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Neurod2 Gene Detail
Summary
  • Symbol
    Neurod2
  • Name
    neurogenic differentiation 2
  • Synonyms
    bHLHa1, Ndrf
  • Feature Type
    protein coding gene
  • IDs
    MGI:107755
    NCBI Gene: 18013
  • Gene Overview
    MyGene.info: NEUROD2
Location & Maps
more
  • Sequence Map
    Chr11:98325415-98329648 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4234 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    NEUROD2, neuronal differentiation 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    NEUROD2, neuronal differentiation 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    bHLHa1, NDRF
  • Links
    NCBI Gene ID: 4761
    neXtProt AC: NX_Q15784

  • Chr Location
    17q12; chr17:39603768-39607922 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 1 genetic background
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Targeted
    5
  • Genomic Mutations
    1 involving Neurod2
  • Incidental Mutations
Homozygotes for a targeted null mutation show elevated neuronal apoptosis resulting in ataxia, incoordination, elevated seizure susceptibility, and death by 35 days. Heterozygotes are moderately affected, and adults are subject to unexplained death.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002638 VEGA Gene Model | MGI Sequence Detail 4234 C57BL/6J ±  kb
transcript OTTMUST00000005157 VEGA | MGI Sequence Detail 3142 Not Applicable  
polypeptide OTTMUSP00000002450 VEGA | MGI Sequence Detail 383 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    8 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000011153 neurogenic differentiation factor 2
  • InterPro Domains
    IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
    IPR032649 Neurogenic differentiation factor 2
    IPR022575 Neurogenic differentiation factor, domain of unknown function
    IPR016637 Neurogenic differentiation factor NeuroD
Molecular
Reagents
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  • All nucleic 26
    Genomic 1
    cDNA 24
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-33898, MGD-MRK-36331
References
more
  • Summaries
    All 60
    Developmental Gene Expression 18
    Gene Ontology 11
    Phenotypes 18
  • Earliest
    J:32452 Yasunami M, et al., Molecular cloning and characterization of a cDNA encoding a novel basic helix-loop-helix protein structurally related to Neuro-D/BHF1. Biochem Biophys Res Commun. 1996 Mar 27;220(3):754-8
  • Latest
    J:210222 Hupe M, et al., Evaluation of TRAP-sequencing technology with a versatile conditional mouse model. Nucleic Acids Res. 2014 Jan;42(2):e14

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory