About   Help   FAQ
Cxcl1 Gene Detail
Summary
  • Symbol
    Cxcl1
  • Name
    chemokine (C-X-C motif) ligand 1
  • Synonyms
    Fsp, Gro1, KC, KC/GRO-alpha, Mgsa, N51, Scyb1
  • Feature Type
    protein coding gene
  • IDs
    MGI:108068
    NCBI Gene: 14825
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:90891241-90893115 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 44.78 cM, cytoband E-F
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    67 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108068
protein coding gene Chr5:90891241-90893121 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029731
protein coding gene Chr5:91983100-91984968 (+)
A/J MGP_AJ_G0029697
protein coding gene Chr5:88356388-88358262 (+)
AKR/J MGP_AKRJ_G0029643
protein coding gene Chr5:91216449-91218323 (+)
BALB/cJ MGP_BALBcJ_G0029707
protein coding gene Chr5:89257869-89259743 (+)
C3H/HeJ MGP_C3HHeJ_G0029430
protein coding gene Chr5:91641775-91643649 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030161
protein coding gene Chr5:95644814-95646688 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027397
protein coding gene Chr5:84045886-84047719 (+)
CAST/EiJ MGP_CASTEiJ_G0028840
protein coding gene Chr5:91002167-91004041 (+)
CBA/J MGP_CBAJ_G0029400
protein coding gene Chr5:98941641-98943515 (+)
DBA/2J MGP_DBA2J_G0029544
protein coding gene Chr5:88431001-88432875 (+)
FVB/NJ MGP_FVBNJ_G0029503
protein coding gene Chr5:87278729-87280603 (+)
LP/J MGP_LPJ_G0029632
protein coding gene Chr5:92363337-92365205 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029532
protein coding gene Chr5:103911598-103913472 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030195
protein coding gene Chr5:90767517-90769385 (+)
PWK/PhJ MGP_PWKPhJ_G0028559
protein coding gene Chr5:87480527-87482359 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028394
protein coding gene Chr5:90164026-90165859 (+)
WSB/EiJ MGP_WSBEiJ_G0028919
protein coding gene Chr5:91212779-91214647 (+)



Homology
more
  • Human Ortholog
    CXCL2, C-X-C motif chemokine ligand 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    CXCL2, C-X-C motif chemokine ligand 2
    Orthology source: HomoloGene
  • Synonyms
    CINC-2a, GRO2, GROb, MGSA-b, MIP2, MIP-2a, MIP2A, SCYB2
  • Links
    NCBI Gene ID: 2920
    neXtProt AC: NX_P19875
    UniProt: P19875

  • Chr Location
    4q13.3; chr4:74097035-74099280 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from multigenic genotypes
    20 phenotype references
Targeted mutations in this gene when combine with targeted mutation of Ldlr decreases susceptibility to atherosclerotic lesions.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000029380 Ensembl Gene Model | MGI Sequence Detail 1875 C57BL/6J ±  kb
transcript ENSMUST00000031327 Ensembl | MGI Sequence Detail 953 Not Applicable  
polypeptide ENSMUSP00000031327 Ensembl | MGI Sequence Detail 96 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • InterPro Domains
    IPR001811 Chemokine interleukin-8-like domain
    IPR036048 Chemokine interleukin-8-like superfamily
    IPR001089 CXC chemokine
    IPR018048 CXC chemokine, conserved site
    IPR033899 CXC Chemokine domain
Molecular
Reagents
less
  • All nucleic 27
    cDNA 22
    Primer pair 4
    Other 1

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-12226, MGD-MRK-37105, MGD-MRK-9878
References
more
  • Summaries
    All 154
    Developmental Gene Expression 16
    Gene Ontology 14
    Phenotypes 20
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:264828 Grist JJ, et al., Induced CNS expression of CXCL1 augments neurologic disease in a murine model of multiple sclerosis via enhanced neutrophil recruitment. Eur J Immunol. 2018 Jul;48(7):1199-1210

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/06/2018
MGI 6.13
The Jackson Laboratory