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Stx1a Gene Detail
Summary
  • Symbol
    Stx1a
  • Name
    syntaxin 1A (brain)
  • Synonyms
    HPC-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:109355
    NCBI Gene: 20907
  • Gene Overview
    MyGene.info: STX1A
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr5:135023482-135051100 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      27619 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 74.95 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    STX1A, syntaxin 1A
  • Vertebrate Orthologs
    8
  • Human Ortholog
    STX1A, syntaxin 1A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HPC-1, P35-1, STX1, SYN1A
  • Links
    NCBI Gene ID: 6804
    neXtProt AC: NX_Q16623
    UniProt: Q16623

  • Chr Location
    7q11.23; chr7:73699205-73719702 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Stx1a mouse models

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 5 alleles in 6 genetic backgrounds
    8 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mice for one targeted mutation display impairments in LTP, cued fear memory consolidation and cued fear memory extinction while mice with another targeted mutation show no behavioral abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000016270 VEGA Gene Model | MGI Sequence Detail 27619 C57BL/6J ±  kb
    transcript OTTMUST00000039031 VEGA | MGI Sequence Detail 2162 Not Applicable  
    polypeptide OTTMUSP00000017437 VEGA | MGI Sequence Detail 288 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      105 from dbSNP Build 142
    • PCR
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 46
      Genomic 4
      cDNA 40
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-38400
    References
    more
    • Summaries
      All 162
      Developmental Gene Expression 63
      Diseases 3
      Gene Ontology 30
      Phenotypes 28
    • Earliest
      J:23761 Katagiri H, et al., A novel isoform of syntaxin-binding protein homologous to yeast Sec1 expressed ubiquitously in mammalian cells. J Biol Chem. 1995 Mar 10;270(10):4963-6
    • Latest
      J:255335 Tan GH, et al., PRRT2 deficiency induces paroxysmal kinesigenic dyskinesia by regulating synaptic transmission in cerebellum. Cell Res. 2018 Jan;28(1):90-110

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory