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Rgn Gene Detail
Summary
  • Symbol
    Rgn
  • Name
    regucalcin
  • Synonyms
    SMP30
  • Feature Type
    protein coding gene
  • IDs
    MGI:108024
    NCBI Gene: 19733
  • Gene Overview
    MyGene.info: RGN
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:20549787-20562089 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 16.04 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    35 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_108024
protein coding gene ChrX:20549766-20562089 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035591
protein coding gene ChrX:15444108-15456469 (+)
A/J MGP_AJ_G0035568
protein coding gene ChrX:15528967-15541215 (+)
AKR/J MGP_AKRJ_G0035501
protein coding gene ChrX:16046365-16058658 (+)
BALB/cJ MGP_BALBcJ_G0035561
protein coding gene ChrX:15283176-15295497 (+)
C3H/HeJ MGP_C3HHeJ_G0035279
protein coding gene ChrX:15648699-15661083 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036097
protein coding gene ChrX:15838979-15852134 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032961
protein coding gene ChrX:13768594-13780517 (+)
CAST/EiJ MGP_CASTEiJ_G0034570
protein coding gene ChrX:14957951-14970291 (+)
CBA/J MGP_CBAJ_G0035248
protein coding gene ChrX:16567952-16580646 (+)
DBA/2J MGP_DBA2J_G0035400
protein coding gene ChrX:15331766-15344108 (+)
FVB/NJ MGP_FVBNJ_G0035346
protein coding gene ChrX:15232573-15244767 (+)
LP/J MGP_LPJ_G0035482
protein coding gene ChrX:15684751-15697054 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035390
protein coding gene ChrX:16827044-16840315 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036104
protein coding gene ChrX:15356452-15368761 (+)
PWK/PhJ MGP_PWKPhJ_G0034271
protein coding gene ChrX:14521115-14533626 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034111
protein coding gene ChrX:15332758-15346232 (+)
WSB/EiJ MGP_WSBEiJ_G0034705
protein coding gene ChrX:15223884-15235855 (+)



Homology
more
  • Human Ortholog
    RGN, regucalcin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RGN, regucalcin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GNL, HEL-S-41, RC, SMP30
  • Links
    NCBI Gene ID: 9104
    neXtProt AC: NX_Q15493
    UniProt: Q15493

  • Chr Location
    Xp11.3; chrX:47078299-47093314 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 1 allele in 2 genetic backgrounds
    1 images
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption in this gene show increased levels of apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000023070 Ensembl Gene Model | MGI Sequence Detail 12303 C57BL/6J ±  kb
    transcript ENSMUST00000023832 Ensembl | MGI Sequence Detail 1607 Not Applicable  
    polypeptide ENSMUSP00000023832 Ensembl | MGI Sequence Detail 299 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 68
      Genomic 2
      cDNA 66

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-37060, MGI:2147859
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 5
      Gene Ontology 8
      Phenotypes 25
    • Earliest
      J:29413 Fujita T, et al., Isolation of cDNA clone encoding human homologue of senescence marker protein-30 (SMP30) and its location on the X chromosome. Biochim Biophys Acta. 1995 Sep 19;1263(3):249-52
    • Latest
      J:262823 Kasowitz SD, et al., Nuclear m6A reader YTHDC1 regulates alternative polyadenylation and splicing during mouse oocyte development. PLoS Genet. 2018 May;14(5):e1007412

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory