Kif1a
Gene Detail

Symbol Name ID

Kif1a kinesin family member 1A MGI:108391

Synonyms

ATSV, C630002N23Rik, Kns1, LOC381283, N-3 kinesin

Feature Type

protein coding gene

Genetic Map

Chromosome 1

46.74 cM, cytoband E1-E2
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr1:93015456-93101865 bp, - strand From NCBI annotation of GRCm38   86410 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:99729  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: kinesin protein, Kif1A/Kif1B types
Gene Tree: Kif1a

Human homologs

Human Homolog		KIF1A, kinesin family member 1A
NCBI Gene ID		547
neXtProt AC		NX_Q12756
Human Synonyms		ATSV, C2orf20, HSN2C, MRD9, SPG30, UNC104
Human Chr (Location)		2q37.3; chr2:241653181-241759725 (-)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human KIF1A

Alleles and phenotypes

All alleles(2) : Targeted(1) Gene trapped(1)
 

Most mice homozygous for a null allele die within a day of birth, exhibiting reduced birth weight, hypoactivity, motor and sensory deficits, decreased synaptic vesicle precursor transport, and significant neuronal degeneration and neuronal cell death in the central nervous system.

 
Phenotype Images(3)

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	microtubule-based movement
Component	cytoplasm, cytoskeleton, ...
Function	ATP binding, microtubule binding, ...

External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (187)    Tissues (44)    Images (25)
Theiler Stages: 17, 23

Assay Type	Results
RNA in situ	187

cDNA source data(334)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(334) cDNA(334)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000014602 (Evidence)
Entrez Gene	16560 (Evidence)
UniGene	276408
DFCI	TC1574064, TC1585081, TC1641825
DoTS	DT.101262718, DT.101394353, DT.102557428, DT.529682
NIA Mouse Gene Index	U021608
PDB	1I5S, 1I6I, 1VFV, 1VFW, 1VFX, 1VFZ, 2HXF, 2HXH, 2ZFI, 2ZFJ, 2ZFK, 2ZFL, 2ZFM, 1IA0
Consensus CDS Project	CCDS48326.1, CCDS48327.1
International Mouse Knockout Project Status	Kif1a

Sequences

Length	Strain/Species
genomic	16560	NCBI Gene Model | MGI Sequence Detail	86410	C57BL/6J
transcript	NM_008440	RefSeq | MGI Sequence Detail	8257	C57BL/6
polypeptide	P33173	UniProt | EBI | MGI Sequence Detail	1695	Not Applicable

All sequences(46) RefSeq(4) UniProt(11)

Polymorphisms

SNPs(492 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000253	Forkhead-associated (FHA) domain
InterPro	IPR022164	Kinesin-like
InterPro	IPR001752	Kinesin, motor domain
InterPro	IPR019821	Kinesin, motor region, conserved site
InterPro	IPR022140	Kinesin protein 1B
InterPro	IPR001849	Pleckstrin homology domain
InterPro	IPR011993	Pleckstrin homology-like domain
InterPro	IPR008984	SMAD/FHA domain
Protein Ontology	PR:000009295	kinesin-like protein KIF1A

Graphical View of Protein Domain Structure

References

(Earliest) J:3448 Aizawa H, et al., Kinesin family in murine central nervous system. J Cell Biol. 1992 Dec;119(5):1287-96
(Latest) J:182702 Kondo M, et al., Motor protein KIF1A is essential for hippocampal synaptogenesis and learning enhancement in an enriched environment. Neuron. 2012 Feb 23;73(4):743-57
All references(37)

Other accession IDs

MGD-MRK-11590, MGD-MRK-37431, MGI:2686472