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Nfil3
Gene Detail
Symbol

Name
ID
Nfil3
nuclear factor, interleukin 3, regulated
MGI:109495
Synonyms
E4BP4
Feature Type
protein coding gene
Genetic Map
Chromosome 13
27.68 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr13:52967209-52981073 bp, - strand
From VEGA annotation of GRCm38

  13865 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3928  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NFIL3
Protein SuperFamily: basic leucine zipper (bZIP) transcription factor E4BP4
Gene Tree: Nfil3

Human
homologs
NFIL3, nuclear factor, interleukin 3 regulated
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4783
neXtProt AC: NX_Q16649

Human Synonyms: E4BP4, IL3BP1, NFIL3A, NF-IL3A

Human Chr (Location): 9q22; chr9:91409045-91424626 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(2) Targeted(8)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele exhibit decreased NK cell differentiation, numbers, and activity. Mice homozygous for a different knock-out allele exhibit reduced class switching and IgE production.
 
Interactions
Nfil3 interacts with 67 markers (Mir10a, Mir16-2, Mir101a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process cellular response to interleukin-4, circadian rhythm, ...
Component nucleus
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (198)    Tissues (78)    Images (39)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 163
In situ reporter (knock in) 16
Northern blot 3
RT-PCR 16
cDNA source data(25)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA NFIL3 ; Xenbase nfil3 ; ZFIN nfil3    NEW 
Molecular
reagents
All nucleic(28) cDNA(25) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000020972 (Evidence)
Ensembl Gene Model ENSMUSG00000056749 (Evidence)
Entrez Gene 18030 (Evidence)
UniGene 136604
DFCI TC1582388
DoTS DT.101380352, DT.94291538, DT.94291536, DT.486929
NIA Mouse Gene Index U034784
Consensus CDS Project CCDS26519.1
International Mouse Phenotyping Consortium Status Nfil3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020972 VEGA Gene Model | MGI Sequence Detail 13865 C57BL/6J ±  kb
transcript OTTMUST00000049595 VEGA | MGI Sequence Detail 2026 Not Applicable 
polypeptide OTTMUSP00000023004 VEGA | MGI Sequence Detail 462 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(12) UniProt(2)
Polymorphisms
SNPs within 2kb(66 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004827 Basic-leucine zipper domain
InterPro IPR016743 Transcription factor, basic leucine zipper, E4BP4
InterPro IPR010533 Vertebrate interleukin-3 regulated transcription factor
Protein Ontology PR:000011176 nuclear factor interleukin-3-regulated protein
References
(Earliest) J:38981 Wallace AD, et al., Inducibility of E4BP4 suggests a novel mechanism of negative gene regulation by glucocorticoids. Biochem Biophys Res Commun. 1997 Mar 17;232(2):403-6
(Latest) J:219798 Zhu C, et al., An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction. Nat Commun. 2015;6:6072
All references(65)
Other
accession IDs
MGD-MRK-39494, MGI:2145396

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory