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Dhx9
Gene Detail
 Symbol
Name
ID
Dhx9
DEAH (Asp-Glu-Ala-His) box polypeptide 9
MGI:108177
Synonyms Ddx9, leukophysin, NDHII, NDH II, nuclear DNA helicase II, RHA, RNA helicase
Feature Type protein coding gene
Genetic Map
Chromosome 1
65.37 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr1:153455758-153487660 bp, - strand
From NCBI annotation of GRCm38

  31903 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1039  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 zebrafish

Gene Tree: Dhx9

Human
homologs
Human Homolog DHX9, DEAH (Asp-Glu-Ala-His) box helicase 9
NCBI Gene ID 1660
neXtProt AC  NX_Q08211
Human Synonyms  DDX9, LKP, NDH2, NDHII, RHA
Human Chr (Location)  1q25; chr1:182839304-182887982 (+)  GRCh38
Alleles
and
phenotypes
All alleles(70) : Targeted(3) Gene trapped(67)
 
Homozygotes die in embryonic stages with massive apoptotic cell death in embryonic ectodermal cells.
 
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process cellular response to heat, circadian rhythm, ...
Component centrosome, CRD-mediated mRNA stability complex, ...
Function ATP binding, ATP-dependent helicase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (356)    Tissues (102)    Images (30)
Theiler Stages: 21, 23, 26, 28
Assay TypeResults
RNA in situ 354
RT-PCR 2
cDNA source data(69)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(73) Genomic(3) cDNA(69) Primer pair(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000042699 (Evidence)
Entrez Gene13211 (Evidence)
UniGene20000
DFCITC1581281, TC1593196, TC1622599, TC1636046, TC1641471, TC1651126
DoTSDT.101378375, DT.530612, DT.91346283, DT.94167854, DT.94326167
NIA Mouse Gene IndexU021902
EC3.6.4.13
PDB1UIL, 1WHQ, 2RS6, 2RS7
International Mouse Knockout Project StatusDhx9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13211 NCBI Gene Model | MGI Sequence Detail 31903 C57BL/6J ±  kb
transcript NM_007842 RefSeq | MGI Sequence Detail 4623 C57BL/6 
polypeptide O70133 UniProt | EBI | MGI Sequence Detail 1380 Not Applicable 

For the selected sequences
All sequences(49) RefSeq(4) UniProt(6)
Polymorphisms RFLP(1) : SNPs within 2kb(131 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002464 DNA/RNA helicase, ATP-dependent, DEAH-box type, conserved site
InterPro IPR011545 DNA/RNA helicase, DEAD/DEAH box type, N-terminal
InterPro IPR011709 Domain of unknown function DUF1605
InterPro IPR014720 Double-stranded RNA-binding-like domain
InterPro IPR007502 Helicase-associated domain
InterPro IPR001650 Helicase, C-terminal
InterPro IPR014001 Helicase, superfamily 1/2, ATP-binding domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000006474 ATP-dependent RNA helicase A
Graphical View of Protein Domain Structure
References (Earliest) J:45144 Miazek A, et al., Identification of a T cell lineage-specific RNA/DNA helicase and its cell surface expression during intrathymic education of alphabeta and gammadelta T cells. Eur J Immunol. 1997 Dec;27(12):3269-82
(Latest) J:185950 Padmanabhan K, et al., Feedback regulation of transcriptional termination by the mammalian circadian clock PERIOD complex. Science. 2012 Aug 3;337(6094):599-602
All references(47)
Other
accession IDs
MGD-MRK-37216, MGI:2138215

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory