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Nup214
Gene Detail
Symbol

Name
ID
Nup214
nucleoporin 214
MGI:1095411
Synonyms
CAN, D2H9S46E
Feature Type
protein coding gene
Genetic Map
Chromosome 2
21.97 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr2:31974436-32053975 bp, + strand
From VEGA annotation of GRCm38

  79540 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38008  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: NUP214
Gene Tree: Nup214

Human
homologs
NUP214, nucleoporin 214kDa
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 8021
neXtProt AC: NX_P35658

Human Synonyms: CAIN, CAN, D9S46E, N214, p250

Human Chr (Location): 9q34.1; chr9:131124959-131234670 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(54) : Gene trapped(51) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Embryos homozygous for a null mutation die between 4.0 and 4.5 dpc, following depletion of maternally-derived gene product. In vitro, cultured 3.5-dpc mutant embryos arrest in the G2 phase, and show blastocoel contraction with defects in NLS-mediated protein import and polyadenylated RNA export.
 
Interactions
Nup214 interacts with 177 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process mRNA export from nucleus, mRNA transport, ...
Component cell, focal adhesion, ...
Function nucleocytoplasmic transporter activity
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (3)    Tissues (2)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 1
cDNA source data(7)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nup214    NEW 
Molecular
reagents
All nucleic(9) cDNA(8) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000012954 (Evidence)
Ensembl Gene Model ENSMUSG00000001855 (Evidence)
Entrez Gene 227720 (Evidence)
NIA Mouse Gene Index U001609
Consensus CDS Project CCDS38098.1
International Mouse Phenotyping Consortium Status Nup214
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012954 VEGA Gene Model | MGI Sequence Detail 79540 C57BL/6J ±  kb
transcript OTTMUST00000031160 VEGA | MGI Sequence Detail 6605 Not Applicable 
polypeptide OTTMUSP00000013944 VEGA | MGI Sequence Detail 2085 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(6) UniProt(7)
Polymorphisms
RFLP(2) : SNPs within 2kb(241 from dbSNP Build 137)    SNPs within 2kb including multiple locations(245)
Protein-related
information
ResourceIDDescription
InterPro IPR001680 WD40 repeat
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000011515 nuclear pore complex protein Nup214
References
(Earliest) J:14384 Copeland NG, et al., A genetic linkage map of the mouse: current applications and future prospects [see comments]. Science. 1993 Oct 1;262(5130):57-66
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(35)
Other
accession IDs
MGD-MRK-5812, MGI:2446288, MGI:91943

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory