About   Help   FAQ
Msh3 Gene Detail
Summary
  • Symbol
    Msh3
  • Name
    mutS homolog 3
  • Synonyms
    D13Em1, Rep3, Rep-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:109519
    NCBI Gene: 17686
  • Gene Overview
    MyGene.info: MSH3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr13:92211872-92355003 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      143132 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 47.63 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    MSH3, mutS homolog 3
  • Vertebrate Orthologs
    11
  • Human Ortholog
    MSH3, mutS homolog 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DUP, FAP4, MRP1
  • Links
    NCBI Gene ID: 4437
    neXtProt AC: NX_P20585
    UniProt: P20585

  • Chr Location
    5q14.1; chr5:80654648-80876815 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1829
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MSH3
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human MSH3 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    6 phenotypes from multigenic genotypes
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit a partial defect mismatch repair and development of intestinal tumors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000047254 VEGA Gene Model | MGI Sequence Detail 143132 C57BL/6J ±  kb
    transcript OTTMUST00000122240 VEGA | MGI Sequence Detail 3946 Not Applicable  
    polypeptide OTTMUSP00000067120 VEGA | MGI Sequence Detail 1095 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      940 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • InterPro Domains
      IPR007860 DNA mismatch repair protein MutS, connector domain
      IPR007696 DNA mismatch repair protein MutS, core
      IPR036187 DNA mismatch repair protein MutS, core domain superfamily
      IPR000432 DNA mismatch repair protein MutS, C-terminal
      IPR007695 DNA mismatch repair protein MutS-like, N-terminal
      IPR017261 DNA mismatch repair protein MutS/MSH
      IPR016151 DNA mismatch repair protein MutS, N-terminal
      IPR036678 MutS, connector domain superfamily
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 110
      Genomic 24
      cDNA 84
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-13842, MGD-MRK-13845, MGD-MRK-3409, MGD-MRK-39518
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 4
      Gene Ontology 11
      Phenotypes 25
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:252313 Edwards Y, An Msh3 ATPase domain mutation has no effect on MMR function. BMC Res Notes. 2017 Nov 25;10(1):616

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory