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Neurod2
Gene Detail
Symbol

Name
ID
Neurod2
neurogenic differentiation 2
MGI:107755
Synonyms
bHLHa1, Ndrf
Feature Type
protein coding gene
Genetic Map
Chromosome 11
61.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr11:98325415-98329648 bp, - strand
From VEGA annotation of GRCm38

  4234 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4489  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: NEUROD2
Protein SuperFamily: basic helix-loop-helix transcription factor NeuroD
Gene Tree: Neurod2

Human
homologs
NEUROD2, neuronal differentiation 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 4761
neXtProt AC: NX_Q15784

Human Synonyms: bHLHa1, NDRF

Human Chr (Location): 17q12; chr17:39603768-39607922 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Genomic Mutations involving Neurod2 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation show elevated neuronal apoptosis resulting in ataxia, incoordination, elevated seizure susceptibility, and death by 35 days. Heterozygotes are moderately affected, and adults are subject to unexplained death.
 
Interactions
Neurod2 interacts with 258 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process associative learning, behavioral fear response, ...
Component nucleus
Function DNA binding, E-box binding, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (182)    Tissues (98)    Images (31)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 145
Northern blot 36
RT-PCR 1
cDNA source data(24)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase neurod2 ; ZFIN neurod2    NEW 
Molecular
reagents
All nucleic(26) Genomic(1) cDNA(24) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000002638 (Evidence)
Ensembl Gene Model ENSMUSG00000038255 (Evidence)
Entrez Gene 18013 (Evidence)
UniGene 4814
DFCI TC1585283, TC1619601, TC1591159
DoTS DT.97373471, DT.94165419, DT.40167514
NIA Mouse Gene Index U033362
Consensus CDS Project CCDS25343.1
International Mouse Phenotyping Consortium Status Neurod2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002638 VEGA Gene Model | MGI Sequence Detail 4234 C57BL/6J ±  kb
transcript OTTMUST00000005157 VEGA | MGI Sequence Detail 3142 Not Applicable 
polypeptide OTTMUSP00000002450 VEGA | MGI Sequence Detail 383 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(2) : SNPs within 2kb(8 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
InterPro IPR022575 Neurogenic differentiation factor, domain of unknown function
InterPro IPR016637 Transcription factor, basic helix-loop-helix, NeuroD
Protein Ontology PR:000011153 neurogenic differentiation factor 2
References
(Earliest) J:32452 Yasunami M, et al., Molecular cloning and characterization of a cDNA encoding a novel basic helix-loop-helix protein structurally related to Neuro-D/BHF1. Biochem Biophys Res Commun. 1996 Mar 27;220(3):754-8
(Latest) J:210222 Hupe M, et al., Evaluation of TRAP-sequencing technology with a versatile conditional mouse model. Nucleic Acids Res. 2014 Jan;42(2):e14
All references(63)
Other
accession IDs
MGD-MRK-33898, MGD-MRK-36331

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory