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Nfil3 Gene Detail
Summary
  • Symbol
    Nfil3
  • Name
    nuclear factor, interleukin 3, regulated
  • Synonyms
    E4BP4
  • Feature Type
    protein coding gene
  • IDs
    MGI:109495
    NCBI Gene: 18030
  • Gene Overview
    MyGene.info: NFIL3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr13:52967209-52981073 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13865 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 27.68 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    NFIL3, nuclear factor, interleukin 3 regulated
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NFIL3, nuclear factor, interleukin 3 regulated
    Orthology source: HomoloGene, HGNC
  • Synonyms
    E4BP4, IL3BP1, NFIL3A, NF-IL3A
  • Links
    NCBI Gene ID: 4783
    neXtProt AC: NX_Q16649
    UniProt: Q16649

  • Chr Location
    9q22.31; chr9:91409045-91425063 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Nfil3 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    46 phenotypes from 6 alleles in 8 genetic backgrounds
    8 phenotypes from multigenic genotypes
    41 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased NK cell differentiation, numbers, and activity. Mice homozygous for a different knock-out allele exhibit reduced class switching and IgE production.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000020972 VEGA Gene Model | MGI Sequence Detail 13865 C57BL/6J ±  kb
    transcript OTTMUST00000049595 VEGA | MGI Sequence Detail 2026 Not Applicable  
    polypeptide OTTMUSP00000023004 VEGA | MGI Sequence Detail 462 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      65 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000011176 nuclear factor interleukin-3-regulated protein
    • InterPro Domains
      IPR004827 Basic-leucine zipper domain
      IPR016743 Nuclear factor interleukin-3-regulated protein
      IPR010533 Vertebrate interleukin-3 regulated transcription factor
    Molecular
    Reagents
    less
    • All nucleic 28
      cDNA 25
      Primer pair 2
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-39494, MGI:2145396
    References
    more
    • Summaries
      All 84
      Developmental Gene Expression 7
      Diseases 1
      Gene Ontology 8
      Phenotypes 41
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:260452 Miyai T, et al., Three-step transcriptional priming that drives the commitment of multipotent progenitors toward B cells. Genes Dev. 2018 Jan 15;32(2):112-126

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory