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Prmt1
Gene Detail
 Symbol
Name
ID
Prmt1
protein arginine N-methyltransferase 1
MGI:107846
Synonyms 6720434D09Rik, Hrmt1l2
Feature Type protein coding gene
Genetic Map
Chromosome 7
29.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr7:44975989-44986492 bp, - strand
From VEGA annotation of GRCm38

  10504 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21477  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: type 1 arginine N-methyltransferase
Gene Tree: Prmt1

Human
homologs
Human Homolog PRMT1, protein arginine methyltransferase 1
NCBI Gene ID 3276
neXtProt AC  NX_Q99873
Human Synonyms  ANM1, HCP1, HRMT1L2, IR1B4
Human Chr (Location)  19q13.3; chr19:49677152-49688450 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(25) : Gene trapped(22) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Embryos homozygous for a null mutation die before E6.5 and exhibit abnormal embryonic tissue morphology.
 
Interactions
Prmt1 interacts with 214 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (111 annotations)
Process histone H4-R3 methylation, histone methylation, ...
Component cytoplasm, cytosol, ...
Function 1-hydroxy-6-methoxypyrene methyltransferase activity, 1-hydroxypyrene methyltransferase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (195)    Tissues (76)    Images (28)
Theiler Stages: 4, 9, 11, 13, 15, 19, 21, 23, 27, 28
Assay TypeResults
RNA in situ 141
In situ reporter (knock in) 26
Northern blot 13
RT-PCR 15
cDNA source data(209)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(214) Genomic(1) cDNA(209) Primer pair(3) Other(1)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000020537 (Evidence)
Ensembl Gene ModelENSMUSG00000052429 (Evidence)
Entrez Gene15469 (Evidence)
UniGene27545
DFCITC1572111, TC1596095, TC1666786, TC1672822, TC1775282
DoTSDT.101151668, DT.101151704, DT.101151706, DT.91293160, DT.99863686
NIA Mouse Gene IndexU028507
EC2.1.1.-, 2.1.1.125
Consensus CDS ProjectCCDS21222.1, CCDS57547.1
International Mouse Knockout Project StatusPrmt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020537 VEGA Gene Model | MGI Sequence Detail 10504 C57BL/6J ±  kb
transcript OTTMUST00000048689 VEGA | MGI Sequence Detail 1360 Not Applicable 
polypeptide OTTMUSP00000022387 VEGA | MGI Sequence Detail 371 Not Applicable 

For the selected sequences
All sequences(87) RefSeq(9) UniProt(11)
Polymorphisms RFLP(1) : SNPs within 2kb(99 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR025714 Methyltransferase domain
InterPro IPR025799 Protein arginine N-methyltransferase
Protein Ontology PR:000013252 protein arginine N-methyltransferase 1
References (Earliest) J:33751 Lin WJ, et al., The mammalian immediate-early TIS21 protein and the leukemia-associated BTG1 protein interact with a protein-arginine N-methyltransferase. J Biol Chem. 1996 Jun 21;271(25):15034-44
(Latest) J:203762 Burton A, et al., Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo. Cell Rep. 2013 Nov 14;5(3):687-701
All references(65)
Other
accession IDs
MGD-MRK-36423, MGI:1924993, MGI:2142221

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory