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Rax Gene Detail
Summary
  • Symbol
    Rax
  • Name
    retina and anterior neural fold homeobox
  • Synonyms
    E130303K03Rik, ey1, Rx
  • Feature Type
    protein coding gene
  • IDs
    MGI:109632
    NCBI Gene: 19434
  • Gene Overview
    MyGene.info: RAX
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:65934639-65939089 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 39.03 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    33 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109632
protein coding gene Chr18:65934639-65939089 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024513
protein coding gene Chr18:66123451-66127902 (-)
A/J MGP_AJ_G0024480
protein coding gene Chr18:63233283-63237734 (-)
AKR/J MGP_AKRJ_G0024450
protein coding gene Chr18:65019568-65024019 (-)
BALB/cJ MGP_BALBcJ_G0024479
protein coding gene Chr18:63375501-63379952 (-)
C3H/HeJ MGP_C3HHeJ_G0024247
protein coding gene Chr18:65232919-65237370 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024926
protein coding gene Chr18:67874939-67879389 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022357
protein coding gene Chr18:62676014-62680428 (-)
CAST/EiJ MGP_CASTEiJ_G0023720
protein coding gene Chr18:65232981-65237461 (-)
CBA/J MGP_CBAJ_G0024217
protein coding gene Chr18:70121265-70125716 (-)
DBA/2J MGP_DBA2J_G0024347
protein coding gene Chr18:62902268-62906719 (-)
FVB/NJ MGP_FVBNJ_G0024313
protein coding gene Chr18:62278781-62283231 (-)
LP/J MGP_LPJ_G0024431
protein coding gene Chr18:65969538-65973989 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024342
protein coding gene Chr18:71511196-71515646 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024973
protein coding gene Chr18:65234400-65238850 (-)
PWK/PhJ MGP_PWKPhJ_G0023463
protein coding gene Chr18:63155529-63159982 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023268
protein coding gene Chr18:65393595-65398047 (-)
WSB/EiJ MGP_WSBEiJ_G0023784
protein coding gene Chr18:65098201-65102651 (-)



Homology
more
  • Human Ortholog
    RAX, retina and anterior neural fold homeobox
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RAX, retina and anterior neural fold homeobox
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MCOP3, RX
  • Links
    NCBI Gene ID: 30062
    neXtProt AC: NX_Q9Y2V3
    UniProt: Q9Y2V3

  • Chr Location
    18q21.32; chr18:59267035-59273393 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 8383
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RAX
  • Gene Tree
    Rax
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 7 alleles in 7 genetic backgrounds
    1 phenotype from multigenic genotypes
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants die neonatally with severe brain defects including absence of forebrain/midbrain structures and fail to form eye structures. Homozygous hypomorph mutants are viable, but lack eyes and optic tracts and have hypothalamic defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19434 NCBI Gene Model | MGI Sequence Detail 4451 C57BL/6J ±  kb
    transcript NM_013833 RefSeq | MGI Sequence Detail 1687 Not Specified  
    polypeptide O35602 UniProt | EBI | MGI Sequence Detail 342 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 20
      Primer pair 5
      Other 7

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-39631, MGD-MRK-9688, MGD-MRK-9690, MGI:2442635, MGI:95470
    References
    more
    • Summaries
      All 144
      Developmental Gene Expression 74
      Gene Ontology 10
      Phenotypes 53
    • Earliest
      J:229 Chase HB, Studies on an Anophthalmic Strain of Mice. IV. a Second Major Gene for Anophthalmia. Genetics. 1944 May;29(3):264-9
    • Latest
      J:264207 Rodgers HM, et al., The role of the Rx homeobox gene in retinal progenitor proliferation and cell fate specification. Mech Dev. 2018 Jun;151:18-29

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory