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Sirpa Gene Detail
Summary
  • Symbol
    Sirpa
  • Name
    signal-regulatory protein alpha
  • Synonyms
    Bit, CD172a, P84, Ptpns1, SHPS-1, SIRP
  • Feature Type
    protein coding gene
  • IDs
    MGI:108563
    NCBI Gene: 19261
  • Alliance
  • Transcription Start Sites
    34 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:129592835-129632228 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 63.19 cM, cytoband F3
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    410 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108563
protein coding gene Chr2:129592665-129632228 (.)
129S1/SvImJ MGP_129S1SvImJ_G0026490
protein coding gene Chr2:132999902-133038346 (+)
A/J MGP_AJ_G0026454
protein coding gene Chr2:127595552-127638188 (+)
AKR/J MGP_AKRJ_G0026429
protein coding gene Chr2:131219979-131257581 (+)
BALB/cJ MGP_BALBcJ_G0026466
protein coding gene Chr2:127851613-127890839 (+)
C3H/HeJ MGP_C3HHeJ_G0026209
protein coding gene Chr2:131732568-131773407 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026911
protein coding gene Chr2:137141171-137180419 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024288
protein coding gene Chr2:122397432-122436499 (+)
CAST/EiJ MGP_CASTEiJ_G0025670
protein coding gene Chr2:131986433-132027848 (+)
CBA/J MGP_CBAJ_G0026189
protein coding gene Chr2:142215484-142255927 (+)
DBA/2J MGP_DBA2J_G0026323
protein coding gene Chr2:126990920-127029162 (+)
FVB/NJ MGP_FVBNJ_G0026287
protein coding gene Chr2:125633363-125671294 (+)
LP/J MGP_LPJ_G0026428
protein coding gene Chr2:133251216-133290059 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026307
protein coding gene Chr2:146107659-146146178 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026966
protein coding gene Chr2:131249020-131287983 (+)
PWK/PhJ MGP_PWKPhJ_G0025406
protein coding gene Chr2:126562398-126600472 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025208
protein coding gene Chr2:130377611-130416798 (+)
WSB/EiJ MGP_WSBEiJ_G0025744
protein coding gene Chr2:132187157-132226326 (+)



Homology
more
  • Human Ortholog
    SIRPA, signal regulatory protein alpha
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SIRPA, signal regulatory protein alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BIT, CD172A, MFR, MYD-1, P84, PTPNS1, SHPS1, SIRP
  • Links
    NCBI Gene ID: 140885
    neXtProt AC: NX_P78324
    UniProt: P78324

  • Chr Location
    20p13; chr20:1894117-1939895 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 3 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    1 images
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display mild thrombocytopenia, fatty livers, decreased body weight, decreased proportion of single positive T cells, enhanced peritoneal macrophage phagocytosis and impaired Langerhans cell migration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037902 Ensembl Gene Model | MGI Sequence Detail 39394 C57BL/6J ±  kb
    transcript ENSMUST00000161620 Ensembl | MGI Sequence Detail 3824 Not Applicable  
    polypeptide ENSMUSP00000124048 Ensembl | MGI Sequence Detail 513 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • PDB
    • InterPro Domains
      IPR003597 Immunoglobulin C1-set
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
      IPR003599 Immunoglobulin subtype
      IPR013106 Immunoglobulin V-set domain
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 22
      Primer pair 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-36527, MGD-MRK-37607, MGI:107947, MGI:2139057
    References
    more
    • Summaries
      All 132
      Developmental Gene Expression 8
      Gene Ontology 16
      Phenotypes 47
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:261263 Dai H, et al., Donor SIRPalpha polymorphism modulates the innate immune response to allogeneic grafts. Sci Immunol. 2017 Jun 23;2(12)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory