Stx1a
Gene Detail

Symbol Name ID

Stx1a syntaxin 1A (brain) MGI:109355

Synonyms

HPC-1

Feature Type

protein coding gene

Genetic Map

Chromosome 5

74.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr5:135023482-135051100 bp, + strand From VEGA annotation of GRCm38   27619 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37941  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: syntaxin
Gene Tree: Stx1a

Human homologs

Human Homolog		STX1A, syntaxin 1A (brain)
NCBI Gene ID		6804
neXtProt AC		NX_Q16623
Human Synonyms		HPC-1, P35-1, STX1, SYN1A
Human Chr (Location)		7q11.23; chr7:73113535-73134017 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(15) : Targeted(7) Gene trapped(8)
 

Homozygous mice for one targeted mutation display impairments in LTP, cued fear memory consolidation and cued fear memory extinction while mice with another targeted mutation show no behavioral abnormalities.

 

Gene Ontology (GO) classifications

All GO classifications: (56 annotations)

Process	calcium ion-dependent exocytosis, exocytosis, ...
Component	actomyosin, cell junction, ...
Function	ATP-dependent protein binding, calcium channel inhibitor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (51 records)
Data Summary: Results (26)    Tissues (18)    Images (13)
Theiler Stages: 20, 22, 24, 26, 28

Assay Type	Results
Immunohistochemistry	4
RNA in situ	12
Western blot	10

cDNA source data(37)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(43) Genomic(4) cDNA(38) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000016270 (Evidence)
Ensembl Gene Model	ENSMUSG00000007207 (Evidence)
Entrez Gene	20907 (Evidence)
UniGene	6225
DFCI	TC1575536, TC1602452
DoTS	DT.101219424, DT.101377288, DT.55254693, DT.97359485
NIA Mouse Gene Index	U006275
Consensus CDS Project	CCDS19731.1
International Mouse Knockout Project Status	Stx1a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016270	VEGA Gene Model | MGI Sequence Detail	27619	C57BL/6J
transcript	OTTMUST00000039031	VEGA | MGI Sequence Detail	2162	Not Applicable
polypeptide	OTTMUSP00000017437	VEGA | MGI Sequence Detail	288	Not Applicable

All sequences(39) RefSeq(2) UniProt(4)

Polymorphisms

PCR(1) : SNPs(103 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR015709	Syntaxin-1
InterPro	IPR006012	Syntaxin/epimorphin, conserved site
InterPro	IPR006011	Syntaxin, N-terminal
InterPro	IPR000727	Target SNARE coiled-coil domain
InterPro	IPR010989	t-SNARE
Protein Ontology	PR:000015792	syntaxin-1A

References

(Earliest) J:23761 Katagiri H, et al., A novel isoform of syntaxin-binding protein homologous to yeast Sec1 expressed ubiquitously in mammalian cells. J Biol Chem. 1995 Mar 10;270(10):4963-6
(Latest) J:193122 Zhou P, et al., Syntaxin-1 N-peptide and Habc-domain perform distinct essential functions in synaptic vesicle fusion. EMBO J. 2013 Jan 9;32(1):159-71
All references(120)

Other accession IDs

MGD-MRK-38400