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Sirpa Gene Detail
Summary
  • Symbol
    Sirpa
  • Name
    signal-regulatory protein alpha
  • Synonyms
    Bit, CD172a, Idd13.2, P84, Ptpns1, SHPS-1, SIRP
  • Feature Type
    protein coding gene
  • IDs
    MGI:108563
    NCBI Gene: 19261
  • Alliance
    gene page
  • Transcription Start Sites
    51 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:129434755-129474148 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 63.19 cM, cytoband F3
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1199 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108563
 protein coding gene Chr2:129432962-129474148 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026490
 protein coding gene Chr2:132999902-133038346 (+)
A/J MGP_AJ_G0026454
 protein coding gene Chr2:127595552-127638188 (+)
AKR/J MGP_AKRJ_G0026429
 protein coding gene Chr2:131219979-131257581 (+)
BALB/cJ MGP_BALBcJ_G0026466
 protein coding gene Chr2:127851613-127890839 (+)
C3H/HeJ MGP_C3HHeJ_G0026209
 protein coding gene Chr2:131732568-131773407 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026911
 protein coding gene Chr2:137141171-137180419 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024288
 protein coding gene Chr2:122397432-122436499 (+)
CAST/EiJ MGP_CASTEiJ_G0025670
 protein coding gene Chr2:131986433-132027848 (+)
CBA/J MGP_CBAJ_G0026189
 protein coding gene Chr2:142215484-142255927 (+)
DBA/2J MGP_DBA2J_G0026323
 protein coding gene Chr2:126990920-127029162 (+)
FVB/NJ MGP_FVBNJ_G0026287
 protein coding gene Chr2:125633363-125671294 (+)
LP/J MGP_LPJ_G0026428
 protein coding gene Chr2:133251216-133290059 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026307
 protein coding gene Chr2:146107659-146146178 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026966
 protein coding gene Chr2:131249020-131287983 (+)
PWK/PhJ MGP_PWKPhJ_G0025406
 protein coding gene Chr2:126562398-126600472 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025208
 protein coding gene Chr2:130377611-130416798 (+)
WSB/EiJ MGP_WSBEiJ_G0025744
 protein coding gene Chr2:132187157-132226326 (+)



Homology
more
  • Human Ortholog
    SIRPA, signal regulatory protein alpha
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SIRPA, signal regulatory protein alpha
  • Synonyms
    BIT, CD172A, MFR, MYD-1, MYD1, P84, PTPNS1, SHPS1, SIRP
  • Links
    NCBI Gene ID: 140885
    UniProt: P78324

  • Chr Location
    20p13; chr20:1894167-1940592 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 3 alleles in 4 genetic backgrounds
    1 images
    80 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display mild thrombocytopenia, fatty livers, decreased body weight, decreased proportion of single positive T cells, enhanced peritoneal macrophage phagocytosis and impaired Langerhans cell migration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    69
  • GO References
    17
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    864
  • Tissues
    74
  • cDNA Data
    23
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037902 Ensembl Gene Model | MGI Sequence Detail 39394 C57BL/6J ±  kb
    transcript ENSMUST00000049262 Ensembl | MGI Sequence Detail 3644 Not Applicable  
    polypeptide ENSMUSP00000049022 Ensembl | MGI Sequence Detail 513 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000001968 tyrosine-protein phosphatase non-receptor type substrate 1
      (term hierarchy)
    • PDB
      2YZ1
    • InterPro Domains
      IPR003597 Immunoglobulin C1-set
      IPR051755 Immunoglobulin-like Cell Surface Receptor
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR003006 Immunoglobulin/major histocompatibility complex, conserved site
      IPR003599 Immunoglobulin subtype
      IPR013106 Immunoglobulin V-set domain
    • GlyGen
      P97797 22 sites, 38 N-linked glycans (15 sites), 1 O-linked glycan (4 sites)
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 23
      Primer pair 4

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-36527, MGD-MRK-37607, MGI:107947, MGI:2139057
    References
    more
    • Summaries
      All 183
      Developmental Gene Expression 11
      Gene Ontology 17
      Phenotypes 80
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:360074 Jia Y, et al., Targeting SLC22A5 fosters mitophagy inhibition-mediated macrophage immunity against septic acute kidney injury upon CD47-SIRPalpha axis blockade. Heliyon. 2024 Apr 15;10(7):e26791
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/30/2025
    MGI 6.24     		The Jackson Laboratory