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Rhob Gene Detail
Summary
  • Symbol
    Rhob
  • Name
    ras homolog family member B
  • Synonyms
    Arhb
  • Feature Type
    protein coding gene
  • IDs
    MGI:107949
    NCBI Gene: 11852
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:8547661-8550009 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 12, 3.88 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    16 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107949
protein coding gene Chr12:8547661-8550009 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019585
protein coding gene Chr12:5547758-5549980 (-)
A/J MGP_AJ_G0019552
protein coding gene Chr12:5388371-5390592 (-)
AKR/J MGP_AKRJ_G0019522
protein coding gene Chr12:5750916-5753138 (-)
BALB/cJ MGP_BALBcJ_G0019527
protein coding gene Chr12:5475007-5477228 (-)
C3H/HeJ MGP_C3HHeJ_G0019333
protein coding gene Chr12:5532066-5534288 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019976
protein coding gene Chr12:5697102-5699324 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017601
protein coding gene Chr12:5200502-5202735 (-)
CAST/EiJ MGP_CASTEiJ_G0018888
protein coding gene Chr12:5570615-5572835 (-)
CBA/J MGP_CBAJ_G0019304
protein coding gene Chr12:6247900-6250122 (-)
DBA/2J MGP_DBA2J_G0019417
protein coding gene Chr12:5348368-5350590 (-)
FVB/NJ MGP_FVBNJ_G0019408
protein coding gene Chr12:5313226-5315448 (-)
LP/J MGP_LPJ_G0019488
protein coding gene Chr12:5568840-5571062 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019441
protein coding gene Chr12:6034960-6037182 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020015
protein coding gene Chr12:5500335-5502556 (-)
PWK/PhJ MGP_PWKPhJ_G0018654
protein coding gene Chr12:5395739-5397961 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018445
protein coding gene Chr12:5511939-5514160 (-)
WSB/EiJ MGP_WSBEiJ_G0018939
protein coding gene Chr12:5539452-5541673 (-)



Homology
more
  • Human Ortholog
    RHOB, ras homolog family member B
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RHOB, ras homolog family member B
  • Synonyms
    ARH6, ARHB, MST081, MSTP081, RHOH6
  • Links
    NCBI Gene ID: 388
    neXtProt AC: NX_P62745
    UniProt: P62745

  • Chr Location
    2p24.1; chr2:20447074-20449440 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in increased incidence of DMBA-induced skin tumors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11852 NCBI Gene Model | MGI Sequence Detail 2349 C57BL/6J ±  kb
    transcript NM_007483 RefSeq | MGI Sequence Detail 2366 C57BL/6  
    polypeptide P62746 UniProt | EBI | MGI Sequence Detail 196 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 181
      Genomic 4
      cDNA 176
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-36529, MGI:2144717
    References
    more
    • Summaries
      All 87
      Developmental Gene Expression 15
      Gene Ontology 14
      Phenotypes 22
    • Earliest
      J:113699 Adamson P, et al., Post-translational modifications of p21rho proteins. J Biol Chem. 1992 Oct 5;267(28):20033-8
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory