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Kif3a
Gene Detail
 Symbol
Name
ID
Kif3a
kinesin family member 3A
MGI:107689
Synonyms Kif3, Kifl, kinesin-II subunit, Kns3, N-4 kinesin
Feature Type protein coding gene
Genetic Map
Chromosome 11
31.97 cM, cytoband A5-B1
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr11:53567379-53601967 bp, + strand
From VEGA annotation of GRCm38

  34589 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:38266  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: kinesin-like protein KIF3
Gene Tree: Kif3a

Human
homologs
Human Homolog KIF3A, kinesin family member 3A
NCBI Gene ID 11127
neXtProt AC  NX_Q9Y496
Human Synonyms  FLA10, KLP-20
Human Chr (Location)  5q31; chr5:132689653-132737573 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Chemically induced (ENU)(1) Gene trapped(3) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Nullizygous mutations result in embryonic lethality, failure to synthesize cilia in the embryonic node, randomization of left-right asymmetry and structural abnormalities of the neural tube, pericardium, branchial arches, and somites.
 
Human Diseases Modeled Using Mouse Kif3a (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(9)
Interactions
Kif3a interacts with 221 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (55 annotations)
Process anterior/posterior pattern specification, ATP catabolic process, ...
Component axoneme, cell projection, ...
Function ATPase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (8)    Tissues (2)    Images (3)
Theiler Stages: 15, 28
Assay TypeResults
Northern blot 2
Western blot 6
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(25) Genomic(5) cDNA(18) Other(2)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000005634 (Evidence)
Ensembl Gene ModelENSMUSG00000018395 (Evidence)
Entrez Gene16568 (Evidence)
DFCITC1575589, TC1608647, TC1643336
NIA Mouse Gene IndexU054878
Consensus CDS ProjectCCDS48795.1, CCDS70185.1
International Mouse Knockout Project StatusKif3a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005634 VEGA Gene Model | MGI Sequence Detail 34589 C57BL/6J ±  kb
transcript OTTMUST00000071552 VEGA | MGI Sequence Detail 2178 Not Applicable 
polypeptide OTTMUSP00000036689 VEGA | MGI Sequence Detail 725 Not Applicable 

For the selected sequences
All sequences(88) RefSeq(12) UniProt(13)
Polymorphisms RFLP(1) : SNPs within 2kb(408 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001752 Kinesin, motor domain
InterPro IPR019821 Kinesin, motor region, conserved site
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000009311 kinesin-like protein KIF3A
References (Earliest) J:3448 Aizawa H, et al., Kinesin family in murine central nervous system. J Cell Biol. 1992 Dec;119(5):1287-96
(Latest) J:211665 Chaya T, et al., ICK is essential for cell type-specific ciliogenesis and the regulation of ciliary transport. EMBO J. 2014 Jun 2;33(11):1227-42
All references(122)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-11592, MGD-MRK-36264, MGI:2136248, MGI:2136249, MGI:2144502, MGI:894290

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory