About   Help   FAQ
Rgn
Gene Detail
Symbol

Name
ID
Rgn
regucalcin
MGI:108024
Synonyms
SMP30
Feature Type
protein coding gene
Genetic Map
Chromosome X
16.04 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
ChrX:20549787-20562089 bp, + strand
From VEGA annotation of GRCm38

  12303 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3437  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RGN
Protein SuperFamily: senescence marker protein-30
Gene Tree: Rgn

Human
homologs
RGN, regucalcin
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 9104
neXtProt AC: NX_Q15493

Human Synonyms: GNL, HEL-S-41, RC, SMP30

Human Chr (Location): Xp11.3; chrX:47078355-47093314 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from APF )
 
Mice homozygous for a disruption in this gene show increased levels of apoptosis.
 
Phenotype Images(1)
Interactions
Rgn interacts with 94 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (44 annotations)
Process cellular calcium ion homeostasis, L-ascorbic acid biosynthetic process, ...
Component cytoplasm, cytosol, ...
Function calcium ion binding, enzyme regulator activity, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (139)    Tissues (96)    Images (46)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 139
cDNA source data(65)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rgn    NEW 
Molecular
reagents
All nucleic(67) Genomic(2) cDNA(65)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000017082 (Evidence)
Ensembl Gene Model ENSMUSG00000023070 (Evidence)
Entrez Gene 19733 (Evidence)
UniGene 2118
DFCI TC1578726
DoTS DT.535886
NIA Mouse Gene Index U019745
EC 3.1.1.17
PDB 4GN7, 4GN8, 4GN9, 4GNA
Consensus CDS Project CCDS30043.1
International Mouse Phenotyping Consortium Status Rgn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017082 VEGA Gene Model | MGI Sequence Detail 12303 C57BL/6J ±  kb
transcript OTTMUST00000041365 VEGA | MGI Sequence Detail 1607 Not Applicable 
polypeptide OTTMUSP00000018563 VEGA | MGI Sequence Detail 299 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(35 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008367 Regucalcin
InterPro IPR005511 Senescence marker protein-30 (SMP-30)
InterPro IPR011042 Six-bladed beta-propeller, TolB-like
InterPro IPR013658 SMP-30/Gluconolaconase/LRE-like region
Protein Ontology PR:000013941 regucalcin
References
(Earliest) J:34548 Fujita T, et al., Isolation and characterization of genomic and cDNA clones encoding mouse senescence marker protein-30 (SMP30). Biochim Biophys Acta. 1996 Jul 31;1308(1):49-57
(Latest) J:212463 Takahashi K, et al., Ascorbic acid deficiency affects genes for oxidation-reduction and lipid metabolism in livers from SMP30/GNL knockout mice. Biochim Biophys Acta. 2014 Jul;1840(7):2289-98
All references(56)
Other
accession IDs
MGD-MRK-37060, MGI:2147859

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/18/2015
MGI 6.0
The Jackson Laboratory