About   Help   FAQ
Dhx9
Gene Detail
Symbol

Name
ID
Dhx9
DEAH (Asp-Glu-Ala-His) box polypeptide 9
MGI:108177
Synonyms
Ddx9, leukophysin, NDHII, NDH II, nuclear DNA helicase II, RHA, RNA helicase
Feature Type
protein coding gene
Genetic Map
Chromosome 1
65.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr1:153455758-153487658 bp, - strand
From VEGA annotation of GRCm38

  31901 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1039  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Gene Tree: Dhx9

Human
homologs
Human Homolog DHX9, DEAH (Asp-Glu-Ala-His) box helicase 9
NCBI Gene ID 1660
neXtProt AC  NX_Q08211
Human Synonyms  DDX9, LKP, NDH2, NDHII, RHA
Human Chr (Location)  1q25; chr1:182839304-182887982 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(71) : Gene trapped(67) Targeted(3) Transposon induced(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes die in embryonic stages with massive apoptotic cell death in embryonic ectodermal cells.
 
Interactions
Dhx9 interacts with 128 markers (Mir16-1, Mir19a, Mir19b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process cellular response to heat, circadian rhythm, ...
Component centrosome, CRD-mediated mRNA stability complex, ...
Function ATP binding, ATP-dependent helicase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (356)    Tissues (102)    Images (30)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 354
RT-PCR 2
cDNA source data(69)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(73) Genomic(3) cDNA(69) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000049714 (Evidence)
Ensembl Gene ModelENSMUSG00000042699 (Evidence)
Entrez Gene13211 (Evidence)
UniGene20000
DFCITC1581281, TC1593196, TC1622599, TC1636046, TC1641471, TC1651126
DoTSDT.101378375, DT.530612, DT.91346283, DT.94167854, DT.94326167
NIA Mouse Gene IndexU021902
EC3.6.4.13
PDB1UIL, 1WHQ, 2RS6, 2RS7
International Mouse Knockout Project StatusDhx9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049714 VEGA Gene Model | MGI Sequence Detail 31901 C57BL/6J ±  kb
transcript OTTMUST00000126626 VEGA | MGI Sequence Detail 4561 Not Applicable 
polypeptide OTTMUSP00000068448 VEGA | MGI Sequence Detail 1383 Not Applicable 

For the selected sequences
All sequences(67) RefSeq(4) UniProt(11)
Polymorphisms
RFLP(1) : SNPs within 2kb(131 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002464 DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
InterPro IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal
InterPro IPR011709 Domain of unknown function DUF1605
InterPro IPR014720 Double-stranded RNA-binding-like domain
InterPro IPR007502 Helicase-associated domain
InterPro IPR001650 Helicase, C-terminal
InterPro IPR014001 Helicase, superfamily 1/2, ATP-binding domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000006474 ATP-dependent RNA helicase A
References
(Earliest) J:45144 Miazek A, et al., Identification of a T cell lineage-specific RNA/DNA helicase and its cell surface expression during intrathymic education of alphabeta and gammadelta T cells. Eur J Immunol. 1997 Dec;27(12):3269-82
(Latest) J:206774 Wolstenholme JT, et al., Sexual differentiation in the developing mouse brain: contributions of sex chromosome genes. Genes Brain Behav. 2013 Mar;12(2):166-80
All references(51)
Other
accession IDs
MGD-MRK-37216, MGI:2138215

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/21/2014
MGI 5.20
The Jackson Laboratory