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Ifnar1
Gene Detail
Symbol

Name
ID
Ifnar1
interferon (alpha and beta) receptor 1
MGI:107658
Synonyms
Ifar, IFN-alpha/betaR, Ifrc
Feature Type
protein coding gene
Genetic Map
Chromosome 16
52.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr16:91485238-91507441 bp, + strand
From VEGA annotation of GRCm38

  22204 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:524  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 2 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: IFNAR1
Protein SuperFamily: interferon-alpha/beta receptor 1
Gene Tree: Ifnar1

Human
homologs
IFNAR1, interferon (alpha, beta and omega) receptor 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3454
neXtProt AC: NX_P17181

Human Synonyms: AVP, IFN-alpha-REC, IFNAR, IFNBR, IFRC

Human Chr (Location): 21q22.11; chr21:33324443-33359823 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Chemically induced (ENU)(2) Gene trapped(4) Targeted(11)
Genomic Mutations involving Ifnar1 (5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted null mutations exhibit increased susceptibility to viral infection, elevated levels of myeloid lineage cells in the peripheral blood and bone marrow, and reduced immune response to immunostimulatory DNA.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Ifnar1 interacts with 215 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (7 records)
Data Summary: Results (364)    Tissues (201)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 303
Northern blot 45
RT-PCR 16
cDNA source data(100)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100498552    NEW 
Molecular
reagents
All nucleic(104) Genomic(2) cDNA(100) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000027185 (Evidence)
Ensembl Gene Model ENSMUSG00000022967 (Evidence)
Entrez Gene 15975 (Evidence)
UniGene 502
DFCI TC1653081, TC1609923, TC1595569, TC1576138
DoTS DT.101364858, DT.101734556, DT.87049432, DT.60118043
NIA Mouse Gene Index U017374
EC 6.3.4.13
PDB 3WCY
Consensus CDS Project CCDS28326.1
International Mouse Phenotyping Consortium Status Ifnar1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027185 VEGA Gene Model | MGI Sequence Detail 22204 C57BL/6J ±  kb
transcript OTTMUST00000067225 VEGA | MGI Sequence Detail 3909 Not Applicable 
polypeptide OTTMUSP00000033796 VEGA | MGI Sequence Detail 590 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(3) UniProt(5)
Polymorphisms
RFLP(2) : SNPs within 2kb(60 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR016669 Interferon alpha/beta receptor 1
InterPro IPR015373 Interferon alpha/beta receptor, beta chain
Protein Ontology PR:000008922 interferon-alpha/beta receptor alpha chain
References
(Earliest) J:6319 Cox DR, et al., Genes coding for sensitivity to interferon (IfRec) and soluble superoxide dismutase (SOD-1) are linked in mouse and man and map to mouse chromosome 16. Proc Natl Acad Sci U S A. 1980 Apr;77(4):2168-72
(Latest) J:221392 Barkhouse DA, et al., Expression of interferon gamma by a recombinant rabies virus strongly attenuates the pathogenicity of the virus via induction of type I interferon. J Virol. 2015 Jan;89(1):312-22
All references(630)
Other
accession IDs
MGD-MRK-11211, MGD-MRK-11223, MGD-MRK-36233

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory