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Lama4
Gene Detail
 Symbol
Name
ID
Lama4
laminin, alpha 4
MGI:109321
Synonyms laminin [a]4
Feature Type protein coding gene
Genetic Map
Chromosome 10
20.02 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr10:38965515-39110188 bp, + strand
From VEGA annotation of GRCm38

  144674 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37604  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Lama4

Human
homologs
Human Homolog LAMA4, laminin, alpha 4
NCBI Gene ID 3910
neXtProt AC  NX_Q16363
Human Synonyms  CMD1JJ, LAMA3, LAMA4*-1
Human Chr (Location)  6q21; chr6:112107931-112254722 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human LAMA4
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(4) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit impaired motor control of the hind limbs associated with improperly positioned synaptic active zones and junctional folds, and prenatal and neonatal hemorrhages associated with capillary defects.
 
Phenotype Images(7)
Interactions
Lama4 interacts with 69 markers (Mir16-2, Mir19a, Mir27a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process blood vessel development, brown fat cell differentiation, ...
Component basal lamina, basement membrane, ...
Function receptor binding
External Resources: FuncBase
Expression
Literature Summary: (36 records)
Data Summary: Results (44)    Tissues (23)    Images (21)
Theiler Stages: 11, 17, 20, 21, 23, 24, 28
Assay TypeResults
Immunohistochemistry 12
RNA in situ 32
cDNA source data(92)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(100) Genomic(1) cDNA(97) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000034993 (Evidence)
Ensembl Gene ModelENSMUSG00000019846 (Evidence)
Entrez Gene16775 (Evidence)
UniGene258065
DFCITC1578515, TC1619048, TC1646490
DoTSDT.493047, DT.87033244, DT.91285992, DT.91428828, DT.91578320
NIA Mouse Gene IndexU011407
Consensus CDS ProjectCCDS35882.1
International Mouse Knockout Project StatusLama4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034993 VEGA Gene Model | MGI Sequence Detail 144674 C57BL/6J ±  kb
transcript OTTMUST00000088986 VEGA | MGI Sequence Detail 6046 Not Applicable 
polypeptide OTTMUSP00000048571 VEGA | MGI Sequence Detail 1816 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(2) UniProt(6)
Polymorphisms RFLP(1) : SNPs within 2kb(803 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR002049 EGF-like, laminin
InterPro IPR001791 Laminin G domain
InterPro IPR009254 Laminin I
InterPro IPR010307 Laminin II
Protein Ontology PR:000009653 laminin subunit alpha-4
References (Earliest) J:38853 Liu J, et al., The complete cDNA coding sequence and tissue-specific expression of the mouse laminin alpha 4 chain. Matrix Biol. 1996 Dec;15(6):433-7
(Latest) J:202984 Rockich BE, et al., Sox9 plays multiple roles in the lung epithelium during branching morphogenesis. Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):E4456-64
All references(92)
Other
accession IDs
MGD-MRK-38366

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory