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Aip
Gene Detail
 Symbol
Name
ID
Aip
aryl-hydrocarbon receptor-interacting protein
MGI:109622
Synonyms Ara9, D19Bwg1412e, Fkbp16, Xap2
Feature Type protein coding gene
Genetic Map
Chromosome 19
3.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr19:4114446-4125858 bp, - strand
From VEGA annotation of GRCm38

  11413 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2959  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Aip

Human
homologs
Human Homolog AIP, aryl hydrocarbon receptor interacting protein
NCBI Gene ID 9049
neXtProt AC  NX_O00170
Human Synonyms  ARA9, FKBP16, FKBP37, SMTPHN, XAP2, XAP-2
Human Chr (Location)  11q13.3; chr11:67483034-67491108 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human AIP
Mutations,
alleles, and
phenotypes
All mutations/alleles(26) : Gene trapped(19) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in lethality from E10 to E19. Mice exhibit cardiac malformations such as double outlet right ventricle and ventricular septal defect and sometimes hemorrhage or petechiae. Mice homozygous for a hypomorphic allele exhibit patent ductus venosus.
 
Phenotype Images(7)
Interactions
Aip interacts with 65 markers (Mir124a-1, Mir124a-2, Mir124a-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process negative regulation of cyclic-nucleotide phosphodiesterase activity, protein folding, ...
Component cytoplasm, cytosol, ...
Function GAF domain binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (54)    Tissues (52)    Images (6)
Theiler Stages: 17, 18, 21, 23, 28
Assay TypeResults
RNA in situ 54
cDNA source data(90)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(91) cDNA(90) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000026281 (Evidence)
Ensembl Gene ModelENSMUSG00000024847 (Evidence)
Entrez Gene11632 (Evidence)
UniGene10433
DFCITC1574952
DoTSDT.101265574, DT.101389095, DT.94339039, DT.94339118
NIA Mouse Gene IndexU019102
Consensus CDS ProjectCCDS29415.1
International Mouse Knockout Project StatusAip
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026281 VEGA Gene Model | MGI Sequence Detail 11413 C57BL/6J ±  kb
transcript OTTMUST00000064993 VEGA | MGI Sequence Detail 1378 Not Applicable 
polypeptide OTTMUSP00000032334 VEGA | MGI Sequence Detail 330 Not Applicable 

For the selected sequences
All sequences(55) RefSeq(16) UniProt(2)
Polymorphisms SNPs within 2kb(29 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001179 Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain
InterPro IPR011990 Tetratricopeptide-like helical
InterPro IPR019734 Tetratricopeptide repeat
InterPro IPR013026 Tetratricopeptide repeat-containing domain
Protein Ontology PR:000003875 AH receptor-interacting protein
References (Earliest) J:39465 Ma Q, et al., A novel cytoplasmic protein that interacts with the Ah receptor, contains tetratricopeptide repeat motifs, and augments the transcriptional response to 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Biol Chem. 1997 Apr 4;272(14):8878-84
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(50)
Other
accession IDs
MGD-MRK-33944, MGD-MRK-39621, MGI:106252, MGI:2147439, MGI:2147730

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory