Dhx9
Gene Detail

Symbol Name ID

Dhx9 DEAH (Asp-Glu-Ala-His) box polypeptide 9 MGI:108177

Synonyms

Ddx9, leukophysin, NDHII, NDH II, nuclear DNA helicase II, RHA, RNA helicase

Feature Type

protein coding gene

Genetic Map

Chromosome 1

65.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr1:153455758-153487660 bp, - strand From NCBI annotation of GRCm38   31903 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1039  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 zebrafish

Gene Tree: Dhx9

Human homologs

Human Homolog		DHX9, DEAH (Asp-Glu-Ala-His) box polypeptide 9
NCBI Gene ID		1660
neXtProt AC		NX_Q08211
Human Synonyms		DDX9, LKP, NDH2, NDHII, RHA
Human Chr (Location)		1q25; chr1:182808439-182857117 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(70) : Targeted(3) Gene trapped(67)
 

Homozygotes die in embryonic stages with massive apoptotic cell death in embryonic ectodermal cells.

 

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	cellular response to heat, circadian rhythm, ...
Component	centrosome, CRD-mediated mRNA stability complex, ...
Function	ATP binding, ATP-dependent helicase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (307)    Tissues (53)    Images (28)
Theiler Stages: 21, 23, 28

Assay Type	Results
RNA in situ	305
RT-PCR	2

cDNA source data(68)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(72) Genomic(3) cDNA(68) Primer pair(1)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000042699 (Evidence)
Entrez Gene	13211 (Evidence)
UniGene	20000
DFCI	TC1581281, TC1593196, TC1622599, TC1636046, TC1641471, TC1651126
DoTS	DT.101378375, DT.530612, DT.91346283, DT.94167854, DT.94326167
NIA Mouse Gene Index	U021902
EC	3.6.4.13
PDB	1UIL, 1WHQ, 2RS6, 2RS7
International Mouse Knockout Project Status	Dhx9

Sequences

Length	Strain/Species
genomic	13211	NCBI Gene Model | MGI Sequence Detail	31903	C57BL/6J
transcript	NM_007842	RefSeq | MGI Sequence Detail	4623	C57BL/6
polypeptide	O70133	UniProt | EBI | MGI Sequence Detail	1380	Not Applicable

All sequences(46) RefSeq(2) UniProt(6)

Polymorphisms

RFLP(1) : SNPs(117 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002464	DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
InterPro	IPR011545	DNA/RNA helicase, DEAD/DEAH box type, N-terminal
InterPro	IPR011709	Domain of unknown function DUF1605
InterPro	IPR001159	Double-stranded RNA-binding
InterPro	IPR014720	Double-stranded RNA-binding-like
InterPro	IPR007502	Helicase-associated domain
InterPro	IPR001650	Helicase, C-terminal
InterPro	IPR014001	Helicase, superfamily 1/2, ATP-binding domain
Protein Ontology	PR:000006474	ATP-dependent RNA helicase A

Graphical View of Protein Domain Structure

References

(Earliest) J:45144 Miazek A, et al., Identification of a T cell lineage-specific RNA/DNA helicase and its cell surface expression during intrathymic education of alphabeta and gammadelta T cells. Eur J Immunol. 1997 Dec;27(12):3269-82
(Latest) J:185950 Padmanabhan K, et al., Feedback regulation of transcriptional termination by the mammalian circadian clock PERIOD complex. Science. 2012 Aug 3;337(6094):599-602
All references(46)

Other accession IDs

MGD-MRK-37216, MGI:2138215