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Rhob Gene Detail
Summary
  • Symbol
    Rhob
  • Name
    ras homolog family member B
  • Synonyms
    Arhb
  • Feature Type
    protein coding gene
  • IDs
    MGI:107949
    NCBI Gene: 11852
  • Gene Overview
    MyGene.info: RHOB
  • Alliance
Location & Maps
more
  • Genetic Map
    Chromosome 12, 3.88 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    RHOB, ras homolog family member B
  • Vertebrate Orthologs
    9
  • Human Ortholog
    RHOB, ras homolog family member B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARH6, ARHB, MST081, MSTP081, RHOH6
  • Links
    NCBI Gene ID: 388
    neXtProt AC: NX_P62745
    UniProt: P62745

  • Chr Location
    2p24.1; chr2:20447071-20449445 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in increased incidence of DMBA-induced skin tumors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11852 NCBI Gene Model | MGI Sequence Detail 2228 C57BL/6J ±  kb
    transcript NM_007483 RefSeq | MGI Sequence Detail 2366 C57BL/6  
    polypeptide P62746 UniProt | EBI | MGI Sequence Detail 196 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      14 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 179
      Genomic 4
      cDNA 174
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
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    MGD-MRK-36529, MGI:2144717
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 14
      Gene Ontology 12
      Phenotypes 18
    • Earliest
      J:113699 Adamson P, et al., Post-translational modifications of p21rho proteins. J Biol Chem. 1992 Oct 5;267(28):20033-8
    • Latest
      J:250125 Escamilla CO, et al., Kctd13 deletion reduces synaptic transmission via increased RhoA. Nature. 2017 Nov 9;551(7679):227-231

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory