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Arvcf
Gene Detail
Symbol

Name
ID
Arvcf
armadillo repeat gene deleted in velo-cardio-facial syndrome
MGI:109620
Feature Type
protein coding gene
Genetic Map
Chromosome 16
11.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr16:18348182-18407076 bp, + strand
From VEGA annotation of GRCm38

  58895 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31046  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ARVCF
Gene Tree: Arvcf

Human
homologs
ARVCF, armadillo repeat gene deleted in velocardiofacial syndrome
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 421
neXtProt AC: NX_O00192

Human Chr (Location): 22q11.21; chr22:19966603-20016802 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(78) : Gene trapped(64) Targeted(13) Transgenic(1)
Genomic Mutations involving Arvcf (9)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a targeted allele display abnormal gait and cataracts.
 
Mutations Annotated to Human Diseases (3)   
Interactions
Arvcf interacts with 225 markers (Mir15a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules, cell adhesion, ...
Component cell junction, cytoplasm, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (81)    Tissues (52)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 49
RT-PCR 32
cDNA source data(83)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase arvcf ; ZFIN arvcfb    NEW 
Molecular
reagents
All nucleic(110) Genomic(24) cDNA(84) Primer pair(1) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000026041 (Evidence)
Ensembl Gene Model ENSMUSG00000000325 (Evidence)
Entrez Gene 11877 (Evidence)
UniGene 293599
DFCI TC1574523, TC1594078, TC1590650, TC1602208, TC1674535, TC1628147
Consensus CDS Project CCDS28020.1, CCDS70693.1, CCDS70694.1
International Mouse Phenotyping Consortium Status Arvcf
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026041 VEGA Gene Model | MGI Sequence Detail 58895 C57BL/6J ±  kb
transcript OTTMUST00000064282 VEGA | MGI Sequence Detail 4800 Not Applicable 
polypeptide OTTMUSP00000031897 VEGA | MGI Sequence Detail 962 Not Applicable 

For the selected sequences
All sequences(91) RefSeq(24) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(163 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000225 Armadillo
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
Protein Ontology PR:000004333 armadillo repeat protein deleted in velo-cardio-facial syndrome
References
(Earliest) J:39493 Sirotkin H, et al., Identification of a new human catenin gene family member (ARVCF) from the region deleted in velo-cardio-facial syndrome. Genomics. 1997 Apr 1;41(1):75-83
(Latest) J:219824 Hendley AM, et al., p120 Catenin is required for normal tubulogenesis but not epithelial integrity in developing mouse pancreas. Dev Biol. 2015 Mar 1;399(1):41-53
All references(45)
Other
accession IDs
MGD-MRK-39619

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory