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Hmox2 Gene Detail
Summary
  • Symbol
    Hmox2
  • Name
    heme oxygenase 2
  • Synonyms
    HO2, HO-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:109373
    NCBI Gene: 15369
  • Gene Overview
    MyGene.info: HMOX2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr16:4726361-4766742 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      40382 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 2.46 cM, cytoband B1
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    HMOX2, heme oxygenase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HMOX2, heme oxygenase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HO-2
  • Links
    NCBI Gene ID: 3163
    neXtProt AC: NX_P30519
    UniProt: P30519

  • Chr Location
    16p13.3; chr16:4474697-4510347 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 2 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene are normal for the most part. However, they are sensitive to incrreases and decreases in oxygen levels and this results in some behavioral and nervous system response abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000026637 VEGA Gene Model | MGI Sequence Detail 40382 C57BL/6J ±  kb
    transcript OTTMUST00000065914 VEGA | MGI Sequence Detail 1730 Not Applicable  
    polypeptide OTTMUSP00000032915 VEGA | MGI Sequence Detail 315 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      94 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 51
      cDNA 51

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-38418
    References
    more
    • Summaries
      All 79
      Developmental Gene Expression 6
      Gene Ontology 5
      Phenotypes 47
    • Earliest
      J:29523 Poss KD, et al., Hippocampal long-term potentiation is normal in heme oxygenase-2 mutant mice. Neuron. 1995 Oct;15(4):867-73
    • Latest
      J:224109 Kang L, et al., Induction and functional significance of the heme oxygenase system in pathological shear stress in vivo. Am J Physiol Heart Circ Physiol. 2015 Jun 1;308(11):H1402-13

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory