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Dhx9 Gene Detail
Summary
  • Symbol
    Dhx9
  • Name
    DEAH (Asp-Glu-Ala-His) box polypeptide 9
  • Synonyms
    Ddx9, leukophysin, NDHII, NDH II, nuclear DNA helicase II, RHA, RNA helicase
  • Feature Type
    protein coding gene
  • IDs
    MGI:108177
    NCBI Gene: 13211
  • Gene Overview
    MyGene.info: DHX9
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:153455758-153487660 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 65.37 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    131 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108177
protein coding gene Chr1:153455756-153487689 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016597
protein coding gene Chr1:158279406-158312420 (-)
A/J MGP_AJ_G0016579
protein coding gene Chr1:151901694-151933596 (-)
AKR/J MGP_AKRJ_G0016544
protein coding gene Chr1:156605696-156637598 (-)
BALB/cJ MGP_BALBcJ_G0016539
protein coding gene Chr1:152451992-152483895 (-)
C3H/HeJ MGP_C3HHeJ_G0016364
protein coding gene Chr1:156703624-156735526 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017000
protein coding gene Chr1:163754437-163787534 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014709
protein coding gene Chr1:144193948-144230026 (-)
CAST/EiJ MGP_CASTEiJ_G0015943
protein coding gene Chr1:156218512-156258981 (-)
CBA/J MGP_CBAJ_G0016338
protein coding gene Chr1:169513486-169545397 (-)
DBA/2J MGP_DBA2J_G0016444
protein coding gene Chr1:150924285-150955975 (-)
FVB/NJ MGP_FVBNJ_G0016442
protein coding gene Chr1:149388588-149420554 (-)
LP/J MGP_LPJ_G0016515
protein coding gene Chr1:159404611-159436546 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016468
protein coding gene Chr1:177144504-177177874 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017036
protein coding gene Chr1:156377168-156409103 (-)
PWK/PhJ MGP_PWKPhJ_G0015729
protein coding gene Chr1:149960840-149993449 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015516
protein coding gene Chr1:155175423-155207358 (-)
WSB/EiJ MGP_WSBEiJ_G0016006
protein coding gene Chr1:156452225-156485153 (-)



Homology
more
  • Human Ortholog
    DHX9, DExH-box helicase 9
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DHX9, DExH-box helicase 9
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DDX9, LKP, NDH2, NDHII, RHA
  • Links
    NCBI Gene ID: 1660
    neXtProt AC: NX_Q08211
    UniProt: Q08211

  • Chr Location
    1q25.3; chr1:182839304-182887982 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1039
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: DHX9
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes die in embryonic stages with massive apoptotic cell death in embryonic ectodermal cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000042699 Ensembl Gene Model | MGI Sequence Detail 31903 C57BL/6J ±  kb
    transcript ENSMUST00000042141 Ensembl | MGI Sequence Detail 4616 Not Applicable  
    polypeptide ENSMUSP00000038135 Ensembl | MGI Sequence Detail 1384 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 74
      Genomic 3
      cDNA 70
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-37216, MGI:2138215
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 5
      Gene Ontology 12
      Phenotypes 12
    • Earliest
      J:45144 Miazek A, et al., Identification of a T cell lineage-specific RNA/DNA helicase and its cell surface expression during intrathymic education of alphabeta and gammadelta T cells. Eur J Immunol. 1997 Dec;27(12):3269-82
    • Latest
      J:265915 Ng YC, et al., A DNA-sensing-independent role of a nuclear RNA helicase, DHX9, in stimulation of NF-kappaB-mediated innate immunity against DNA virus infection. Nucleic Acids Res. 2018 Sep 28;46(17):9011-9026

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory