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Cxcl1 Gene Detail
Summary
  • Symbol
    Cxcl1
  • Name
    C-X-C motif chemokine ligand 1
  • Synonyms
    Fsp, Gro1, KC, KC/GRO-alpha, Mgsa, N51, Scyb1
  • Feature Type
    protein coding gene
  • IDs
    MGI:108068
    NCBI Gene: 14825
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:91039100-91040974 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 5, 44.78 cM, cytoband E-F
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    67 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108068
protein coding gene Chr5:91039100-91040980 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029731
protein coding gene Chr5:91983100-91984968 (+)
A/J MGP_AJ_G0029697
protein coding gene Chr5:88356388-88358262 (+)
AKR/J MGP_AKRJ_G0029643
protein coding gene Chr5:91216449-91218323 (+)
BALB/cJ MGP_BALBcJ_G0029707
protein coding gene Chr5:89257869-89259743 (+)
C3H/HeJ MGP_C3HHeJ_G0029430
protein coding gene Chr5:91641775-91643649 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030161
protein coding gene Chr5:95644814-95646688 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027397
protein coding gene Chr5:84045886-84047719 (+)
CAST/EiJ MGP_CASTEiJ_G0028840
protein coding gene Chr5:91002167-91004041 (+)
CBA/J MGP_CBAJ_G0029400
protein coding gene Chr5:98941641-98943515 (+)
DBA/2J MGP_DBA2J_G0029544
protein coding gene Chr5:88431001-88432875 (+)
FVB/NJ MGP_FVBNJ_G0029503
protein coding gene Chr5:87278729-87280603 (+)
LP/J MGP_LPJ_G0029632
protein coding gene Chr5:92363337-92365205 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029532
protein coding gene Chr5:103911598-103913472 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030195
protein coding gene Chr5:90767517-90769385 (+)
PWK/PhJ MGP_PWKPhJ_G0028559
protein coding gene Chr5:87480527-87482359 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028394
protein coding gene Chr5:90164026-90165859 (+)
WSB/EiJ MGP_WSBEiJ_G0028919
protein coding gene Chr5:91212779-91214647 (+)



Homology
more
  • Human Ortholog
    CXCL1, C-X-C motif chemokine ligand 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CXCL1, C-X-C motif chemokine ligand 1
  • Synonyms
    FSP, GRO1, GROa, MGSA, MGSA-a, NAP-3, SCYB1
  • Links
    NCBI Gene ID: 2919
    neXtProt AC: NX_P09341
    UniProt: P09341

  • Chr Location
    4q13.3; chr4:73869393-73871308 (+)  GRCh38

  • Human Ortholog
    CXCL2, C-X-C motif chemokine ligand 2
  • Synonyms
    CINC-2a, GRO2, GROb, MGSA-b, MIP2, MIP-2a, MIP2A, SCYB2
  • Links
    NCBI Gene ID: 2920
    neXtProt AC: NX_P19875
    UniProt: P19875

  • Chr Location
    4q13.3; chr4:74097040-74099196 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted mutations in this gene when combine with targeted mutation of Ldlr decreases susceptibility to atherosclerotic lesions.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029380 Ensembl Gene Model | MGI Sequence Detail 1875 C57BL/6J ±  kb
    transcript ENSMUST00000031327 Ensembl | MGI Sequence Detail 953 Not Applicable  
    polypeptide ENSMUSP00000031327 Ensembl | MGI Sequence Detail 96 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 33
      cDNA 22
      Primer pair 10
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-12226, MGD-MRK-37105, MGD-MRK-9878
    References
    more
    • Summaries
      All 196
      Developmental Gene Expression 37
      Gene Ontology 13
      Phenotypes 28
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:340032 Paredes A, et al., gamma-Linolenic acid in maternal milk drives cardiac metabolic maturation. Nature. 2023 Jun;618(7964):365-373

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory