About   Help   FAQ
Gzmd
Gene Detail
 Symbol
Name
ID
Gzmd
granzyme D
MGI:109255
Synonyms CCP5, Ctla5, Ctla-5
Feature Type protein coding gene
Genetic Map
Chromosome 14
28.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr14:56129556-56132608 bp, - strand
From VEGA annotation of GRCm38

  3053 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:133275  Vertebrate Homology Class
1 human; 4 mouse; 1 rat; 1 chimpanzee

Protein SuperFamily: trypsin
Gene Tree: Gzmd

Human
homologs
Human Homolog GZMH, granzyme H (cathepsin G-like 2, protein h-CCPX)
NCBI Gene ID 2999
neXtProt AC  NX_P20718
Human Synonyms  CCP-X, CGL-2, CSP-C, CTLA1, CTSGL2
Human Chr (Location)  14q11.2; chr14:24606480-24609720 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Gzmd interacts with 21 markers (Mir22, Mir129-1, Mir129-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process cytolysis, granzyme-mediated apoptotic signaling pathway, ...
Component membrane, secretory granule
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (4)    Tissues (2)   
Theiler Stages: 20, 28
Assay TypeResults
RT-PCR 4
cDNA source data(15)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(28) Genomic(11) cDNA(15) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000034670 (Evidence)
Ensembl Gene ModelENSMUSG00000059256 (Evidence)
Entrez Gene14941 (Evidence)
UniGene482071
NIA Mouse Gene IndexU035602
EC3.4.21.-
Consensus CDS ProjectCCDS49502.1
International Mouse Knockout Project StatusGzmd
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034670 VEGA Gene Model | MGI Sequence Detail 3053 C57BL/6J ±  kb
transcript OTTMUST00000088011 VEGA | MGI Sequence Detail 964 Not Applicable 
polypeptide OTTMUSP00000047946 VEGA | MGI Sequence Detail 252 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(4) UniProt(2)
Polymorphisms SNPs within 2kb(197 from dbSNP Build 137)    SNPs within 2kb including multiple locations(211)
Protein-related
information
ResourceIDDescription
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000003475 granzyme D
References (Earliest) J:8216 Lobe CG, et al., Cloning of two genes that are specifically expressed in activated cytotoxic T lymphocytes. Proc Natl Acad Sci U S A. 1986 Mar;83(5):1448-52
(Latest) J:207244 Berezniuk I, et al., Cytosolic carboxypeptidase 5 removes alpha- and gamma-linked glutamates from tubulin. J Biol Chem. 2013 Oct 18;288(42):30445-53
All references(34)
Other
accession IDs
MGD-MRK-2235, MGD-MRK-38300

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/09/2014
MGI 5.19
The Jackson Laboratory