About   Help   FAQ
Dll3 Gene Detail
Summary
  • Symbol
    Dll3
  • Name
    delta like canonical Notch ligand 3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096877
    NCBI Gene: 13389
  • Gene Overview
    MyGene.info: DLL3
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:28293555-28301785 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 16.67 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    26 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096877
protein coding gene Chr7:28293553-28302238 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031937
protein coding gene Chr7:27073241-27082803 (-)
A/J MGP_AJ_G0031916
protein coding gene Chr7:26414420-26423532 (-)
AKR/J MGP_AKRJ_G0031847
protein coding gene Chr7:27089381-27097819 (-)
BALB/cJ MGP_BALBcJ_G0031922
protein coding gene Chr7:26575340-26584005 (-)
C3H/HeJ MGP_C3HHeJ_G0031644
protein coding gene Chr7:27465917-27474552 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032387
protein coding gene Chr7:27939217-27951580 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029439
protein coding gene Chr7:27491486-27499256 (-)
CAST/EiJ MGP_CASTEiJ_G0030979
protein coding gene Chr7:20766207-20774934 (-)
CBA/J MGP_CBAJ_G0031607
protein coding gene Chr7:29192838-29201558 (-)
DBA/2J MGP_DBA2J_G0031760
protein coding gene Chr7:26178268-26186961 (-)
FVB/NJ MGP_FVBNJ_G0031717
protein coding gene Chr7:26246445-26255351 (-)
LP/J MGP_LPJ_G0031841
protein coding gene Chr7:27395004-27403718 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031752
protein coding gene Chr7:28702019-28710740 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032417
protein coding gene Chr7:26575077-26583989 (-)
PWK/PhJ MGP_PWKPhJ_G0030702
protein coding gene Chr7:21179085-21187954 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030537
protein coding gene Chr7:17579266-17587884 (-)
WSB/EiJ MGP_WSBEiJ_G0031086
protein coding gene Chr7:26903715-26913350 (-)



Homology
more
  • Human Ortholog
    DLL3, delta like canonical Notch ligand 3
  • Vertebrate Orthologs
    7
  • Human Ortholog
    DLL3, delta like canonical Notch ligand 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SCDO1
  • Links
    NCBI Gene ID: 10683
    neXtProt AC: NX_Q9NYJ7
    UniProt: Q9NYJ7

  • Chr Location
    19q13.2; chr19:39498917-39508481 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Dll3 mouse models; 1 with human DLL3 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    58 phenotypes from 6 alleles in 8 genetic backgrounds
    1 images
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit postnatal lethality, a shortened body and tail, delayed and abnormal somite formation, a kinked neural tube, disorganized PNS elements, and severe axial skeletal dysplasia, including disorganized vertebrae and ribs defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13389 NCBI Gene Model | MGI Sequence Detail 8231 C57BL/6J ±  kb
    transcript NM_007866 RefSeq | MGI Sequence Detail 2163 C57BL/6  
    polypeptide O88516 UniProt | EBI | MGI Sequence Detail 592 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      Genomic 4
      cDNA 17
      Primer pair 7
      Other 9

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13690, MGI:97819
    References
    more
    • Summaries
      All 136
      Developmental Gene Expression 97
      Diseases 1
      Gene Ontology 9
      Phenotypes 28
    • Earliest
      J:245 Dunn LC, et al., Stub, a new mutation in the mouse with marked effects on the spinal column. J Hered. 1942;33:235-9
    • Latest
      J:251433 Ha T, et al., The Retinal Pigment Epithelium Is a Notch Signaling Niche in the Mouse Retina. Cell Rep. 2017 Apr 11;19(2):351-363

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory