Rax
Gene Detail

Symbol Name ID

Rax retina and anterior neural fold homeobox MGI:109632

Synonyms

E130303K03Rik, ey1, Rx

Feature Type

protein coding gene

Genetic Map

Chromosome 18

39.03 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr18:65934639-65939089 bp, - strand From NCBI annotation of GRCm38   4451 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8383  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Gene Tree: Rax

Human homologs

Human Homolog		RAX, retina and anterior neural fold homeobox
NCBI Gene ID		30062
neXtProt AC		NX_Q9Y2V3
Human Synonyms		MCOP3, RX
Human Chr (Location)		18q21.32; chr18:56934267-56940625 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human RAX

Alleles and phenotypes

All alleles(8) : Targeted(6) Gene trapped(1) Spontaneous(1)
 

Homozygous null mutants die neonatally with severe brain defects including absence of forebrain/midbrain structures and fail to form eye structures. Homozygous hypomorph mutants are viable, but lack eyes and optic tracts and have hypothalamic defects.

 

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	brain development, camera-type eye development, ...
Component	nucleus
Function	DNA binding, sequence-specific DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (55 records)
Data Summary: Results (397)    Tissues (244)    Images (109)
Theiler Stages: 2, 3, 4, 5, 9, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	363
Northern blot	10
RT-PCR	24

cDNA source data(17)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(26) cDNA(18) Primer pair(4) Other(4)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000024518 (Evidence)
Entrez Gene	19434 (Evidence)
UniGene	431047
DFCI	TC1596649, TC1598514, TC1617665, TC1620174
DoTS	DT.40176024, DT.91564888, DT.94143027
NIA Mouse Gene Index	U038504
Consensus CDS Project	CCDS29311.1
International Mouse Knockout Project Status	Rax

Sequences

Length	Strain/Species
genomic	19434	NCBI Gene Model | MGI Sequence Detail	4451	C57BL/6J
transcript	NM_013833	RefSeq | MGI Sequence Detail	1687	Not Specified
polypeptide	O35602	UniProt | EBI | MGI Sequence Detail	342	Not Applicable

All sequences(24) RefSeq(2) UniProt(1)

Polymorphisms

All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs(22 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR003654	OAR domain
Protein Ontology	PR:000013771	retinal homeobox protein Rx

Graphical View of Protein Domain Structure

References

(Earliest) J:229 Chase HB, Studies on an Anophthalmic Strain of Mice. IV. a Second Major Gene for Anophthalmia. Genetics. 1944 May;29(3):264-9
(Latest) J:193919 Lu F, et al., Rax is a selector gene for mediobasal hypothalamic cell types. J Neurosci. 2013 Jan 2;33(1):259-72
All references(118)

Other accession IDs

MGD-MRK-39631, MGD-MRK-9688, MGD-MRK-9690, MGI:2442635, MGI:95470