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Jag2
Gene Detail
 Symbol
Name
ID
Jag2
jagged 2
MGI:1098270
Synonyms D12Ggc2e, Serh
Feature Type protein coding gene
Genetic Map
Chromosome 12
61.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr12:112908590-112929495 bp, - strand
From NCBI annotation of GRCm38

  20906 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1677  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Jag2

Human
homologs
Human Homolog JAG2, jagged 2
NCBI Gene ID 3714
neXtProt AC  NX_Q9Y219
Human Synonyms  HJ2, SER2
Human Chr (Location)  14q32; chr14:105140981-105168824 (-)  GRCh38
Alleles
and
phenotypes
All alleles(6) : Spontaneous(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation die perinatally with craniofacial defects, fused digits, and increased numbers of sensory hair cells in the cochlea. Homozygotes for a spontaneous mutation exhibit fused digits and sometimes tail kinks.
 
Phenotype Images(1)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process auditory receptor cell fate commitment, cell communication, ...
Component integral component of membrane, integral component of plasma membrane, ...
Function calcium ion binding, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (91 records)
Data Summary: Results (242)    Tissues (106)    Images (57)
Theiler Stages: 1, 2, 3, 4, 5, 15, 17, 18, 19, 20, 21, 23, 24, 25, 28
Assay TypeResults
RNA in situ 187
RT-PCR 55
cDNA source data(59)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(78) Genomic(8) cDNA(61) Primer pair(5) Other(4)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000002799 (Evidence)
Entrez Gene16450 (Evidence)
UniGene186146
DFCITC1579775, TC1599124
DoTSDT.526069, DT.55150677
NIA Mouse Gene IndexU034394
Consensus CDS ProjectCCDS26200.1
International Mouse Knockout Project StatusJag2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16450 NCBI Gene Model | MGI Sequence Detail 20906 C57BL/6J ±  kb
transcript NM_010588 RefSeq | MGI Sequence Detail 4054 Not Specified 
polypeptide Q9QYE5 UniProt | EBI | MGI Sequence Detail 1247 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(9) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(159 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001774 Delta/Serrate/lag-2 (DSL) protein
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR026219 Jagged/Serrate protein
InterPro IPR011651 Notch ligand, N-terminal
InterPro IPR001007 von Willebrand factor, type C
Protein Ontology PR:000009194 protein jagged-2
Graphical View of Protein Domain Structure
References (Earliest) J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54:113-145
(Latest) J:202978 Yao Y, et al., Reducing Jagged 1 and 2 levels prevents cerebral arteriovenous malformations in matrix Gla protein deficiency. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):19071-6
All references(142)
Other
accession IDs
MGD-MRK-14445, MGD-MRK-36557, MGD-MRK-39539, MGI:107977, MGI:109540, MGI:98321

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory