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Aip Gene Detail
Summary
  • Symbol
    Aip
  • Name
    aryl-hydrocarbon receptor-interacting protein
  • Synonyms
    Ara9, D19Bwg1412e, Fkbp16, Xap2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109622
    NCBI Gene: 11632
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr19:4114446-4125858 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11413 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 3.82 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    AIP, aryl hydrocarbon receptor interacting protein
  • Vertebrate Orthologs
    11
  • Human Ortholog
    AIP, aryl hydrocarbon receptor interacting protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARA9, FKBP16, FKBP37, PITA1, SMTPHN, XAP2, XAP-2
  • Links
    NCBI Gene ID: 9049
    neXtProt AC: NX_O00170
    UniProt: O00170

  • Chr Location
    11q13.2; chr11:67483029-67491108 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2959
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: AIP
  • Gene Tree
    Aip
Human Diseases
more
  • Diseases
    3 with human AIP associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 3 alleles in 4 genetic backgrounds
    5 phenotypes from multigenic genotypes
    7 images
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in lethality from E10 to E19. Mice exhibit cardiac malformations such as double outlet right ventricle and ventricular septal defect and sometimes hemorrhage or petechiae. Mice homozygous for a hypomorphic allele exhibit patent ductus venosus.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000026281 VEGA Gene Model | MGI Sequence Detail 11413 C57BL/6J ±  kb
    transcript OTTMUST00000064993 VEGA | MGI Sequence Detail 1378 Not Applicable  
    polypeptide OTTMUSP00000032334 VEGA | MGI Sequence Detail 330 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      29 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000003875 AH receptor-interacting protein
    • InterPro Domains
      IPR031208 AH receptor-interacting protein
      IPR001179 FKBP-type peptidyl-prolyl cis-trans isomerase domain
      IPR011990 Tetratricopeptide-like helical domain superfamily
      IPR019734 Tetratricopeptide repeat
      IPR013026 Tetratricopeptide repeat-containing domain
    Molecular
    Reagents
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    • All nucleic 92
      cDNA 91
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-33944, MGD-MRK-39621, MGI:106252, MGI:2147439, MGI:2147730
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 4
      Gene Ontology 9
      Phenotypes 14
    • Earliest
      J:39465 Ma Q, et al., A novel cytoplasmic protein that interacts with the Ah receptor, contains tetratricopeptide repeat motifs, and augments the transcriptional response to 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Biol Chem. 1997 Apr 4;272(14):8878-84
    • Latest
      J:250909 Fukuda T, et al., Augmented Growth Hormone Secretion and Stat3 Phosphorylation in an Aryl Hydrocarbon Receptor Interacting Protein (AIP)-Disrupted Somatotroph Cell Line. PLoS One. 2016;11(10):e0164131

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory