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Fat1 Gene Detail
Summary
  • Symbol
    Fat1
  • Name
    FAT atypical cadherin 1
  • Synonyms
    2310038E12Rik, Fath, mFat1
  • Feature Type
    protein coding gene
  • IDs
    MGI:109168
    NCBI Gene: 14107
  • Gene Overview
    MyGene.info: FAT1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr8:44935447-45052257 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      116811 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 8, 24.81 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    FAT1, FAT atypical cadherin 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    FAT1, FAT atypical cadherin 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CDHF7, CDHR8, FAT, hFat1, ME5
  • Links
    NCBI Gene ID: 2195
    neXtProt AC: NX_Q14517
    UniProt: Q14517

  • Chr Location
    4q35.2; chr4:186587783-186726915 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with Fat1 mouse models

Human Disease Mouse Models
      
IDs
View 3 models
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    4 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    47 phenotypes from 7 alleles in 7 genetic backgrounds
    13 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit holoprosencephaly, anophthalmia, kidney defects and perinatal lethality. Mice homozygous for a hypomorphic allele exhibit altered shoulder girdle and facial musculature, retinal defects, abnormal inner earpatterning and kidney defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000048086 VEGA Gene Model | MGI Sequence Detail 116811 C57BL/6J ±  kb
    transcript OTTMUST00000123547 VEGA | MGI Sequence Detail 14651 Not Applicable  
    polypeptide OTTMUSP00000077461 VEGA | MGI Sequence Detail 4602 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      675 from dbSNP Build 142
    • PCR
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 255
      Genomic 3
      cDNA 247
      Primer pair 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-38212, MGI:1924002, MGI:2142710
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 10
      Diseases 2
      Gene Ontology 3
      Phenotypes 16
    • Earliest
      J:37528 Skarnes WC, et al., Capturing genes encoding membrane and secreted proteins important for mouse development. Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6592-6
    • Latest
      J:263230 Helmbacher F, Tissue-specific activities of the Fat1 cadherin cooperate to control neuromuscular morphogenesis. PLoS Biol. 2018 May;16(5):e2004734

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory