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Lama4
Gene Detail
Symbol

Name
ID
Lama4
laminin, alpha 4
MGI:109321
Synonyms
laminin [a]4
Feature Type
protein coding gene
Genetic Map
Chromosome 10
20.02 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:38965515-39110188 bp, + strand
From VEGA annotation of GRCm38

  144674 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37604  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LAMA4
Gene Tree: Lama4

Human
homologs
LAMA4, laminin, alpha 4
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3910
neXtProt AC: NX_Q16363

Human Synonyms: CMD1JJ, LAMA3, LAMA4*-1

Human Chr (Location): 6q21; chr6:112107931-112254722 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human LAMA4

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(4) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted null mutations exhibit impaired motor control of the hind limbs associated with improperly positioned synaptic active zones and junctional folds, and prenatal and neonatal hemorrhages associated with capillary defects.
 
Phenotype Images(7)
Interactions
Lama4 interacts with 69 markers (Mir16-2, Mir19a, Mir27a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process blood vessel development, brown fat cell differentiation, ...
Component basal lamina, basement membrane, ...
Function receptor binding
External Resources: FuncBase
Expression
Literature Summary: (38 records)
Data Summary: Results (50)    Tissues (29)    Images (21)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 18
RNA in situ 32
cDNA source data(92)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase lama4 ; ZFIN lama4    NEW 
Molecular
reagents
All nucleic(100) Genomic(1) cDNA(97) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000034993 (Evidence)
Ensembl Gene Model ENSMUSG00000019846 (Evidence)
Entrez Gene 16775 (Evidence)
UniGene 258065
DFCI TC1578515, TC1646490, TC1619048
DoTS DT.91285992, DT.87033244, DT.493047, DT.91578320, DT.91428828
NIA Mouse Gene Index U011407
Consensus CDS Project CCDS35882.1
International Mouse Phenotyping Consortium Status Lama4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034993 VEGA Gene Model | MGI Sequence Detail 144674 C57BL/6J ±  kb
transcript OTTMUST00000088986 VEGA | MGI Sequence Detail 6046 Not Applicable 
polypeptide OTTMUSP00000048571 VEGA | MGI Sequence Detail 1816 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(2) UniProt(6)
Polymorphisms
RFLP(1) : SNPs within 2kb(803 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR002049 EGF-like, laminin
InterPro IPR001791 Laminin G domain
InterPro IPR009254 Laminin I
InterPro IPR010307 Laminin II
Protein Ontology PR:000009653 laminin subunit alpha-4
References
(Earliest) J:38853 Liu J, et al., The complete cDNA coding sequence and tissue-specific expression of the mouse laminin alpha 4 chain. Matrix Biol. 1996 Dec;15(6):433-7
(Latest) J:217710 Seano G, et al., Endothelial podosome rosettes regulate vascular branching in tumour angiogenesis. Nat Cell Biol. 2014 Oct;16(10):931-41, 1-8
All references(94)
Other
accession IDs
MGD-MRK-38366

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory