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Arvcf
Gene Detail
Symbol

Name
ID
Arvcf
armadillo repeat gene deleted in velo-cardio-facial syndrome
MGI:109620
Feature Type
protein coding gene
Genetic Map
Chromosome 16
11.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr16:18348182-18407076 bp, + strand
From VEGA annotation of GRCm38

  58895 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31046  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Arvcf

Human
homologs
Human Homolog ARVCF, armadillo repeat gene deleted in velocardiofacial syndrome
NCBI Gene ID 421
neXtProt AC  NX_O00192
Human Chr (Location)  22q11.21; chr22:19966603-20016802 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(72) : Gene trapped(64) Targeted(8)
Genomic Mutations involving Arvcf (4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted allele display abnormal gait and cataracts.
 
Alleles Annotated to Human Diseases(2)   
Interactions
Arvcf interacts with 226 markers (Mir15a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules, cell adhesion, ...
Component cell junction, cytoplasm, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (81)    Tissues (52)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 49
RT-PCR 32
cDNA source data(83)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(110) Genomic(24) cDNA(84) Primer pair(1) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000026041 (Evidence)
Ensembl Gene ModelENSMUSG00000000325 (Evidence)
Entrez Gene11877 (Evidence)
UniGene293599
DFCITC1628147, TC1574523, TC1602208, TC1674535, TC1594078, TC1590650
Consensus CDS ProjectCCDS28020.1, CCDS70693.1, CCDS70694.1
International Mouse Knockout Project StatusArvcf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026041 VEGA Gene Model | MGI Sequence Detail 58895 C57BL/6J ±  kb
transcript OTTMUST00000064282 VEGA | MGI Sequence Detail 4800 Not Applicable 
polypeptide OTTMUSP00000031897 VEGA | MGI Sequence Detail 962 Not Applicable 

For the selected sequences
All sequences(95) RefSeq(26) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(163 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000225 Armadillo
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
Protein Ontology PR:000004333 armadillo repeat protein deleted in velo-cardio-facial syndrome
References
(Earliest) J:39493 Sirotkin H, et al., Identification of a new human catenin gene family member (ARVCF) from the region deleted in velo-cardio-facial syndrome. Genomics. 1997 Apr 1;41(1):75-83
(Latest) J:191130 Maynard TM, et al., 22q11 Gene dosage establishes an adaptive range for sonic hedgehog and retinoic acid signaling during early development. Hum Mol Genet. 2013 Jan 15;22(2):300-12
All references(44)
Other
accession IDs
MGD-MRK-39619

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory