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Sirpa Gene Detail
Summary
  • Symbol
    Sirpa
  • Name
    signal-regulatory protein alpha
  • Synonyms
    Bit, CD172a, P84, Ptpns1, SHPS-1, SIRP
  • Feature Type
    protein coding gene
  • IDs
    MGI:108563
    NCBI Gene: 19261
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr2:129592835-129632228 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      39394 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 63.19 cM, cytoband F3
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    SIRPA, signal regulatory protein alpha
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SIRPA, signal regulatory protein alpha
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BIT, CD172A, MFR, MYD-1, P84, PTPNS1, SHPS1, SIRP
  • Links
    NCBI Gene ID: 140885
    neXtProt AC: NX_P78324
    UniProt: P78324

  • Chr Location
    20p13; chr20:1894117-1939895 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 3 alleles in 4 genetic backgrounds
    1 phenotype from multigenic genotypes
    1 images
    45 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display mild thrombocytopenia, fatty livers, decreased body weight, decreased proportion of single positive T cells, enhanced peritoneal macrophage phagocytosis and impaired Langerhans cell migration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000015506 VEGA Gene Model | MGI Sequence Detail 39394 C57BL/6J ±  kb
    transcript OTTMUST00000086795 VEGA | MGI Sequence Detail 3824 Not Applicable  
    polypeptide OTTMUSP00000047032 VEGA | MGI Sequence Detail 513 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      410 from dbSNP Build 142
    • PCR
    • RFLP
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • PDB
    • InterPro Domains
      IPR003597 Immunoglobulin C1-set
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
      IPR003599 Immunoglobulin subtype
      IPR013106 Immunoglobulin V-set domain
    Molecular
    Reagents
    less
    • All nucleic 22
      cDNA 20
      Primer pair 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-36527, MGD-MRK-37607, MGI:107947, MGI:2139057
    References
    more
    • Summaries
      All 124
      Developmental Gene Expression 8
      Gene Ontology 9
      Phenotypes 45
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:254861 Hu Z, et al., CCR7 Modulates the Generation of Thymic Regulatory T Cells by Altering the Composition of the Thymic Dendritic Cell Compartment. Cell Rep. 2017 Oct 3;21(1):168-180

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory