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Ucp2 Gene Detail
Summary
  • Symbol
    Ucp2
  • Name
    uncoupling protein 2 (mitochondrial, proton carrier)
  • Feature Type
    protein coding gene
  • IDs
    MGI:109354
    NCBI Gene: 22228
  • Gene Overview
    MyGene.info: UCP2
  • Alliance
  • Transcription Start Sites
    28 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:100493358-100499629 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 54.36 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    101 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109354
protein coding gene Chr7:100493337-100502020 (.)
129S1/SvImJ MGP_129S1SvImJ_G0032570
protein coding gene Chr7:103377076-103385742 (+)
A/J MGP_AJ_G0032544
protein coding gene Chr7:100776325-100784991 (+)
AKR/J MGP_AKRJ_G0032480
protein coding gene Chr7:103175941-103184607 (+)
BALB/cJ MGP_BALBcJ_G0032555
protein coding gene Chr7:100452756-100461422 (+)
C3H/HeJ MGP_C3HHeJ_G0032270
protein coding gene Chr7:103553933-103562587 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033053
protein coding gene Chr7:107303753-107312436 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030047
protein coding gene Chr7:103179180-103188584 (+)
CAST/EiJ MGP_CASTEiJ_G0031597
protein coding gene Chr7:95101444-95111120 (+)
CBA/J MGP_CBAJ_G0032237
protein coding gene Chr7:110981405-110990094 (+)
DBA/2J MGP_DBA2J_G0032388
protein coding gene Chr7:99109641-99118321 (+)
FVB/NJ MGP_FVBNJ_G0032345
protein coding gene Chr7:98893763-98902429 (+)
LP/J MGP_LPJ_G0032478
protein coding gene Chr7:104729094-104737760 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032378
protein coding gene Chr7:112412444-112421131 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033075
protein coding gene Chr7:102441479-102450166 (+)
PWK/PhJ MGP_PWKPhJ_G0031315
protein coding gene Chr7:92216738-92227042 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031158
protein coding gene Chr7:89752042-89760715 (+)
WSB/EiJ MGP_WSBEiJ_G0031714
protein coding gene Chr7:103140995-103149678 (+)



Homology
more
  • Human Ortholog
    UCP2, uncoupling protein 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    UCP2, uncoupling protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BMIQ4, SLC25A8, UCPH
  • Links
    NCBI Gene ID: 7351
    neXtProt AC: NX_P55851
    UniProt: P55851

  • Chr Location
    11q13.4; chr11:73974671-73982844 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2516
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: UCP2
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 3 alleles in 6 genetic backgrounds
    6 phenotypes from multigenic genotypes
    89 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants have elevated pancreatic islet cell ATP levels and increased glucose-stimulated secretion of insulin. Homozygotes also show reduced mitochondrial proton leak in thymocytes and increased resistance to infection by Toxoplasma gondii.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22228 NCBI Gene Model | MGI Sequence Detail 6272 C57BL/6J ±  kb
    transcript NM_011671 RefSeq | MGI Sequence Detail 1583 C57BL/6  
    polypeptide P70406 UniProt | EBI | MGI Sequence Detail 309 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      Genomic 2
      cDNA 21
      Primer pair 2
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-38399
    References
    more
    • Summaries
      All 184
      Developmental Gene Expression 18
      Gene Ontology 11
      Phenotypes 89
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:255164 Broche B, et al., Mitochondrial Protein UCP2 Controls Pancreas Development. Diabetes. 2018 Jan;67(1):78-84

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory