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Prmt1
Gene Detail
Symbol

Name
ID
Prmt1
protein arginine N-methyltransferase 1
MGI:107846
Synonyms
6720434D09Rik, Hrmt1l2
Feature Type
protein coding gene
Genetic Map
Chromosome 7
29.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:44975989-44986492 bp, - strand
From VEGA annotation of GRCm38

  10504 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21477  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PRMT1
Protein SuperFamily: type 1 arginine N-methyltransferase
Gene Tree: Prmt1

Human
homologs
PRMT1, protein arginine methyltransferase 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3276
neXtProt AC: NX_Q99873

Human Synonyms: ANM1, HCP1, HRMT1L2, IR1B4

Human Chr (Location): 19q13.3; chr19:49677152-49688450 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(26) : Gene trapped(22) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Embryos homozygous for a null mutation die before E6.5 and exhibit abnormal embryonic tissue morphology.
 
Interactions
Prmt1 interacts with 213 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (119 annotations)
Process histone H4-R3 methylation, histone methylation, ...
Component cytoplasm, cytosol, ...
Function 1-hydroxy-6-methoxypyrene methyltransferase activity, 1-hydroxypyrene methyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (195)    Tissues (76)    Images (28)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 141
In situ reporter (knock in) 26
Northern blot 13
RT-PCR 15
cDNA source data(209)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase prmt1 ; ZFIN prmt1    NEW 
Molecular
reagents
All nucleic(214) Genomic(1) cDNA(209) Primer pair(3) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000020537 (Evidence)
Ensembl Gene Model ENSMUSG00000052429 (Evidence)
Entrez Gene 15469 (Evidence)
UniGene 27545
DFCI TC1572111, TC1596095, TC1666786, TC1672822, TC1775282
DoTS DT.99863686, DT.91293160, DT.101151706, DT.101151704, DT.101151668
NIA Mouse Gene Index U028507
EC 2.1.1.-, 2.1.1.125
Consensus CDS Project CCDS21222.1, CCDS57547.1
International Mouse Phenotyping Consortium Status Prmt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020537 VEGA Gene Model | MGI Sequence Detail 10504 C57BL/6J ±  kb
transcript OTTMUST00000048689 VEGA | MGI Sequence Detail 1360 Not Applicable 
polypeptide OTTMUSP00000022387 VEGA | MGI Sequence Detail 371 Not Applicable 

For the selected sequences
All sequences(90) RefSeq(11) UniProt(11)
Polymorphisms
RFLP(1) : SNPs within 2kb(99 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR025714 Methyltransferase domain
InterPro IPR025799 Protein arginine N-methyltransferase
Protein Ontology PR:000013252 protein arginine N-methyltransferase 1
References
(Earliest) J:33751 Lin WJ, et al., The mammalian immediate-early TIS21 protein and the leukemia-associated BTG1 protein interact with a protein-arginine N-methyltransferase. J Biol Chem. 1996 Jun 21;271(25):15034-44
(Latest) J:220566 Park MJ, et al., Thioredoxin-interacting protein mediates hepatic lipogenesis and inflammation via PRMT1 and PGC-1alpha regulation in vitro and in vivo. J Hepatol. 2014 Nov;61(5):1151-7
All references(67)
Other
accession IDs
MGD-MRK-36423, MGI:1924993, MGI:2142221

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory