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Rhob Gene Detail
Summary
  • Symbol
    Rhob
  • Name
    ras homolog family member B
  • Synonyms
    Arhb
  • Feature Type
    protein coding gene
  • IDs
    MGI:107949
    NCBI Gene: 11852
  • Gene Overview
    MyGene.info: RHOB
Location & Maps
more
  • Sequence Map
    Chr12:8497763-8499985 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2223 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 12, 3.88 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    RHOB, ras homolog family member B
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RHOB, ras homolog family member B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARH6, ARHB, MST081, MSTP081, RHOH6
  • Links
    NCBI Gene ID: 388
    neXtProt AC: NX_P62745

  • Chr Location
    2p24; chr2:20447071-20449445 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    2
  • Targeted
    2
Homozygous mutation of this gene results in increased incidence of DMBA-induced skin tumors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000054364 Ensembl Gene Model | MGI Sequence Detail 2223 C57BL/6J ±  kb
transcript ENSMUST00000067384 Ensembl | MGI Sequence Detail 2223 Not Applicable  
polypeptide ENSMUSP00000067013 Ensembl | MGI Sequence Detail 196 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    14 from dbSNP Build 142
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000013977 rho-related GTP-binding protein RhoB
  • InterPro Domains
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR001806 Small GTPase superfamily
    IPR005225 Small GTP-binding protein domain
Molecular
Reagents
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  • All nucleic 178
    Genomic 4
    cDNA 174

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-36529, MGI:2144717
References
more
  • Summaries
    All 67
    Developmental Gene Expression 12
    Gene Ontology 11
    Phenotypes 17
  • Earliest
    J:113699 Adamson P, et al., Post-translational modifications of p21rho proteins. J Biol Chem. 1992 Oct 5;267(28):20033-8
  • Latest
    J:231326 Dubois F, et al., RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non-Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway. Cancer Res. 2016 Mar 15;76(6):1627-40

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory