Lfng
Gene Detail

Symbol Name ID

Lfng LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase MGI:1095413

Synonyms

lunatic fringe

Feature Type

protein coding gene

Genetic Map

Chromosome 5

79.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr5:140607341-140615543 bp, + strand From Ensembl annotation of GRCm38   8203 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:22475  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Protein SuperFamily: beta-1,3-N-acetylglucosaminyltransferase, radical fringe type
Gene Tree: Lfng

Human homologs

Human Homolog		LFNG, LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
NCBI Gene ID		3955
neXtProt AC		NX_Q8NES3
Human Synonyms		SCDO3
Human Chr (Location)		7p22.2; chr7:2552163-2568811 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human LFNG

Alleles and phenotypes

All alleles(10) : Targeted(8) Gene trapped(1) Chemically induced(1)
 

Mice homozygous for a knock-out allele exhibit a short tail and abnormal rib, somite, and lung development. Mice homozygous mice exhibit reduced female fertility, abnormal hair cells, and abnormal axial skeleton morphology.

 

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	compartment pattern specification, female meiosis, ...
Component	Golgi apparatus, integral to Golgi membrane, ...
Function	metal ion binding, O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (155 records)
Data Summary: Results (223)    Tissues (106)    Images (102)
Theiler Stages: 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	211
Northern blot	10
RT-PCR	2

cDNA source data(57)
External Resources: GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(69) cDNA(59) Primer pair(1) Other(9)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000029570 (Evidence)
Entrez Gene	16848 (Evidence)
UniGene	12834
DFCI	TC1583479, TC1602090
DoTS	DT.492479
NIA Mouse Gene Index	U006376
EC	2.4.1.222
Consensus CDS Project	CCDS19821.1
International Mouse Knockout Project Status	Lfng

Sequences

Length	Strain/Species
genomic	ENSMUSG00000029570	Ensembl Gene Model | MGI Sequence Detail	8203	C57BL/6J
transcript	ENSMUST00000031555	Ensembl | MGI Sequence Detail	2282	Not Applicable
polypeptide	ENSMUSP00000031555	Ensembl | MGI Sequence Detail	378	Not Applicable

All sequences(23) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(5 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017374	Fringe
InterPro	IPR003378	Fringe-like
Protein Ontology	PR:000009765	beta-1,3-N-acetylglucosaminyltransferase lunatic fringe

References

(Earliest) J:41128 Johnston SH, et al., A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway. Development. 1997 Jun;124(11):2245-54
(Latest) J:190545 Boulet AM, et al., Signaling by FGF4 and FGF8 is required for axial elongation of the mouse embryo. Dev Biol. 2012 Nov 15;371(2):235-45
All references(203)

Other accession IDs

MGI:2141150