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Ifnar1 Gene Detail
Summary
  • Symbol
    Ifnar1
  • Name
    interferon (alpha and beta) receptor 1
  • Synonyms
    Ifar, IFN-alpha/betaR, Ifrc
  • Feature Type
    protein coding gene
  • IDs
    MGI:107658
    NCBI Gene: 15975
  • Gene Overview
    MyGene.info: IFNAR1
Location & Maps
more
  • Sequence Map
    Chr16:91485238-91507441 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22204 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    IFNAR1, interferon alpha and beta receptor subunit 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    IFNAR1, interferon alpha and beta receptor subunit 1
    Orthology source: HomoloGene
  • Synonyms
    AVP, IFN-alpha-REC, IFNAR, IFNBR, IFRC
  • Links
    NCBI Gene ID: 3454
    neXtProt AC: NX_P17181

  • Chr Location
    21q22.11; chr21:33324443-33359823 (+)  GRCh38.p2

Human Diseases
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  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    33 phenotypes from 5 alleles in 10 genetic backgrounds
    40 phenotypes from multigenic genotypes
    563 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    20
  • Chemically induced (ENU)
    2
  • Gene trapped
    4
  • Targeted
    14
  • Genomic Mutations
    6 involving Ifnar1
  • Incidental Mutations
Homozygotes for targeted null mutations exhibit increased susceptibility to viral infection, elevated levels of myeloid lineage cells in the peripheral blood and bone marrow, and reduced immune response to immunostimulatory DNA.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027185 VEGA Gene Model | MGI Sequence Detail 22204 C57BL/6J ±  kb
transcript OTTMUST00000067228 VEGA | MGI Sequence Detail 2771 Not Applicable  
polypeptide OTTMUSP00000033798 VEGA | MGI Sequence Detail 590 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    61 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 104
    Genomic 2
    cDNA 100
    Primer pair 1
    Other 1

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-11211, MGD-MRK-11223, MGD-MRK-36233
References
more
  • Summaries
    All 672
    Developmental Gene Expression 7
    Diseases 1
    Gene Ontology 13
    Phenotypes 563
  • Earliest
    J:6319 Cox DR, et al., Genes coding for sensitivity to interferon (IfRec) and soluble superoxide dismutase (SOD-1) are linked in mouse and man and map to mouse chromosome 16. Proc Natl Acad Sci U S A. 1980 Apr;77(4):2168-72
  • Latest
    J:230644 Mostafavi S, et al., Parsing the Interferon Transcriptional Network and Its Disease Associations. Cell. 2016 Jan 28;164(3):564-78

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory