Ucp2
Gene Detail

Symbol Name ID

Ucp2 uncoupling protein 2 (mitochondrial, proton carrier) MGI:109354

Feature Type

protein coding gene

Genetic Map

Chromosome 7

54.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr7:100493337-100502020 bp, + strand From VEGA annotation of GRCm38   8684 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2516  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Ucp2

Human homologs

Human Homolog		UCP2, uncoupling protein 2 (mitochondrial, proton carrier)
NCBI Gene ID		7351
neXtProt AC		NX_P55851
Human Synonyms		BMIQ4, SLC25A8, UCPH
Human Chr (Location)		11q13; chr11:73685716-73693889 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(46) : Targeted(6) Gene trapped(40)
 

Homozygous null mutants have elevated pancreatic islet cell ATP levels and increased glucose-stimulated secretion of insulin. Homozygotes also show reduced mitochondrial proton leak in thymocytes and increased resistance to infection by Toxoplasma gondii.

 

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	mitochondrial transport, negative regulation of apoptotic process, ...
Component	integral to membrane, membrane, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (164)    Tissues (114)    Images (24)
Theiler Stages: 15, 17, 19, 22, 23, 28

Assay Type	Results
RNA in situ	142
Northern blot	16
RT-PCR	6

cDNA source data(16)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(25) Genomic(2) cDNA(19) Primer pair(2) Other(2)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000022804 (Evidence)
Ensembl Gene Model	ENSMUSG00000033685 (Evidence)
Entrez Gene	22228 (Evidence)
DFCI	TC1573124
NIA Mouse Gene Index	U008454
PDB	2LCK
Consensus CDS Project	CCDS21498.1
International Mouse Knockout Project Status	Ucp2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000022804	VEGA Gene Model | MGI Sequence Detail	8684	C57BL/6J
transcript	OTTMUST00000054806	VEGA | MGI Sequence Detail	3988	Not Applicable
polypeptide	OTTMUSP00000026186	VEGA | MGI Sequence Detail	309	Not Applicable

All sequences(59) RefSeq(2) UniProt(7)

Polymorphisms

RFLP(1) : SNPs(75 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002030	Mitochondrial brown fat uncoupling protein
InterPro	IPR023395	Mitochondrial carrier domain
InterPro	IPR018108	Mitochondrial substrate/solute carrier
Protein Ontology	PR:000017036	mitochondrial uncoupling protein 2

References

(Earliest) J:38702 Fleury C, et al., Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia [see comments]. Nat Genet. 1997 Mar;15(3):269-72
(Latest) J:190705 Suski JM, et al., Guanosine diphosphate exerts a lower effect on superoxide release from mitochondrial matrix in the brains of uncoupling protein-2 knockout mice: new evidence for a putative novel function of uncoupling proteins as superoxide anion transporters. Biochem Biophys Res Commun. 2012 Nov 16;428(2):234-8
All references(114)

Other accession IDs

MGD-MRK-38399