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Rax
Gene Detail
 Symbol
Name
ID
Rax
retina and anterior neural fold homeobox
MGI:109632
Synonyms E130303K03Rik, ey1, Rx
Feature Type protein coding gene
Genetic Map
Chromosome 18
39.03 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr18:65934639-65939089 bp, - strand
From NCBI annotation of GRCm38

  4451 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8383  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Gene Tree: Rax

Human
homologs
Human Homolog RAX, retina and anterior neural fold homeobox
NCBI Gene ID 30062
neXtProt AC  NX_Q9Y2V3
Human Synonyms  MCOP3, RX
Human Chr (Location)  18q21.32; chr18:59267035-59273393 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human RAX
Alleles
and
phenotypes
All alleles(9) : Targeted(7) Gene trapped(1) Spontaneous(1)
 
Homozygous null mutants die neonatally with severe brain defects including absence of forebrain/midbrain structures and fail to form eye structures. Homozygous hypomorph mutants are viable, but lack eyes and optic tracts and have hypothalamic defects.
 
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process brain development, camera-type eye development, ...
Component nucleus
Function DNA binding, sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (60 records)
Data Summary: Results (397)    Tissues (245)    Images (109)
Theiler Stages: 2, 3, 4, 5, 9, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 363
Northern blot 10
RT-PCR 24
cDNA source data(17)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(26) cDNA(18) Primer pair(4) Other(4)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000024518 (Evidence)
Entrez Gene19434 (Evidence)
UniGene431047
DFCITC1596649, TC1598514, TC1617665, TC1620174
DoTSDT.40176024, DT.91564888, DT.94143027
NIA Mouse Gene IndexU038504
Consensus CDS ProjectCCDS29311.1
International Mouse Knockout Project StatusRax
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 19434 NCBI Gene Model | MGI Sequence Detail 4451 C57BL/6J ±  kb
transcript NM_013833 RefSeq | MGI Sequence Detail 1687 Not Specified 
polypeptide O35602 UniProt | EBI | MGI Sequence Detail 342 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(1)
Polymorphisms All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(33 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR003654 OAR domain
Protein Ontology PR:000013771 retinal homeobox protein Rx
Graphical View of Protein Domain Structure
References (Earliest) J:229 Chase HB, Studies on an Anophthalmic Strain of Mice. IV. a Second Major Gene for Anophthalmia. Genetics. 1944 May;29(3):264-9
(Latest) J:199290 Aujla PK, et al., Notch/Rbpjkappa signaling regulates progenitor maintenance and differentiation of hypothalamic arcuate neurons. Development. 2013 Sep;140(17):3511-21
All references(124)
Other
accession IDs
MGD-MRK-39631, MGD-MRK-9688, MGD-MRK-9690, MGI:2442635, MGI:95470

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory