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Epha8
Gene Detail
Symbol

Name
ID
Epha8
Eph receptor A8
MGI:109378
Synonyms
Eek, EphA8, Hek3
Feature Type
protein coding gene
Genetic Map
Chromosome 4
69.05 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:136929419-136956816 bp, - strand
From VEGA annotation of GRCm38

  27398 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22436  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: EPHA8
Protein SuperFamily: tyrosine-protein kinase, ephrin receptor type
Gene Tree: Epha8

Human
homologs
EPHA8, EPH receptor A8
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2046
neXtProt AC: NX_P29322

Human Synonyms: EEK, EK3, HEK3

Human Chr (Location): 1p36.12; chr1:22563508-22603594 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Genomic Mutations involving Epha8 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for this targeted mutation are viable, fertile, and grossly normal but exhibit a commissural defect, whereby tectal axons fail to project from the superior colliculus of the midbrain to the contralateral inferior colliculus and instead project to the ipsilateral cervical spinal cord.
 
Interactions
Epha8 interacts with 228 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (41 annotations)
Process axon guidance, cell adhesion, ...
Component cell projection, endosome, ...
Function ATP binding, ephrin receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (22 records)
Data Summary: Results (332)    Tissues (178)    Images (56)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 322
RT-PCR 10
cDNA source data(16)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) Genomic(1) cDNA(16) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000009825 (Evidence)
Ensembl Gene Model ENSMUSG00000028661 (Evidence)
Entrez Gene 13842 (Evidence)
UniGene 1390
DFCI TC1586758
DoTS DT.60105185
NIA Mouse Gene Index U025675
EC 2.7.10.1
Consensus CDS Project CCDS18813.1
International Mouse Phenotyping Consortium Status Epha8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009825 VEGA Gene Model | MGI Sequence Detail 27398 C57BL/6J ±  kb
transcript OTTMUST00000022757 VEGA | MGI Sequence Detail 4713 Not Applicable 
polypeptide OTTMUSP00000010386 VEGA | MGI Sequence Detail 1004 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(8) UniProt(2)
Polymorphisms
SNPs within 2kb(424 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001090 Ephrin receptor ligand binding domain
InterPro IPR020691 Ephrin type-A receptor 8
InterPro IPR003961 Fibronectin, type III
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR001660 Sterile alpha motif domain
InterPro IPR013761 Sterile alpha motif/pointed domain
InterPro IPR021129 Sterile alpha motif, type 1
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR016257 Tyrosine-protein kinase, ephrin receptor
InterPro IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
Protein Ontology PR:000007128 ephrin type-A receptor 8
References
(Earliest) J:38350 Park S, et al., The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands. Oncogene. 1997 Feb 6;14(5):533-42
(Latest) J:217584 Gerstmann K, et al., Thalamic afferents influence cortical progenitors via ephrin A5-EphA4 interactions. Development. 2015 Jan 1;142(1):140-50
All references(55)
Other
accession IDs
MGD-MRK-38423, MGI:2140543

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory