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Ucp2
Gene Detail
Symbol

Name
ID
Ucp2
uncoupling protein 2 (mitochondrial, proton carrier)
MGI:109354
Feature Type
protein coding gene
Genetic Map
Chromosome 7
54.36 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr7:100493337-100502020 bp, + strand
From VEGA annotation of GRCm38

  8684 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2516  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: UCP2
Gene Tree: Ucp2

Human
homologs
UCP2, uncoupling protein 2 (mitochondrial, proton carrier)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7351
neXtProt AC: NX_P55851

Human Synonyms: BMIQ4, SLC25A8, UCPH

Human Chr (Location): 11q13; chr11:73974671-73982844 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(46) : Gene trapped(40) Targeted(6)
Incidental mutations (data from APF )
 
Homozygous null mutants have elevated pancreatic islet cell ATP levels and increased glucose-stimulated secretion of insulin. Homozygotes also show reduced mitochondrial proton leak in thymocytes and increased resistance to infection by Toxoplasma gondii.
 
Interactions
Ucp2 interacts with 247 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process mitochondrial transport, negative regulation of apoptotic process, ...
Component cytoplasm, integral component of membrane, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (164)    Tissues (114)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 142
Northern blot 16
RT-PCR 6
cDNA source data(17)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase ucp2 ; ZFIN ucp2    NEW 
Molecular
reagents
All nucleic(26) Genomic(2) cDNA(20) Primer pair(2) Other(2)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000022804 (Evidence)
Ensembl Gene Model ENSMUSG00000033685 (Evidence)
Entrez Gene 22228 (Evidence)
DFCI TC1573124
NIA Mouse Gene Index U008454
PDB 2LCK
Consensus CDS Project CCDS21498.1
International Mouse Phenotyping Consortium Status Ucp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022804 VEGA Gene Model | MGI Sequence Detail 8684 C57BL/6J ±  kb
transcript OTTMUST00000054806 VEGA | MGI Sequence Detail 3988 Not Applicable 
polypeptide OTTMUSP00000026186 VEGA | MGI Sequence Detail 309 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(4) UniProt(7)
Polymorphisms
RFLP(1) : SNPs within 2kb(106 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002030 Mitochondrial brown fat uncoupling protein
InterPro IPR023395 Mitochondrial carrier domain
InterPro IPR018108 Mitochondrial substrate/solute carrier
Protein Ontology PR:000017036 mitochondrial uncoupling protein 2
References
(Earliest) J:38702 Fleury C, et al., Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia [see comments]. Nat Genet. 1997 Mar;15(3):269-72
(Latest) J:220392 Moon JS, et al., UCP2-induced fatty acid synthase promotes NLRP3 inflammasome activation during sepsis. J Clin Invest. 2015 Feb;125(2):665-80
All references(129)
Other
accession IDs
MGD-MRK-38399

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory