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Ucp2
Gene Detail
Symbol

Name
ID
Ucp2
uncoupling protein 2 (mitochondrial, proton carrier)
MGI:109354
Feature Type
protein coding gene
Genetic Map
Chromosome 7
54.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr7:100493337-100502020 bp, + strand
From VEGA annotation of GRCm38

  8684 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2516  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Ucp2

Human
homologs
Human Homolog UCP2, uncoupling protein 2 (mitochondrial, proton carrier)
NCBI Gene ID 7351
neXtProt AC  NX_P55851
Human Synonyms  BMIQ4, SLC25A8, UCPH
Human Chr (Location)  11q13; chr11:73974671-73982844 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(46) : Gene trapped(40) Targeted(6)
Incidental mutations (data from APF )
 
Homozygous null mutants have elevated pancreatic islet cell ATP levels and increased glucose-stimulated secretion of insulin. Homozygotes also show reduced mitochondrial proton leak in thymocytes and increased resistance to infection by Toxoplasma gondii.
 
Interactions
Ucp2 interacts with 247 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process mitochondrial transport, negative regulation of apoptotic process, ...
Component integral component of membrane, membrane, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (164)    Tissues (114)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 142
Northern blot 16
RT-PCR 6
cDNA source data(17)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) Genomic(2) cDNA(20) Primer pair(2) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000022804 (Evidence)
Ensembl Gene ModelENSMUSG00000033685 (Evidence)
Entrez Gene22228 (Evidence)
DFCITC1573124
NIA Mouse Gene IndexU008454
PDB2LCK
Consensus CDS ProjectCCDS21498.1
International Mouse Knockout Project StatusUcp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022804 VEGA Gene Model | MGI Sequence Detail 8684 C57BL/6J ±  kb
transcript OTTMUST00000054806 VEGA | MGI Sequence Detail 3988 Not Applicable 
polypeptide OTTMUSP00000026186 VEGA | MGI Sequence Detail 309 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(4) UniProt(13)
Polymorphisms
RFLP(1) : SNPs within 2kb(106 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002030 Mitochondrial brown fat uncoupling protein
InterPro IPR023395 Mitochondrial carrier domain
InterPro IPR018108 Mitochondrial substrate/solute carrier
Protein Ontology PR:000017036 mitochondrial uncoupling protein 2
References
(Earliest) J:38702 Fleury C, et al., Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia [see comments]. Nat Genet. 1997 Mar;15(3):269-72
(Latest) J:212606 Lu M, et al., Uncoupling protein 2 deficiency aggravates astrocytic endoplasmic reticulum stress and nod-like receptor protein 3 inflammasome activation. Neurobiol Aging. 2014 Feb;35(2):421-30
All references(123)
Other
accession IDs
MGD-MRK-38399

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory