Aip
Gene Detail

Symbol Name ID

Aip aryl-hydrocarbon receptor-interacting protein MGI:109622

Synonyms

Ara9, D19Bwg1412e, Fkbp16, Xap2

Feature Type

protein coding gene

Genetic Map

Chromosome 19

3.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr19:4114446-4125858 bp, - strand From VEGA annotation of GRCm38   11413 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2959  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Aip

Human homologs

Human Homolog		AIP, aryl hydrocarbon receptor interacting protein
NCBI Gene ID		9049
neXtProt AC		NX_O00170
Human Synonyms		ARA9, FKBP16, FKBP37, SMTPHN, XAP2, XAP-2
Human Chr (Location)		11q13.3; chr11:67250505-67258579 (+)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human AIP

Alleles and phenotypes

All alleles(26) : Targeted(7) Gene trapped(19)
 

Homozygous mutation of this gene results in lethality from E10 to E19. Mice exhibit cardiac malformations such as double outlet right ventricle and ventricular septal defect and sometimes hemorrhage or petechiae. Mice homozygous for a hypomorphic allele exhibit patent ductus venosus.

 
Phenotype Images(5)

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	negative regulation of cyclic-nucleotide phosphodiesterase activity, protein folding, ...
Component	cytoplasm, cytosol, ...
Function	GAF domain binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (54)    Tissues (52)    Images (6)
Theiler Stages: 17, 18, 21, 23, 28

Assay Type	Results
RNA in situ	54

cDNA source data(94)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(95) cDNA(94) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000026281 (Evidence)
Ensembl Gene Model	ENSMUSG00000024847 (Evidence)
Entrez Gene	11632 (Evidence)
UniGene	10433
DFCI	TC1574952
DoTS	DT.101265574, DT.101389095, DT.94339039, DT.94339118
NIA Mouse Gene Index	U019102
Consensus CDS Project	CCDS29415.1
International Mouse Knockout Project Status	Aip

Sequences

Length	Strain/Species
genomic	OTTMUSG00000026281	VEGA Gene Model | MGI Sequence Detail	11413	C57BL/6J
transcript	OTTMUST00000064993	VEGA | MGI Sequence Detail	1378	Not Applicable
polypeptide	OTTMUSP00000032334	VEGA | MGI Sequence Detail	330	Not Applicable

All sequences(43) RefSeq(4) UniProt(2)

Polymorphisms

SNPs(28 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001179	Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain
InterPro	IPR011990	Tetratricopeptide-like helical
InterPro	IPR019734	Tetratricopeptide repeat
InterPro	IPR013026	Tetratricopeptide repeat-containing domain
Protein Ontology	PR:000003875	AH receptor-interacting protein

References

(Earliest) J:39465 Ma Q, et al., A novel cytoplasmic protein that interacts with the Ah receptor, contains tetratricopeptide repeat motifs, and augments the transcriptional response to 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Biol Chem. 1997 Apr 4;272(14):8878-84
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(48)

Other accession IDs

MGD-MRK-33944, MGD-MRK-39621, MGI:106252, MGI:2147439, MGI:2147730