Kif1b
Gene Detail

Symbol Name ID

Kif1b kinesin family member 1B MGI:108426

Synonyms

A530096N05Rik, D4Mil1e, Kif1b alpha, Kif1b beta, KIF1Bp130, KIF1Bp204, mKIAA0591, N-3 kinesin

Feature Type

protein coding gene

Genetic Map

Chromosome 4

79.05 cM, cytoband E
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr4:149176319-149307693 bp, - strand From VEGA annotation of GRCm38   131375 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:99835  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Protein SuperFamily: kinesin protein, Kif1A/Kif1B types
Gene Tree: Kif1b

Human homologs

Human Homolog		KIF1B, kinesin family member 1B
NCBI Gene ID		23095
neXtProt AC		NX_O60333
Human Synonyms		CMT2, CMT2A, CMT2A1, HMSNII, KLP, NBLST1
Human Chr (Location)		1p36.2; chr1:10270764-10441661 (+)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human KIF1B

Alleles and phenotypes

All alleles(51) : Targeted(3) Gene trapped(48)
 

Homozygotes for a targeted null mutation exhibit reduced brain size, elevated pain threshold, and neonatal death from apnea. Heterozygotes exhibit impaired synaptic vesicle precursor transport and progressive muscle weakness.

 
Human Diseases Modeled Using Mouse Kif1b (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	anterograde axon cargo transport, ATP catabolic process, ...
Component	cytoplasm, cytoplasmic vesicle, ...
Function	ATPase activity, ATP binding, ...

External Resources: FuncBase

Expression

Literature Summary: (15 records)
Data Summary: Results (307)    Tissues (91)    Images (44)
Theiler Stages: 15, 17, 18, 19, 22, 23, 26, 28

Assay Type	Results
RNA in situ	274
Northern blot	15
RT-PCR	18

cDNA source data(26)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(36) Genomic(4) cDNA(29) Primer pair(3)
Microarray probesets(14)

Other database links

VEGA Gene Model	OTTMUSG00000010170 (Evidence)
Ensembl Gene Model	ENSMUSG00000063077 (Evidence)
Entrez Gene	16561 (Evidence)
DFCI	TC1577322, TC1581054, TC1598014, TC1598149, TC1607671, TC1611617, TC1647541, TC1688579
DoTS	DT.101168789, DT.101241064, DT.101264796, DT.110803531, DT.110803540, DT.87069547, DT.87069549, DT.91581921, DT.94159649, DT.97370963
NIA Mouse Gene Index	U025798
Consensus CDS Project	CCDS18956.1, CCDS18957.1
International Mouse Knockout Project Status	Kif1b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000010170	VEGA Gene Model | MGI Sequence Detail	131375	C57BL/6J
transcript	OTTMUST00000023642	VEGA | MGI Sequence Detail	10233	Not Applicable
polypeptide	OTTMUSP00000010804	VEGA | MGI Sequence Detail	1816	Not Applicable

All sequences(97) RefSeq(4) UniProt(8)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(699 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000253	Forkhead-associated (FHA) domain
InterPro	IPR022164	Kinesin-like
InterPro	IPR001752	Kinesin, motor domain
InterPro	IPR019821	Kinesin, motor region, conserved site
InterPro	IPR022140	Kinesin protein 1B
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR008984	SMAD/FHA domain
Protein Ontology	PR:000009296	kinesin-like protein KIF1B

References

(Earliest) J:113711 Matthews RH, et al., Biphasic kinetic plots and specific analogs distinguishing and describing amino acid transport sites in S37 ascites tumor cells. Biochim Biophys Acta. 1975 Jun 25;394(2):182-92
(Latest) J:193641 Nakano Y, et al., A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. PLoS Genet. 2012;8(10):e1002966
All references(61)

Other accession IDs

MGD-MRK-35098, MGD-MRK-37469, MGI:106641, MGI:2140281, MGI:2140318, MGI:2442923