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Lfng
Gene Detail
Symbol

Name
ID
Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
MGI:1095413
Synonyms
lunatic fringe
Feature Type
protein coding gene
Genetic Map
Chromosome 5
79.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr5:140607341-140615543 bp, + strand
From Ensembl annotation of GRCm38

  8203 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22475  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: beta-1,3-N-acetylglucosaminyltransferase, radical fringe type
Gene Tree: Lfng

Human
homologs
Human Homolog LFNG, LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
NCBI Gene ID 3955
neXtProt AC  NX_Q8NES3
Human Synonyms  SCDO3
Human Chr (Location)  7p22.2; chr7:2512529-2529177 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human LFNG
Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(8)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit a short tail and abnormal rib, somite, and lung development. Mice homozygous mice exhibit reduced female fertility, abnormal hair cells, and abnormal axial skeleton morphology.
 
Interactions
Lfng interacts with 144 markers (Mir1a-2, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (163 records)
Data Summary: Results (241)    Tissues (109)    Images (114)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 229
Northern blot 10
RT-PCR 2
cDNA source data(57)
External Resources: GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(72) cDNA(59) Primer pair(1) Other(12)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000029570 (Evidence)
Entrez Gene16848 (Evidence)
UniGene12834
DFCITC1583479, TC1602090
DoTSDT.492479
NIA Mouse Gene IndexU006376
EC2.4.1.222
Consensus CDS ProjectCCDS19821.1
International Mouse Knockout Project StatusLfng
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029570 Ensembl Gene Model | MGI Sequence Detail 8203 C57BL/6J ±  kb
transcript ENSMUST00000031555 Ensembl | MGI Sequence Detail 2282 Not Applicable 
polypeptide ENSMUSP00000031555 Ensembl | MGI Sequence Detail 378 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(10 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017374 Fringe
InterPro IPR003378 Fringe-like
Protein Ontology PR:000009765 beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
References
(Earliest) J:41128 Johnston SH, et al., A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway. Development. 1997 Jun;124(11):2245-54
(Latest) J:208899 Williams DR, et al., Posterior skeletal development and the segmentation clock period are sensitive to Lfng dosage during somitogenesis. Dev Biol. 2014 Apr 15;388(2):159-69
All references(214)
Other
accession IDs
MGI:2141150

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory