Ptprv MGI Mouse Pseudogene Detail - MGI:108027 - protein tyrosine phosphatase receptor type V

Symbol

Ptprv
Name

protein tyrosine phosphatase receptor type V
Synonyms

Esp, mOST-PTP, OST, OST-PTP

Feature Type

polymorphic pseudogene

BioType Conflict
IDs

MGI:108027
NCBI Gene: 13924
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr1:135036236-135060313 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 58.24 cM, cytoband F-G
Mapping Data

3 experiments

SNPs within 2kb

249 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_108027	polymorphic pseudogene	Chr1:135036235-135060332 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0015112	unclassified non-coding RNA gene	Chr1:138844012-138869360 (-)
A/J	MGP_AJ_G0015085	unclassified non-coding RNA gene	Chr1:133598434-133625587 (-)
AKR/J	MGP_AKRJ_G0015048	unclassified non-coding RNA gene	Chr1:137579074-137602891 (-)
BALB/cJ	MGP_BALBcJ_G0015048	unclassified non-coding RNA gene	Chr1:133914434-133939299 (-)
C3H/HeJ	MGP_C3HHeJ_G0014871	unclassified non-coding RNA gene	Chr1:137672546-137696403 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0015505	unclassified non-coding RNA gene	Chr1:143868710-143895272 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0013251	unclassified non-coding RNA gene	Chr1:126712954-126736776 (-)
CAST/EiJ	MGP_CASTEiJ_G0014426	unclassified non-coding RNA gene	Chr1:136745272-136769916 (-)
CBA/J	MGP_CBAJ_G0014850	unclassified non-coding RNA gene	Chr1:148828564-148852378 (-)
DBA/2J	MGP_DBA2J_G0014943	unclassified non-coding RNA gene	Chr1:132602672-132626813 (-)
FVB/NJ	MGP_FVBNJ_G0014955	unclassified non-coding RNA gene	Chr1:131238371-131263662 (-)
LP/J	MGP_LPJ_G0015026	unclassified non-coding RNA gene	Chr1:140087242-140112867 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0014982	unclassified non-coding RNA gene	Chr1:154528720-154555500 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0015543	unclassified non-coding RNA gene	Chr1:137322255-137347647 (-)
PWK/PhJ	MGP_PWKPhJ_G0014218	unclassified non-coding RNA gene	Chr1:131624953-131650084 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0014007	unclassified non-coding RNA gene	Chr1:136285408-136311263 (-)
WSB/EiJ	MGP_WSBEiJ_G0014529	unclassified non-coding RNA gene	Chr1:137350858-137378475 (-)

Human Ortholog

PTPRVP, protein tyrosine phosphatase receptor type V, pseudogene

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PTPRVP, protein tyrosine phosphatase receptor type V, pseudogene
Synonyms

ESP, OST-PTP, PTPRV
Links

HGNC:13421

NCBI Gene ID: 148713
Chr Location

1q32.1; chr1:202168051-202189455 (+) GRCh38

MGI Vertebrate Homology

Ptprv stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: PTPRVP
Gene Tree

Ptprv

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Phenotype Summary

46 phenotypes from 4 alleles in 7 genetic backgrounds
6 phenotypes from multigenic genotypes
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

2
Endonuclease-mediated

1
Gene trapped

1
Radiation induced

1
Targeted

6
Transgenic

1
Genomic Mutations

3 involving Ptprv
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit increased resistance to diet-induced obesity, decreased circulating glucose levels, and decreased suseptibility to death induced by streptozotocin treatment.

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All GO Annotations

21
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

951
Tissues

93
cDNA Data

11
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

44
RefSeq

3
UniProt

4

Ensembl

ENSMUSG00000097993 (Evidence)
NCBI Gene

13924

			Length	Strain/Species	Flank
genomic	13924	NCBI Gene Model \| MGI Sequence Detail	24078	C57BL/6J	± kb
transcript	NR_153383	RefSeq \| MGI Sequence Detail	6089	C57BL/6
polypeptide	P70289	UniProt \| EBI \| MGI Sequence Detail	1705	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000013560 receptor-type tyrosine-protein phosphatase V

(term hierarchy)
EC

3.1.3.48
InterPro Domains

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR013783 Immunoglobulin-like fold

IPR016130 Protein-tyrosine phosphatase, active site

IPR003595 Protein-tyrosine phosphatase, catalytic

IPR029021 Protein-tyrosine phosphatase-like

IPR041201 PTPRJ, transmembrane domain

IPR000242 Tyrosine-specific protein phosphatase, PTPase domain

IPR000387 Tyrosine-specific protein phosphatases domain

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All nucleic 20

cDNA 12

Primer pair 3

Other 5

Microarray probesets 4

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MGD-MRK-37063, MGI:1927839

Summaries

All 46

Developmental Gene Expression 8

Gene Ontology 8

Phenotypes 19
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:236599 Dickinson ME, et al., High-throughput discovery of novel developmental phenotypes. Nature. 2016 Sep 14;537(7621):508-514

TSS for Ptprv:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr13825	Chr1:135060931-135060964 (-)	-635 bp
Tssr13824	Chr1:135060298-135060339 (-)	-6 bp
Tssr13823	Chr1:135060281-135060292 (-)	26 bp
Tssr13822	Chr1:135059485-135059493 (-)	824 bp
Tssr13821	Chr1:135058893-135058902 (-)	1,415 bp
Tssr13820	Chr1:135056940-135056953 (-)	3,366 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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