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Neurod2
Gene Detail
 Symbol
Name
ID
Neurod2
neurogenic differentiation 2
MGI:107755
Synonyms bHLHa1, Ndrf
Feature Type protein coding gene
Genetic Map
Chromosome 11
61.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr11:98325415-98329648 bp, - strand
From VEGA annotation of GRCm38

  4234 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4489  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: basic helix-loop-helix transcription factor NeuroD
Gene Tree: Neurod2

Human
homologs
Human Homolog NEUROD2, neuronal differentiation 2
NCBI Gene ID 4761
neXtProt AC  NX_Q15784
Human Synonyms  bHLHa1, NDRF
Human Chr (Location)  17q12; chr17:39603768-39607922 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation show elevated neuronal apoptosis resulting in ataxia, incoordination, elevated seizure susceptibility, and death by 35 days. Heterozygotes are moderately affected, and adults are subject to unexplained death.
 
Interactions
Neurod2 interacts with 258 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process associative learning, behavioral fear response, ...
Component nucleus
Function DNA binding, E-box binding, ...
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (182)    Tissues (93)    Images (31)
Theiler Stages: 5, 12, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 145
Northern blot 36
RT-PCR 1
cDNA source data(24)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) Genomic(1) cDNA(24) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000002638 (Evidence)
Ensembl Gene ModelENSMUSG00000038255 (Evidence)
Entrez Gene18013 (Evidence)
UniGene4814
DFCITC1585283, TC1591159, TC1619601
DoTSDT.40167514, DT.94165419, DT.97373471
NIA Mouse Gene IndexU033362
Consensus CDS ProjectCCDS25343.1
International Mouse Knockout Project StatusNeurod2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002638 VEGA Gene Model | MGI Sequence Detail 4234 C57BL/6J ±  kb
transcript OTTMUST00000005157 VEGA | MGI Sequence Detail 3142 Not Applicable 
polypeptide OTTMUSP00000002450 VEGA | MGI Sequence Detail 383 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(2)
Polymorphisms RFLP(2) : SNPs within 2kb(8 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR022575 Neurogenic differentiation factor, domain of unknown function
InterPro IPR016637 Transcription factor, basic helix-loop-helix, NeuroD
Protein Ontology PR:000011153 neurogenic differentiation factor 2
References (Earliest) J:32452 Yasunami M, et al., Molecular cloning and characterization of a cDNA encoding a novel basic helix-loop-helix protein structurally related to Neuro-D/BHF1. Biochem Biophys Res Commun. 1996 Mar 27;220(3):754-8
(Latest) J:193910 Bormuth I, et al., Neuronal basic helix-loop-helix proteins Neurod2/6 regulate cortical commissure formation before midline interactions. J Neurosci. 2013 Jan 9;33(2):641-51
All references(63)
Other
accession IDs
MGD-MRK-33898, MGD-MRK-36331

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory