal pituitary expansion: proliferation, progenitors, and cell specification. Mol Endocrinol. 2014 May;28(5):731-44
All references(145)
Other
accession IDs
MGD-MRK-14445, MGD-MRK-36557, MGD-MRK-39539, MGI:107977, MGI:109540, MGI:98321

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory