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Fat1 Gene Detail
Summary
  • Symbol
    Fat1
  • Name
    FAT atypical cadherin 1
  • Synonyms
    2310038E12Rik, Fath, mFat1
  • Feature Type
    protein coding gene
  • IDs
    MGI:109168
    NCBI Gene: 14107
Location & Maps
more
  • Sequence Map
    Chr8:44935447-45052257 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      116811 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    FAT1, FAT atypical cadherin 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FAT1, FAT atypical cadherin 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CDHF7, CDHR8, FAT, hFat1, ME5
  • Links
    NCBI Gene ID: 2195
    neXtProt AC: NX_Q14517

  • Chr Location
    4q35; chr4:186587783-186726915 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    39 phenotypes from 6 alleles in 6 genetic backgrounds
    13 images
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    73
  • Chemically induced (other)
    1
  • Gene trapped
    67
  • Targeted
    5
  • Genomic Mutations
    1 involving Fat1
  • Incidental Mutations
Homozygotes for a targeted null mutation exhibit holoprosencephaly, anophthalmia, kidney defects and perinatal lethality. Mice homozygous for a hypomorphic allele exhibit altered shoulder girdle and facial musculature, retinal defects, abnormal inner earpatterning and kidney defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048086 VEGA Gene Model | MGI Sequence Detail 116811 C57BL/6J ±  kb
transcript OTTMUST00000123546 VEGA | MGI Sequence Detail 14814 Not Applicable  
polypeptide OTTMUSP00000067437 VEGA | MGI Sequence Detail 4590 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    675 from dbSNP Build 137
  • PCR
Protein
Information
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Molecular
Reagents
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  • All nucleic 254
    Genomic 2
    cDNA 247
    Primer pair 5

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-38212, MGI:1924002, MGI:2142710
References
more
  • Summaries
    All 40
    Developmental Gene Expression 5
    Gene Ontology 2
    Phenotypes 13
  • Earliest
    J:37528 Skarnes WC, et al., Capturing genes encoding membrane and secreted proteins important for mouse development. Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6592-6
  • Latest
    J:226938 Bagherie-Lachidan M, et al., Stromal Fat4 acts non-autonomously with Dchs1/2 to restrict the nephron progenitor pool. Development. 2015 Aug 1;142(15):2564-73

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory