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Jag1
Gene Detail
Symbol

Name
ID
Jag1
jagged 1
MGI:1095416
Synonyms
ABE2, Gsfabe2, Headturner, Htu, Ozz, Serrate-1
Feature Type
protein coding gene
Genetic Map
Chromosome 2
67.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr2:137081456-137116644 bp, - strand
From VEGA annotation of GRCm38

  35189 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:180  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: JAG1
Gene Tree: Jag1

Human
homologs
JAG1, jagged 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 182
neXtProt AC: NX_P78504

Human Synonyms: AGS, AHD, AWS, CD339, HJ1, JAGL1

Human Chr (Location): 20p12.1-p11.23; chr20:10637684-10674046 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human JAG1

Mutations,
alleles, and
phenotypes
All mutations/alleles(27) : Chemically induced (ENU)(6) Gene trapped(12) Radiation induced(1) Targeted(8)
Genomic Mutations involving Jag1 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mutants exhibit extensive hemorrhaging and die prior to embryonic day 11.5, while heterozygotes exhibit defects of the eye. Heterozygotes for missense mutations have inner ear abnormalities. Other mutant mice display abnormal head movements.
 
Human Diseases Modeled in Mice Using Jag1 (2)    Mutations Annotated to Human Diseases (5)    Phenotype Images(4)
Interactions
Jag1 interacts with 349 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (51 annotations)
Process aorta morphogenesis, auditory receptor cell differentiation, ...
Component apical part of cell, integral component of membrane, ...
Function calcium ion binding, Notch binding, ...
External Resources: FuncBase
Expression
Literature Summary: (270 records)
Data Summary: Results (682)    Tissues (414)    Images (154)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 15
RNA in situ 600
Northern blot 11
RT-PCR 56
cDNA source data(52)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA JAG1 ; Xenbase jag1 ; ZFIN jag1a, jag1b    NEW 
Molecular
reagents
All nucleic(78) Genomic(1) cDNA(59) Primer pair(8) Other(10)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000015560 (Evidence)
Ensembl Gene Model ENSMUSG00000027276 (Evidence)
Entrez Gene 16449 (Evidence)
UniGene 22398
DFCI TC1578527
DoTS DT.527087, DT.529573
NIA Mouse Gene Index U023414
Consensus CDS Project CCDS16797.1
International Mouse Phenotyping Consortium Status Jag1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015560 VEGA Gene Model | MGI Sequence Detail 35189 C57BL/6J ±  kb
transcript OTTMUST00000036966 VEGA | MGI Sequence Detail 5612 Not Applicable 
polypeptide OTTMUSP00000016586 VEGA | MGI Sequence Detail 1218 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(4) UniProt(4)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(275 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001774 Delta/Serrate/lag-2 (DSL) protein
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR026219 Jagged/Serrate protein
InterPro IPR011651 Notch ligand, N-terminal
InterPro IPR001007 von Willebrand factor, type C
Protein Ontology PR:000001921 protein jagged-1
References
(Earliest) J:113824 Zimrin AB, et al., An antisense oligonucleotide to the notch ligand jagged enhances fibroblast growth factor-induced angiogenesis in vitro. J Biol Chem. 1996 Dec 20;271(51):32499-502
(Latest) J:221164 Di Giovanni V, et al., Fibroblast growth factor receptor-Frs2alpha signaling is critical for nephron progenitors. Dev Biol. 2015 Apr 1;400(1):82-93
All references(366)
Disease annotation references (7)
Other
accession IDs
MGI:1891333, MGI:2664252, MGI:3530800

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory