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Kif1a
Gene Detail
 Symbol
Name
ID
Kif1a
kinesin family member 1A
MGI:108391
Synonyms ATSV, C630002N23Rik, Kns1, LOC381283, N-3 kinesin
Feature Type protein coding gene
Genetic Map
Chromosome 1
46.74 cM, cytoband E1-E2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:93015464-93101951 bp, - strand
From VEGA annotation of GRCm38

  86488 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:99729  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: kinesin protein, Kif1A/Kif1B types
Gene Tree: Kif1a

Human
homologs
Human Homolog KIF1A, kinesin family member 1A
NCBI Gene ID 547
neXtProt AC  NX_Q12756
Human Synonyms  ATSV, C2orf20, HSN2C, MRD9, SPG30, UNC104
Human Chr (Location)  2q37.3; chr2:240713764-240820308 (-)  GRCh38
Disease Associations  (3) Diseases Associated with Human KIF1A
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Gene trapped(1) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Most mice homozygous for a null allele die within a day of birth, exhibiting reduced birth weight, hypoactivity, motor and sensory deficits, decreased synaptic vesicle precursor transport, and significant neuronal degeneration and neuronal cell death in the central nervous system.
 
Phenotype Images(3)
Interactions
Kif1a interacts with 301 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process ATP catabolic process, cytoskeleton-dependent intracellular transport, ...
Component cytoplasm, cytoskeleton, ...
Function ATPase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (187)    Tissues (44)    Images (25)
Theiler Stages: 17, 23
Assay TypeResults
RNA in situ 187
cDNA source data(334)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(334) cDNA(334)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000048636 (Evidence)
Ensembl Gene ModelENSMUSG00000014602 (Evidence)
Entrez Gene16560 (Evidence)
UniGene276408
DFCITC1574064, TC1585081, TC1641825
DoTSDT.101262718, DT.101394353, DT.102557428, DT.529682
NIA Mouse Gene IndexU021608
PDB1I5S, 1I6I, 1VFV, 1VFW, 1VFX, 1VFZ, 2HXF, 2HXH, 2ZFI, 2ZFJ, 2ZFK, 2ZFL, 2ZFM, 1IA0
Consensus CDS ProjectCCDS48326.1, CCDS48327.1
International Mouse Knockout Project StatusKif1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048636 VEGA Gene Model | MGI Sequence Detail 86488 C57BL/6J ±  kb
transcript OTTMUST00000124564 VEGA | MGI Sequence Detail 6141 Not Applicable 
polypeptide OTTMUSP00000067752 VEGA | MGI Sequence Detail 1791 Not Applicable 

For the selected sequences
All sequences(86) RefSeq(22) UniProt(11)
Polymorphisms SNPs within 2kb(549 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000253 Forkhead-associated (FHA) domain
InterPro IPR022164 Kinesin-like
InterPro IPR001752 Kinesin, motor domain
InterPro IPR019821 Kinesin, motor region, conserved site
InterPro IPR022140 Kinesin protein 1B
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR008984 SMAD/FHA domain
Protein Ontology PR:000009295 kinesin-like protein KIF1A
References (Earliest) J:3448 Aizawa H, et al., Kinesin family in murine central nervous system. J Cell Biol. 1992 Dec;119(5):1287-96
(Latest) J:195317 Blehm BH, et al., In vivo optical trapping indicates kinesin's stall force is reduced by dynein during intracellular transport. Proc Natl Acad Sci U S A. 2013 Feb 26;110(9):3381-6
All references(39)
Other
accession IDs
MGD-MRK-11590, MGD-MRK-37431, MGI:2686472

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory