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Inhbe Gene Detail
Summary
  • Symbol
    Inhbe
  • Name
    inhibin beta-E
  • Synonyms
    activin betaE, activin beta-E
  • Feature Type
    protein coding gene
  • IDs
    MGI:109269
    NCBI Gene: 16326
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:127185271-127187717 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 74.50 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    6 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109269
 protein coding gene Chr10:127184726-127190280 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017820
 protein coding gene Chr10:130941828-130944195 (-)
A/J MGP_AJ_G0017795
 protein coding gene Chr10:125703998-125706356 (-)
AKR/J MGP_AKRJ_G0017758
 protein coding gene Chr10:129415408-129417775 (-)
BALB/cJ MGP_BALBcJ_G0017759
 protein coding gene Chr10:126110292-126112650 (-)
C3H/HeJ MGP_C3HHeJ_G0017583
 protein coding gene Chr10:129568556-129570923 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018214
 protein coding gene Chr10:135380705-135383075 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015894
 protein coding gene Chr10:119699566-119701913 (-)
CAST/EiJ MGP_CASTEiJ_G0017143
 protein coding gene Chr10:130222152-130224502 (-)
CBA/J MGP_CBAJ_G0017552
 protein coding gene Chr10:140838396-140840763 (-)
DBA/2J MGP_DBA2J_G0017658
 protein coding gene Chr10:124787115-124789479 (-)
FVB/NJ MGP_FVBNJ_G0017653
 protein coding gene Chr10:123729857-123732218 (-)
LP/J MGP_LPJ_G0017732
 protein coding gene Chr10:131520533-131522897 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017681
 protein coding gene Chr10:143549691-143552052 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018254
 protein coding gene Chr10:129480102-129482472 (-)
PWK/PhJ MGP_PWKPhJ_G0016928
 protein coding gene Chr10:124992668-124995035 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016720
 protein coding gene Chr10:128520439-128522797 (-)
WSB/EiJ MGP_WSBEiJ_G0017204
 protein coding gene Chr10:129710181-129712533 (-)



Homology
more
  • Human Ortholog
    INHBE, inhibin subunit beta E
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    INHBE, inhibin subunit beta E
  • Links
    NCBI Gene ID: 83729
    neXtProt AC: NX_P58166
    UniProt: P58166

  • Chr Location
    12q13.3; chr12:57452323-57459280 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    7 phenotype references
Mice homozygous for a null mutation are fertile with normal liver and reproductive morphology and physiology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    3
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    740
  • Tissues
    27
  • cDNA Data
    6
  • Literature Summary
    5
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 16326 NCBI Gene Model | MGI Sequence Detail 2447 C57BL/6J ±  kb
transcript NM_008382 RefSeq | MGI Sequence Detail 2211 ZRU/MplStud  
polypeptide O08717 UniProt | EBI | MGI Sequence Detail 350 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    Genomic 4
    cDNA 6
    Primer pair 3
    Other 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-38314
References
more
  • Summaries
    All 37
    Developmental Gene Expression 5
    Gene Ontology 3
    Phenotypes 7
  • Earliest
    J:16240 Lu RZ, et al., Developmental expression of activin/inhibin beta A, beta B, and alpha subunits, and activin receptor-IIB genes in preimplantation mouse embryos. Biol Reprod. 1993 Dec;49(6):1163-9
  • Latest
    J:271175 Hashimoto O, et al., Activin E Controls Energy Homeostasis in Both Brown and White Adipose Tissues as a Hepatokine. Cell Rep. 2018 Oct 30;25(5):1193-1203
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory