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Prmt1 Gene Detail
Summary
  • Symbol
    Prmt1
  • Name
    protein arginine N-methyltransferase 1
  • Synonyms
    6720434D09Rik, Hrmt1l2
  • Feature Type
    protein coding gene
  • IDs
    MGI:107846
    NCBI Gene: 15469
  • Gene Overview
    MyGene.info: PRMT1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:44976755-44986420 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 29.07 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    91 from dbSNP Build 142
  • Strain Annotations
    1
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107846
protein coding gene Chr7:44975989-44986568 (-)
129S1/SvImJ no annotation
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    PRMT1, protein arginine methyltransferase 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PRMT1, protein arginine methyltransferase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ANM1, HCP1, HRMT1L2, IR1B4
  • Links
    NCBI Gene ID: 3276
    neXtProt AC: NX_Q99873
    UniProt: Q99873

  • Chr Location
    19q13.33; chr19:49676166-49688450 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Embryos homozygous for a null mutation die before E6.5 and exhibit abnormal embryonic tissue morphology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15469 NCBI Gene Model | MGI Sequence Detail 9666 C57BL/6J ±  kb
    transcript NR_045521 RefSeq | MGI Sequence Detail 1524 C57BL/6  
    polypeptide Q9JIF0 UniProt | EBI | MGI Sequence Detail 371 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      16 Sequences
    • EC
    • InterPro Domains
      IPR025799 Protein arginine N-methyltransferase
      IPR029063 S-adenosyl-L-methionine-dependent methyltransferase
    Molecular
    Reagents
    less
    • All nucleic 215
      Genomic 1
      cDNA 210
      Primer pair 3
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-36423, MGI:1924993, MGI:2142221
    References
    more
    • Summaries
      All 81
      Developmental Gene Expression 11
      Gene Ontology 17
      Phenotypes 24
    • Earliest
      J:33751 Lin WJ, et al., The mammalian immediate-early TIS21 protein and the leukemia-associated BTG1 protein interact with a protein-arginine N-methyltransferase. J Biol Chem. 1996 Jun 21;271(25):15034-44
    • Latest
      J:264205 Gou Y, et al., Prmt1 regulates craniofacial bone formation upstream of Msx1. Mech Dev. 2018 May 1;

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory