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Rax Gene Detail
Summary
  • Symbol
    Rax
  • Name
    retina and anterior neural fold homeobox
  • Synonyms
    E130303K03Rik, ey1, Rx
  • Feature Type
    protein coding gene
  • IDs
    MGI:109632
    NCBI Gene: 19434
  • Gene Overview
    MyGene.info: RAX
Location & Maps
more
  • Sequence Map
    Chr18:65934639-65939089 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4451 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 39.03 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    RAX, retina and anterior neural fold homeobox
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RAX, retina and anterior neural fold homeobox
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MCOP3, RX
  • Links
    NCBI Gene ID: 30062
    neXtProt AC: NX_Q9Y2V3

  • Chr Location
    18q21.32; chr18:59267035-59273393 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 8383
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: RAX
  • Gene Tree
    Rax
Human Diseases
more
  • Diseases
    1 with human RAX associations

Human Disease Mouse Models
       Microphthalmia, Isolated 3; MCOP3   OMIM: 611038
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    27 phenotypes from 7 alleles in 7 genetic backgrounds
    1 phenotype from multigenic genotypes
    48 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Gene trapped
    1
  • Spontaneous
    1
  • Targeted
    8
Homozygous null mutants die neonatally with severe brain defects including absence of forebrain/midbrain structures and fail to form eye structures. Homozygous hypomorph mutants are viable, but lack eyes and optic tracts and have hypothalamic defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 19434 NCBI Gene Model | MGI Sequence Detail 4451 C57BL/6J ±  kb
transcript NM_013833 RefSeq | MGI Sequence Detail 1687 Not Specified  
polypeptide O35602 UniProt | EBI | MGI Sequence Detail 342 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    33 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 26
    cDNA 18
    Primer pair 4
    Other 4

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-39631, MGD-MRK-9688, MGD-MRK-9690, MGI:2442635, MGI:95470
References
more
  • Summaries
    All 129
    Developmental Gene Expression 66
    Gene Ontology 10
    Phenotypes 48
  • Earliest
    J:229 Chase HB, Studies on an Anophthalmic Strain of Mice. IV. a Second Major Gene for Anophthalmia. Genetics. 1944 May;29(3):264-9
  • Latest
    J:231601 de Melo J, et al., Lhx2 Is an Essential Factor for Retinal Gliogenesis and Notch Signaling. J Neurosci. 2016 Feb 24;36(8):2391-405

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory