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Dll3
Gene Detail
Symbol

Name
ID
Dll3
delta-like 3 (Drosophila)
MGI:1096877
Feature Type
protein coding gene
Genetic Map
Chromosome 7
16.67 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:28293553-28302238 bp, - strand
From VEGA annotation of GRCm38

  8686 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7291  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: DLL3
Gene Tree: Dll3

Human
homologs
DLL3, delta-like 3 (Drosophila)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 10683
neXtProt AC: NX_Q9NYJ7

Human Synonyms: SCDO1

Human Chr (Location): 19q13; chr19:39498917-39508481 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human DLL3

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(1) Radiation induced(1) Spontaneous(2) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutants have shortened tail and trunk, with disorganized vertebrae and costal defects resulting from defective segmentation in the embryo and delayed and irregular somite formation.
 
Human Diseases Modeled in Mice Using Dll3 (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(1)
Interactions
Dll3 interacts with 58 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process cell differentiation, cell fate determination, ...
Component integral component of membrane, membrane
Function Notch binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (87 records)
Data Summary: Results (210)    Tissues (103)    Images (96)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 195
Northern blot 4
RT-PCR 11
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(34) Genomic(4) cDNA(15) Primer pair(7) Other(8)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000022517 (Evidence)
Ensembl Gene Model ENSMUSG00000003436 (Evidence)
Entrez Gene 13389 (Evidence)
Consensus CDS Project CCDS39856.1
International Mouse Phenotyping Consortium Status Dll3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022517 VEGA Gene Model | MGI Sequence Detail 8686 C57BL/6J ±  kb
transcript OTTMUST00000053925 VEGA | MGI Sequence Detail 2618 Not Applicable 
polypeptide OTTMUSP00000025674 VEGA | MGI Sequence Detail 585 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(2)
Polymorphisms
PCR(1) : SNPs within 2kb(28 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 EGF-like domain
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR011651 Notch ligand, N-terminal domain
Protein Ontology PR:000006524 delta-like protein 3
References
(Earliest) J:245 Dunn LC, et al., Stub, a new mutation in the mouse with marked effects on the spinal column. J Hered. 1942;33:235-9
(Latest) J:220460 Andre P, et al., Wnt5a and Wnt11 regulate mammalian anterior-posterior axis elongation. Development. 2015 Apr 15;142(8):1516-27
All references(123)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-13690, MGI:97819

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory