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Fat1
Gene Detail
Symbol

Name
ID
Fat1
FAT tumor suppressor homolog 1 (Drosophila)
MGI:109168
Synonyms
2310038E12Rik, Fath, mFat1
Feature Type
protein coding gene
Genetic Map
Chromosome 8
24.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr8:44935447-45052257 bp, + strand
From VEGA annotation of GRCm38

  116811 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:66302  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: FAT1
Gene Tree: Fat1

Human
homologs
FAT1, FAT atypical cadherin 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 2195
neXtProt AC: NX_Q14517

Human Synonyms: CDHF7, CDHR8, FAT, hFat1, ME5

Human Chr (Location): 4q35; chr4:186587783-186726915 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(72) : Gene trapped(67) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for a targeted null mutation exhibit holoprosencephaly, anophthalmia, kidney defects and perinatal lethality. Mice homozygous for a hypomorphic allele exhibit altered shoulder girdle and facial musculature, retinal defects, abnormal inner ear patterning and kidney defects.
 
Phenotype Images(13)
Interactions
Fat1 interacts with 304 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process actin filament organization, establishment or maintenance of cell polarity, ...
Component cell-cell junction, cell junction, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (138)    Tissues (77)    Images (51)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 124
RT-PCR 14
cDNA source data(247)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA FAT1 ; Xenbase fat1 ; ZFIN fat1a    NEW 
Molecular
reagents
All nucleic(254) Genomic(2) cDNA(247) Primer pair(5)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000048086 (Evidence)
Ensembl Gene Model ENSMUSG00000070047 (Evidence)
Entrez Gene 14107 (Evidence)
UniGene 27365
DFCI TC1597137, TC1601259, TC1601153
DoTS DT.101384434, DT.94216422, DT.532422, DT.102546021
NIA Mouse Gene Index U009299
Consensus CDS Project CCDS52547.1
International Mouse Phenotyping Consortium Status Fat1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048086 VEGA Gene Model | MGI Sequence Detail 116811 C57BL/6J ±  kb
transcript OTTMUST00000123546 VEGA | MGI Sequence Detail 14814 Not Applicable 
polypeptide OTTMUSP00000067437 VEGA | MGI Sequence Detail 4590 Not Applicable 

For the selected sequences
All sequences(87) RefSeq(24) UniProt(11)
Polymorphisms
PCR(2) : SNPs within 2kb(675 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002126 Cadherin
InterPro IPR020894 Cadherin conserved site
InterPro IPR015919 Cadherin-like
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR001791 Laminin G domain
Protein Ontology PR:000007350 protocadherin Fat 1
References
(Earliest) J:37528 Skarnes WC, et al., Capturing genes encoding membrane and secreted proteins important for mouse development. Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6592-6
(Latest) J:199157 Caruso N, et al., Deregulation of the Protocadherin Gene FAT1 Alters Muscle Shapes: Implications for the Pathogenesis of Facioscapulohumeral Dystrophy. PLoS Genet. 2013 Jun;9(6):e1003550
All references(43)
Other
accession IDs
MGD-MRK-38212, MGI:1924002, MGI:2142710

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory