About   Help   FAQ
Dll3 Gene Detail
Summary
  • Symbol
    Dll3
  • Name
    delta-like 3 (Drosophila)
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096877
    NCBI Gene: 13389
  • Gene Overview
    MyGene.info: DLL3
Location & Maps
more
  • Sequence Map
    Chr7:28293553-28302238 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8686 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 16.67 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    DLL3, delta like canonical Notch ligand 3
  • Vertebrate Orthologs
    7
  • Human Ortholog
    DLL3, delta like canonical Notch ligand 3
    Orthology source: HomoloGene
  • Synonyms
    SCDO1
  • Links
    NCBI Gene ID: 10683
    neXtProt AC: NX_Q9NYJ7

  • Chr Location
    19q13; chr19:39498917-39508481 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Dll3 mouse models; 1 with human DLL3 associations

Human Disease Mouse Models
       Spondylocostal Dysostosis 1, Autosomal Recessive; SCDO1   OMIM: 277300 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    58 phenotypes from 6 alleles in 8 genetic backgrounds
    1 images
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    12
  • Gene trapped
    1
  • Radiation induced
    1
  • Spontaneous
    3
  • Targeted
    6
  • Transgenic
    1
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022517 VEGA Gene Model | MGI Sequence Detail 8686 C57BL/6J ±  kb
transcript OTTMUST00000053925 VEGA | MGI Sequence Detail 2618 Not Applicable  
polypeptide OTTMUSP00000025674 VEGA | MGI Sequence Detail 585 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    28 from dbSNP Build 142
  • PCR
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000006524 delta-like protein 3
  • InterPro Domains
    IPR001881 EGF-like calcium-binding domain
    IPR013032 EGF-like, conserved site
    IPR000742 EGF-like domain
    IPR009030 Growth factor receptor cysteine-rich domain
Molecular
Reagents
less
  • All nucleic 34
    Genomic 4
    cDNA 15
    Primer pair 7
    Other 8

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-13690, MGI:97819
References
more
  • Summaries
    All 128
    Developmental Gene Expression 91
    Diseases 1
    Gene Ontology 9
    Phenotypes 27
  • Earliest
    J:245 Dunn LC, et al., Stub, a new mutation in the mouse with marked effects on the spinal column. J Hered. 1942;33:235-9
  • Latest
    J:231601 de Melo J, et al., Lhx2 Is an Essential Factor for Retinal Gliogenesis and Notch Signaling. J Neurosci. 2016 Feb 24;36(8):2391-405

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/23/2016
MGI 6.05
The Jackson Laboratory