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Lfng
Gene Detail
Symbol

Name
ID
Lfng
LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
MGI:1095413
Synonyms
lunatic fringe
Feature Type
protein coding gene
Genetic Map
Chromosome 5
79.15 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr5:140607341-140615543 bp, + strand
From Ensembl annotation of GRCm38

  8203 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22475  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LFNG
Protein SuperFamily: beta-1,3-N-acetylglucosaminyltransferase, radical fringe type
Gene Tree: Lfng

Human
homologs
LFNG, LFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 3955
neXtProt AC: NX_Q8NES3

Human Synonyms: SCDO3

Human Chr (Location): 7p22.2; chr7:2512529-2529177 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human LFNG

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Chemically induced (ENU)(1) Gene trapped(1) Targeted(8)
Incidental mutations (data from APF )
 
Mice homozygous for a knock-out allele exhibit a short tail and abnormal rib, somite, and lung development. Mice homozygous mice exhibit reduced female fertility, abnormal hair cells, and abnormal axial skeleton morphology.
 
Interactions
Lfng interacts with 144 markers (Mir1a-2, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (174 records)
Data Summary: Results (243)    Tissues (111)    Images (117)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 231
Northern blot 10
RT-PCR 2
cDNA source data(57)
Other mouse links: GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA LFNG ; Xenbase lfng ; ZFIN lfng    NEW 
Molecular
reagents
All nucleic(73) cDNA(59) Primer pair(1) Other(13)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000029570 (Evidence)
Entrez Gene 16848 (Evidence)
UniGene 12834
DFCI TC1583479, TC1602090
DoTS DT.492479
NIA Mouse Gene Index U006376
EC 2.4.1.222
Consensus CDS Project CCDS19821.1
International Mouse Phenotyping Consortium Status Lfng
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029570 Ensembl Gene Model | MGI Sequence Detail 8203 C57BL/6J ±  kb
transcript ENSMUST00000031555 Ensembl | MGI Sequence Detail 2282 Not Applicable 
polypeptide ENSMUSP00000031555 Ensembl | MGI Sequence Detail 378 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(10 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017374 Fringe
InterPro IPR003378 Fringe-like
Protein Ontology PR:000009765 beta-1,3-N-acetylglucosaminyltransferase lunatic fringe
References
(Earliest) J:41128 Johnston SH, et al., A family of mammalian Fringe genes implicated in boundary determination and the Notch pathway. Development. 1997 Jun;124(11):2245-54
(Latest) J:220849 Achilleos A, et al., MBTPS1/SKI-1/S1P proprotein convertase is required for ECM signaling and axial elongation during somitogenesis and vertebral developmentdagger. Hum Mol Genet. 2015 May 15;24(10):2884-98
All references(223)
Other
accession IDs
MGI:2141150

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory