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Fat1
Gene Detail
 Symbol
Name
ID
Fat1
FAT tumor suppressor homolog 1 (Drosophila)
MGI:109168
Synonyms 2310038E12Rik, Fath, mFat1
Feature Type protein coding gene
Genetic Map
Chromosome 8
24.81 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr8:44950208-45052257 bp, + strand
From NCBI annotation of GRCm38

  102050 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:66302  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Fat1

Human
homologs
Human Homolog FAT1, FAT atypical cadherin 1
NCBI Gene ID 2195
neXtProt AC  NX_Q14517
Human Synonyms  CDHF7, CDHR8, FAT, hFat1, ME5
Human Chr (Location)  4q35; chr4:186587783-186726722 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(59) : Gene trapped(55) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation exhibit holoprosencephaly, anophthalmia, kidney defects and perinatal lethality. Mice homozygous for a hypomorphic allele exhibit altered shoulder girdle and facial musculature, retinal defects, abnormal inner ear patterning and kidney defects.
 
Interactions
Fat1 interacts with 305 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process actin filament organization, cell adhesion, ...
Component cell-cell junction, cell junction, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (138)    Tissues (77)    Images (51)
Theiler Stages: 2, 3, 9, 11, 13, 14, 15, 16, 17, 19, 20, 22, 23, 24, 28
Assay TypeResults
RNA in situ 124
RT-PCR 14
cDNA source data(247)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(254) Genomic(2) cDNA(247) Primer pair(5)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000070047 (Evidence)
Entrez Gene14107 (Evidence)
UniGene27365
DFCITC1597137, TC1601153, TC1601259
DoTSDT.101384434, DT.102546021, DT.532422, DT.94216422
NIA Mouse Gene IndexU009299
Consensus CDS ProjectCCDS52547.1
International Mouse Knockout Project StatusFat1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14107 NCBI Gene Model | MGI Sequence Detail 102050 C57BL/6J ±  kb
transcript NM_001081286 RefSeq | MGI Sequence Detail 14627 Not Specified 
polypeptide NP_001074755 RefSeq | MGI Sequence Detail 4590 Not Specified 

For the selected sequences
All sequences(66) RefSeq(24) UniProt(10)
Polymorphisms PCR(2) : SNPs within 2kb(648 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002126 Cadherin
InterPro IPR020894 Cadherin conserved site
InterPro IPR015919 Cadherin-like
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR001791 Laminin G domain
Protein Ontology PR:000007350 protocadherin Fat 1
References (Earliest) J:37528 Skarnes WC, et al., Capturing genes encoding membrane and secreted proteins important for mouse development. Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6592-6
(Latest) J:199157 Caruso N, et al., Deregulation of the Protocadherin Gene FAT1 Alters Muscle Shapes: Implications for the Pathogenesis of Facioscapulohumeral Dystrophy. PLoS Genet. 2013 Jun;9(6):e1003550
All references(42)
Other
accession IDs
MGD-MRK-38212, MGI:1924002, MGI:2142710

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory