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Jag1
Gene Detail
 Symbol
Name
ID
Jag1
jagged 1
MGI:1095416
Synonyms ABE2, Gsfabe2, Headturner, Htu, Ozz, Serrate-1
Feature Type protein coding gene
Genetic Map
Chromosome 2
67.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr2:137081456-137116644 bp, - strand
From VEGA annotation of GRCm38

  35189 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:180  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Jag1

Human
homologs
Human Homolog JAG1, jagged 1
NCBI Gene ID 182
neXtProt AC  NX_P78504
Human Synonyms  AGS, AHD, AWS, CD339, HJ1, JAGL1
Human Chr (Location)  20p12.1-p11.23; chr20:10637684-10674046 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human JAG1
Alleles
and
phenotypes
All alleles(26) : Targeted(8) Gene trapped(12) Chemically induced(6)
 
Homozygous null mutants exhibit extensive hemorrhaging and die prior to embryonic day 11.5, while heterozygotes exhibit defects of the eye. Heterozygotes for missense mutations have inner ear abnormalities. Other mutant mice display abnormal head movements.
 
Human Diseases Modeled Using Mouse Jag1 (2)    Alleles Annotated to Human Diseases(4)    Phenotype Images(3)
Gene Ontology
(GO)
classifications
All GO classifications: (48 annotations)
Process aorta morphogenesis, auditory receptor cell differentiation, ...
Component apical part of cell, integral component of membrane, ...
Function calcium ion binding, Notch binding, ...
External Resources: FuncBase
Expression
Literature Summary: (247 records)
Data Summary: Results (673)    Tissues (405)    Images (153)
Theiler Stages: 1, 2, 3, 4, 5, 11, 12, 13, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 15
RNA in situ 589
Northern blot 11
RT-PCR 58
cDNA source data(52)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(76) Genomic(1) cDNA(58) Primer pair(8) Other(9)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000015560 (Evidence)
Ensembl Gene ModelENSMUSG00000027276 (Evidence)
Entrez Gene16449 (Evidence)
UniGene22398
DFCITC1578527
DoTSDT.527087, DT.529573
NIA Mouse Gene IndexU023414
Consensus CDS ProjectCCDS16797.1
International Mouse Knockout Project StatusJag1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015560 VEGA Gene Model | MGI Sequence Detail 35189 C57BL/6J ±  kb
transcript OTTMUST00000036966 VEGA | MGI Sequence Detail 5612 Not Applicable 
polypeptide OTTMUSP00000016586 VEGA | MGI Sequence Detail 1218 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(4)
Polymorphisms All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(275 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001774 Delta/Serrate/lag-2 (DSL) protein
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR026219 Jagged/Serrate protein
InterPro IPR011651 Notch ligand, N-terminal
InterPro IPR001007 von Willebrand factor, type C
Protein Ontology PR:000001921 protein jagged-1
References (Earliest) J:113824 Zimrin AB, et al., An antisense oligonucleotide to the notch ligand jagged enhances fibroblast growth factor-induced angiogenesis in vitro. J Biol Chem. 1996 Dec 20;271(51):32499-502
(Latest) J:205705 Liu H, et al., Regulation of dendritic cell differentiation in bone marrow during emergency myelopoiesis. J Immunol. 2013 Aug 15;191(4):1916-26
All references(333)
Other
accession IDs
MGI:1891333, MGI:2664252, MGI:3530800

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/15/2014
MGI 5.17
The Jackson Laboratory