Epha8 MGI Mouse Gene Detail - MGI:109378

Symbol

Epha8
Name

Eph receptor A8
Synonyms

Eek, EphA8, Hek3

Feature Type

protein coding gene
IDs

MGI:109378
NCBI Gene: 13842
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr4:136656730-136684127 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 69.05 cM
Mapping Data

2 experiments

SNPs within 2kb

878 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_109378	protein coding gene	Chr4:136656729-136684170 (-)
129S1/SvImJ	ENSMUSG00200019268	protein coding gene	Chr4:130074420-130101819 (-)
A/J	ENSMUSG00195043456	protein coding gene	Chr4:131428484-131455943 (-)
AKR/J	ENSMUSG00220043437	protein coding gene	Chr4:130420248-130447703 (-)
BALB/cJ	ENSMUSG00180046642	protein coding gene	Chr4:129064875-129092292 (-)
C3H/HeJ	ENSMUSG00175031924	protein coding gene	Chr4:130086366-130113776 (-)
C57BL/6NJ	ENSMUSG00215051143	protein coding gene	Chr4:131597261-131624661 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026671	protein coding gene	Chr4:126613750-126641132 (-)
CAST/EiJ	ENSTCUG00005044429	protein coding gene	Chr4:131005361-131032920 (-)
CBA/J	ENSMUSG00210053347	protein coding gene	Chr4:129710284-129737697 (-)
DBA/2J	ENSMUSG00185051722	protein coding gene	Chr4:131238170-131265585 (-)
FVB/NJ	ENSMUSG00205045836	protein coding gene	Chr4:129478691-129506099 (-)
JF1/MsJ	ENSUMUG00000032967	protein coding gene	Chr4:131931271-131958672 (-)
LP/J	ENSMUSG00230033370	protein coding gene	Chr4:135012595-135039990 (-)
NOD/ShiLtJ	ENSMUSG00190042776	protein coding gene	Chr4:129470181-129497593 (-)
NZO/HlLtJ	ENSMUSG00225025136	protein coding gene	Chr4:140967687-140995084 (-)
PWK/PhJ	ENSLUMG00010045020	protein coding gene	Chr4:128918160-128945620 (-)
SPRET/EiJ	ENSMSPG00010038706	protein coding gene	Chr4:130988213-131015641 (-)
WSB/EiJ	ENSIUOG00005035216	protein coding gene	Chr4:129366032-129393470 (-)

Human Ortholog

EPHA8, EPH receptor A8

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EPHA8, EPH receptor A8
Synonyms

EEK, EK3, HEK3
Links

HGNC:3391

NCBI Gene ID: 2046

UniProt: P29322
Chr Location

1p36.12; chr1:22563489-22603595 (+) GRCh38

MGI Vertebrate Homology

Epha8 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: EPHA8
Protein SuperFamily

TyrPK_ephrin_receptor
Gene Tree

Epha8

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Phenotype Summary

3 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

2
Endonuclease-mediated

2
Targeted

5
Genomic Mutations

3 involving Epha8
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

73 strains or lines available

Mice homozygous for this targeted mutation are viable, fertile, and grossly normal but exhibit a commissural defect, whereby tectal axons fail to project from the superior colliculus of the midbrain to the contralateral inferior colliculus and instead project to the ipsilateral cervical spinal cord.

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All GO Annotations

42
GO References

16

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

957
Tissues

200
cDNA Data

18
Literature Summary

35

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas

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All Sequences

37
RefSeq

8
UniProt

2
CCDS

CCDS18813.1

Ensembl

ENSMUSG00000028661 (Evidence)
NCBI Gene

13842

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028661	Ensembl Gene Model \| MGI Sequence Detail	27398	C57BL/6J	± kb
transcript	ENSMUST00000030420	Ensembl \| MGI Sequence Detail	4713	Not Applicable
polypeptide	ENSMUSP00000030420	Ensembl \| MGI Sequence Detail	1004	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000007128 ephrin type-A receptor 8

(term hierarchy)
PDB

8J1I
EC

2.7.10.1
InterPro Domains

IPR061283 Ephrin, cysteine rich domain

IPR001090 Ephrin, ligand binding domain

IPR016257 Ephrin receptor type-A /type-B

IPR050449 Ephrin receptor tyrosine kinases

IPR027936 Ephrin, transmembrane domain

IPR034287 Ephrin type-A receptor 8, ligand binding domain

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR008979 Galactose-binding-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

IPR001660 Sterile alpha motif domain

IPR013761 Sterile alpha motif/pointed domain superfamily

IPR008266 Tyrosine-protein kinase, active site

IPR020635 Tyrosine-protein kinase, catalytic domain

IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
GlyGen

O09127 4 sites, 1 N-linked glycan (1 site)

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All nucleic 27

Genomic 1

cDNA 18

Primer pair 5

Other 3

Microarray probesets 3

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MGD-MRK-38423, MGI:2140543

Summaries

All 79

Developmental Gene Expression 35

Gene Ontology 16

Phenotypes 7
Earliest

J:38350 Park S, et al., The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands. Oncogene. 1997 Feb 6;14(5):533-42
Latest

J:390120 Trowe MO, et al., Mesenchymal WNT signaling coordinates epithelial and mesenchymal differentiation in the developing murine ureter. Cell Commun Signal. 2026 Jul 21;24(1)

TSS for Epha8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr44104	Chr4:136684095-136684182 (-)	-12 bp
Tssr44103	Chr4:136683882-136683889 (-)	241 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24