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Lfng Gene Detail
Summary
  • Symbol
    Lfng
  • Name
    LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
  • Synonyms
    lunatic fringe
  • Feature Type
    protein coding gene
  • IDs
    MGI:1095413
    NCBI Gene: 16848
  • Gene Overview
    MyGene.info: LFNG
Location & Maps
more
  • Sequence Map
    Chr5:140607320-140615545 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      8226 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 79.15 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    LFNG, LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LFNG, LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SCDO3
  • Links
    NCBI Gene ID: 3955
    neXtProt AC: NX_Q8NES3

  • Chr Location
    7p22.2; chr7:2512529-2529177 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human LFNG associations

Human Disease Mouse Models
       Spondylocostal Dysostosis 3, Autosomal Recessive; SCDO3   OMIM: 609813
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    59 phenotypes from 6 alleles in 12 genetic backgrounds
    34 phenotypes from multigenic genotypes
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    14
  • Chemically induced (ENU)
    1
  • Gene trapped
    1
  • Targeted
    8
  • Transgenic
    4
  • Incidental Mutations
    APF
Mice homozygous for a knock-out allele exhibit a short tail and abnormal rib, somite, and lung development. Mice homozygous mice exhibit reduced female fertility, abnormal hair cells, and abnormal axial skeleton morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000054831 VEGA Gene Model | MGI Sequence Detail 8226 C57BL/6J ±  kb
transcript OTTMUST00000135862 VEGA | MGI Sequence Detail 2305 Not Applicable  
polypeptide OTTMUSP00000071822 VEGA | MGI Sequence Detail 378 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    10 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 75
    cDNA 59
    Primer pair 2
    Other 14

    Microarray probesets 5
Other
Accession IDs
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MGI:2141150
References
more
  • Summaries
    All 229
    Developmental Gene Expression 179
    Gene Ontology 11
    Phenotypes 40
  • Earliest
    J:41128 Johnston SH, et al., A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway. Development. 1997 Jun;124(11):2245-54
  • Latest
    J:228526 Marks M, et al., Analysis of the Fam181 gene family during mouse development reveals distinct strain-specific expression patterns, suggesting a role in nervous system development and function. Gene. 2016 Jan 10;575(2 Pt 2):438-51

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory