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Sirpa
Gene Detail
Symbol

Name
ID
Sirpa
signal-regulatory protein alpha
MGI:108563
Synonyms
Bit, CD172a, P84, Ptpns1, SHPS-1, SIRP
Feature Type
protein coding gene
Genetic Map
Chromosome 2
63.19 cM, cytoband F3
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr2:129592835-129632228 bp, + strand
From VEGA annotation of GRCm38

  39394 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7246  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 chicken

HCOP human homology predictions: SIRPA
Protein SuperFamily: Signal-regulatory protein beta-1
Gene Tree: Sirpa

Human
homologs
SIRPA, signal-regulatory protein alpha
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 140885
neXtProt AC: NX_P78324

Human Synonyms: BIT, CD172A, MFR, MYD-1, P84, PTPNS1, SHPS1, SIRP

Human Chr (Location): 20p13; chr20:1894117-1939896 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(4) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display mild thrombocytopenia, fatty livers, decreased body weight, decreased proportion of single positive T cells, enhanced peritoneal macrophage phagocytosis and impaired Langerhans cell migration.
 
Phenotype Images(1)
Interactions
Sirpa interacts with 240 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process actin filament organization, cell-matrix adhesion, ...
Component extracellular exosome, integral component of membrane, ...
Function protein binding, protein phosphorylated amino acid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (96)    Tissues (43)    Images (33)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 90
Northern blot 4
cDNA source data(20)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) cDNA(20) Primer pair(2)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000015506 (Evidence)
Ensembl Gene Model ENSMUSG00000037902 (Evidence)
Entrez Gene 19261 (Evidence)
DFCI TC1572795, TC1593297, TC1676392
DoTS DT.101379788, DT.110682099, DT.533666, DT.94402714
NIA Mouse Gene Index U002460
PDB 2YZ1
Consensus CDS Project CCDS16729.1, CCDS50708.1, CCDS71142.1, CCDS71143.1
International Mouse Phenotyping Consortium Status Sirpa
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015506 VEGA Gene Model | MGI Sequence Detail 39394 C57BL/6J ±  kb
transcript OTTMUST00000086795 VEGA | MGI Sequence Detail 3824 Not Applicable 
polypeptide OTTMUSP00000047032 VEGA | MGI Sequence Detail 513 Not Applicable 

For the selected sequences
All sequences(107) RefSeq(17) UniProt(7)
Polymorphisms
All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(405 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003597 Immunoglobulin C1-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR013106 Immunoglobulin V-set
Protein Ontology PR:000001968 tyrosine-protein phosphatase non-receptor type substrate 1
References
(Earliest) J:36295 Ohnishi H, et al., Activation of protein-tyrosine phosphatase SH-PTP2 by a tyrosine-based activation motif of a novel brain molecule. J Biol Chem. 1996 Oct 11;271(41):25569-74
(Latest) J:204546 Koskinen C, et al., Lack of CD47 impairs bone cell differentiation and results in an osteopenic phenotype in vivo due to impaired signal regulatory protein alpha (SIRPalpha) signaling. J Biol Chem. 2013 Oct 11;288(41):29333-44
All references(96)
Other
accession IDs
MGD-MRK-36527, MGD-MRK-37607, MGI:107947, MGI:2139057

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory