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Epha8 Gene Detail
Summary
  • Symbol
    Epha8
  • Name
    Eph receptor A8
  • Synonyms
    Eek, EphA8, Hek3
  • Feature Type
    protein coding gene
  • IDs
    MGI:109378
    NCBI Gene: 13842
  • Gene Overview
    MyGene.info: EPHA8
Location & Maps
more
  • Sequence Map
    Chr4:136929419-136956816 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      27398 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 69.05 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    EPHA8, EPH receptor A8
  • Vertebrate Orthologs
    7
  • Human Ortholog
    EPHA8, EPH receptor A8
    Orthology source: HomoloGene
  • Synonyms
    EEK, EK3, HEK3
  • Links
    NCBI Gene ID: 2046
    neXtProt AC: NX_P29322

  • Chr Location
    1p36.12; chr1:22563508-22603594 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (other)
    2
  • Targeted
    5
  • Genomic Mutations
    3 involving Epha8
  • Incidental Mutations
Mice homozygous for this targeted mutation are viable, fertile, and grossly normal but exhibit a commissural defect, whereby tectal axons fail to project from the superior colliculus of the midbrain to the contralateral inferior colliculus and instead project to the ipsilateral cervical spinal cord.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009825 VEGA Gene Model | MGI Sequence Detail 27398 C57BL/6J ±  kb
transcript OTTMUST00000022757 VEGA | MGI Sequence Detail 4713 Not Applicable  
polypeptide OTTMUSP00000010386 VEGA | MGI Sequence Detail 1004 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    420 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000007128 ephrin type-A receptor 8
  • EC
  • InterPro Domains
    IPR001090 Ephrin receptor ligand binding domain
    IPR027936 Ephrin receptor, transmembrane domain
    IPR016257 Ephrin receptor type-A /type-B
    IPR020691 Ephrin type-A receptor 8
    IPR003961 Fibronectin type III
    IPR008979 Galactose-binding domain-like
    IPR013783 Immunoglobulin-like fold
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
    IPR001660 Sterile alpha motif domain
    IPR013761 Sterile alpha motif/pointed domain
    IPR008266 Tyrosine-protein kinase, active site
    IPR020635 Tyrosine-protein kinase, catalytic domain
    IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
    IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
Molecular
Reagents
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  • All nucleic 22
    Genomic 1
    cDNA 16
    Primer pair 4
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-38423, MGI:2140543
References
more
  • Summaries
    All 56
    Developmental Gene Expression 25
    Gene Ontology 11
    Phenotypes 6
  • Earliest
    J:38350 Park S, et al., The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands. Oncogene. 1997 Feb 6;14(5):533-42
  • Latest
    J:230727 Stark DA, et al., Ephrin-A3 promotes and maintains slow muscle fiber identity during postnatal development and reinnervation. J Cell Biol. 2015 Dec 7;211(5):1077-91

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory