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Stx1a
Gene Detail
Symbol

Name
ID
Stx1a
syntaxin 1A (brain)
MGI:109355
Synonyms
HPC-1
Feature Type
protein coding gene
Genetic Map
Chromosome 5
74.95 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr5:135023482-135051100 bp, + strand
From VEGA annotation of GRCm38

  27619 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37941  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: STX1A
Protein SuperFamily: syntaxin
Gene Tree: Stx1a

Human
homologs
STX1A, syntaxin 1A (brain)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6804
neXtProt AC: NX_Q16623

Human Synonyms: HPC-1, P35-1, STX1, SYN1A

Human Chr (Location): 7q11.23; chr7:73699205-73719702 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(8) Targeted(10)
Genomic Mutations involving Stx1a (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mice for one targeted mutation display impairments in LTP, cued fear memory consolidation and cued fear memory extinction while mice with another targeted mutation show no behavioral abnormalities.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Stx1a interacts with 229 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (74 annotations)
Process calcium ion-dependent exocytosis, exocytosis, ...
Component actomyosin, cell, ...
Function ATP-dependent protein binding, calcium channel inhibitor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (54 records)
Data Summary: Results (30)    Tissues (20)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 8
RNA in situ 12
Western blot 10
cDNA source data(38)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase stx1a    NEW 
Molecular
reagents
All nucleic(44) Genomic(4) cDNA(39) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000016270 (Evidence)
Ensembl Gene Model ENSMUSG00000007207 (Evidence)
Entrez Gene 20907 (Evidence)
UniGene 6225
DFCI TC1602452, TC1575536
DoTS DT.101377288, DT.101219424, DT.55254693, DT.97359485
NIA Mouse Gene Index U006275
Consensus CDS Project CCDS19731.1
International Mouse Phenotyping Consortium Status Stx1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016270 VEGA Gene Model | MGI Sequence Detail 27619 C57BL/6J ±  kb
transcript OTTMUST00000039031 VEGA | MGI Sequence Detail 2162 Not Applicable 
polypeptide OTTMUSP00000017437 VEGA | MGI Sequence Detail 288 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(6) UniProt(4)
Polymorphisms
PCR(1) : SNPs within 2kb(105 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006012 Syntaxin/epimorphin, conserved site
InterPro IPR006011 Syntaxin, N-terminal
InterPro IPR000727 Target SNARE coiled-coil domain
InterPro IPR010989 t-SNARE
Protein Ontology PR:000015792 syntaxin-1A
References
(Earliest) J:23761 Katagiri H, et al., A novel isoform of syntaxin-binding protein homologous to yeast Sec1 expressed ubiquitously in mammalian cells. J Biol Chem. 1995 Mar 10;270(10):4963-6
(Latest) J:221268 Acuna C, et al., Microsecond dissection of neurotransmitter release: SNARE-complex assembly dictates speed and Ca(2)(+) sensitivity. Neuron. 2014 Jun 4;82(5):1088-100
All references(134)
Other
accession IDs
MGD-MRK-38400

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory