Epha8
Gene Detail

Symbol Name ID

Epha8 Eph receptor A8 MGI:109378

Synonyms

Eek, EphA8, Hek3

Feature Type

protein coding gene

Genetic Map

Chromosome 4

69.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr4:136929419-136956816 bp, - strand From VEGA annotation of GRCm38   27398 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:22436  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: tyrosine-protein kinase, ephrin receptor type
Gene Tree: Epha8

Human homologs

Human Homolog		EPHA8, EPH receptor A8
NCBI Gene ID		2046
neXtProt AC		NX_P29322
Human Synonyms		EEK, EK3, HEK3
Human Chr (Location)		1p36.12; chr1:22890004-22930087 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for this targeted mutation are viable, fertile, and grossly normal but exhibit a commissural defect, whereby tectal axons fail to project from the superior colliculus of the midbrain to the contralateral inferior colliculus and instead project to the ipsilateral cervical spinal cord.

 

Gene Ontology (GO) classifications

All GO classifications: (42 annotations)

Process	axon guidance, cell adhesion, ...
Component	cell projection, endosome, ...
Function	ATP binding, ephrin receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (21 records)
Data Summary: Results (329)    Tissues (175)    Images (54)
Theiler Stages: 19, 20, 21, 22, 23, 24, 28

Assay Type	Results
RNA in situ	321
RT-PCR	8

cDNA source data(15)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(20) Genomic(1) cDNA(15) Primer pair(3) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000009825 (Evidence)
Ensembl Gene Model	ENSMUSG00000028661 (Evidence)
Entrez Gene	13842 (Evidence)
UniGene	1390
DFCI	TC1586758
DoTS	DT.60105185
NIA Mouse Gene Index	U025675
EC	2.7.10.1
Consensus CDS Project	CCDS18813.1
International Mouse Knockout Project Status	Epha8

Sequences

Length	Strain/Species
genomic	OTTMUSG00000009825	VEGA Gene Model | MGI Sequence Detail	27398	C57BL/6J
transcript	OTTMUST00000022757	VEGA | MGI Sequence Detail	4713	Not Applicable
polypeptide	OTTMUSP00000010386	VEGA | MGI Sequence Detail	1004	Not Applicable

All sequences(19) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(179 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001090	Ephrin receptor ligand binding domain
InterPro	IPR020691	Ephrin type-A receptor 8
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR008979	Galactose-binding domain-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro	IPR001660	Sterile alpha motif domain
InterPro	IPR013761	Sterile alpha motif/pointed domain
InterPro	IPR021129	Sterile alpha motif, type 1
InterPro	IPR008266	Tyrosine-protein kinase, active site
InterPro	IPR020635	Tyrosine-protein kinase, catalytic domain
InterPro	IPR016257	Tyrosine-protein kinase, ephrin receptor
InterPro	IPR001426	Tyrosine-protein kinase, receptor class V, conserved site
Protein Ontology	PR:000007128	ephrin type-A receptor 8

References

(Earliest) J:38350 Park S, et al., The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands. Oncogene. 1997 Feb 6;14(5):533-42
(Latest) J:171255 Yoo S, et al., Endocytosis of EphA receptors is essential for the proper development of the retinocollicular topographic map. EMBO J. 2011 Apr 20;30(8):1593-607
All references(56)

Other accession IDs

MGD-MRK-38423, MGI:2140543