Dll3
Gene Detail

Symbol Name ID

Dll3 delta-like 3 (Drosophila) MGI:1096877

Feature Type

protein coding gene

Genetic Map

Chromosome 7

16.67 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr7:28293553-28302238 bp, - strand From VEGA annotation of GRCm38   8686 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7291  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Dll3

Human homologs

Human Homolog		DLL3, delta-like 3 (Drosophila)
NCBI Gene ID		10683
neXtProt AC		NX_Q9NYJ7
Human Synonyms		SCDO1
Human Chr (Location)		19q13; chr19:39989557-39999121 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human DLL3

Alleles and phenotypes

All alleles(10) : Targeted(6) Gene trapped(1) Spontaneous(2) Radiation induced(1)
 

Homozygous mutants have shortened tail and trunk, with disorganized vertebrae and costal defects resulting from defective segmentation in the embryo and delayed and irregular somite formation.

 
Human Diseases Modeled Using Mouse Dll3 (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	cell differentiation, cell fate determination, ...
Component	integral to membrane, membrane
Function	Notch binding, protein binding

External Resources: FuncBase

Expression

Literature Summary: (80 records)
Data Summary: Results (194)    Tissues (93)    Images (80)
Theiler Stages: 1, 4, 5, 8, 9, 10, 11, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 28

Assay Type	Results
RNA in situ	177
Northern blot	4
RT-PCR	13

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(33) Genomic(4) cDNA(15) Primer pair(7) Other(7)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000022517 (Evidence)
Ensembl Gene Model	ENSMUSG00000003436 (Evidence)
Entrez Gene	13389 (Evidence)
Consensus CDS Project	CCDS39856.1
International Mouse Knockout Project Status	Dll3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022517	VEGA Gene Model | MGI Sequence Detail	8686	C57BL/6J
transcript	OTTMUST00000053925	VEGA | MGI Sequence Detail	2618	Not Applicable
polypeptide	OTTMUSP00000025674	VEGA | MGI Sequence Detail	585	Not Applicable

All sequences(21) RefSeq(2) UniProt(2)

Polymorphisms

PCR(1) : SNPs(15 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR011651	Notch ligand, N-terminal
Protein Ontology	PR:000006524	delta-like protein 3

References

(Earliest) J:245 Dunn LC, et al., Stub, a new mutation in the mouse with marked effects on the spinal column. J Hered. 1942;33:235-9
(Latest) J:188254 Budry L, et al., The selector gene Pax7 dictates alternate pituitary cell fates through its pioneer action on chromatin remodeling. Genes Dev. 2012 Oct 15;26(20):2299-310
All references(118)

Other accession IDs

MGD-MRK-13690, MGI:97819