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Rgn
Gene Detail
Symbol

Name
ID
Rgn
regucalcin
MGI:108024
Synonyms
SMP30
Feature Type
protein coding gene
Genetic Map
Chromosome X
16.04 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
ChrX:20549787-20562089 bp, + strand
From VEGA annotation of GRCm38

  12303 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3437  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: senescence marker protein-30
Gene Tree: Rgn

Human
homologs
Human Homolog RGN, regucalcin
NCBI Gene ID 9104
neXtProt AC  NX_Q15493
Human Synonyms  GNL, HEL-S-41, RC, SMP30
Human Chr (Location)  Xp11.3; chrX:47078355-47093314 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from APF )
 
Mice homozygous for a disruption in this gene show increased levels of apoptosis.
 
Phenotype Images(1)
Interactions
Rgn interacts with 95 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (44 annotations)
Process cellular calcium ion homeostasis, L-ascorbic acid biosynthetic process, ...
Component cytoplasm, cytosol, ...
Function calcium ion binding, enzyme regulator activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (139)    Tissues (96)    Images (46)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 139
cDNA source data(65)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(67) Genomic(2) cDNA(65)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000017082 (Evidence)
Ensembl Gene ModelENSMUSG00000023070 (Evidence)
Entrez Gene19733 (Evidence)
UniGene2118
DFCITC1578726
DoTSDT.535886
NIA Mouse Gene IndexU019745
EC3.1.1.17
PDB4GNA, 4GN7, 4GN9, 4GN8
Consensus CDS ProjectCCDS30043.1
International Mouse Knockout Project StatusRgn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017082 VEGA Gene Model | MGI Sequence Detail 12303 C57BL/6J ±  kb
transcript OTTMUST00000041365 VEGA | MGI Sequence Detail 1607 Not Applicable 
polypeptide OTTMUSP00000018563 VEGA | MGI Sequence Detail 299 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(35 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008367 Regucalcin
InterPro IPR005511 Senescence marker protein-30 (SMP-30)
InterPro IPR011042 Six-bladed beta-propeller, TolB-like
InterPro IPR013658 SMP-30/Gluconolaconase/LRE-like region
Protein Ontology PR:000013941 regucalcin
References
(Earliest) J:29413 Fujita T, et al., Isolation of cDNA clone encoding human homologue of senescence marker protein-30 (SMP30) and its location on the X chromosome. Biochim Biophys Acta. 1995 Sep 19;1263(3):249-52
(Latest) J:212463 Takahashi K, et al., Ascorbic acid deficiency affects genes for oxidation-reduction and lipid metabolism in livers from SMP30/GNL knockout mice. Biochim Biophys Acta. 2014 Jul;1840(7):2289-98
All references(57)
Other
accession IDs
MGD-MRK-37060, MGI:2147859

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory