Ifnar1
Gene Detail

Symbol Name ID

Ifnar1 interferon (alpha and beta) receptor 1 MGI:107658

Synonyms

Ifar, IFN-alpha/betaR, Ifrc

Feature Type

protein coding gene

Genetic Map

Chromosome 16

52.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(14)

Sequence Map

Chr16:91485238-91507441 bp, + strand From VEGA annotation of GRCm38   22204 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:524  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 2 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: interferon-alpha/beta receptor 1
Gene Tree: Ifnar1

Human homologs

Human Homolog		IFNAR1, interferon (alpha, beta and omega) receptor 1
NCBI Gene ID		3454
neXtProt AC		NX_P17181
Human Synonyms		AVP, IFN-alpha-REC, IFNAR, IFNBR, IFRC
Human Chr (Location)		21q22.11; chr21:34697214-34732129 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(10) : Targeted(5) Gene trapped(4) Chemically induced(1)
 

Homozygotes for targeted null mutations exhibit increased susceptibility to viral infection, elevated levels of myeloid lineage cells in the peripheral blood and bone marrow, and reduced immune response to immunostimulatory DNA.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	cytokine-mediated signaling pathway, defense response to virus, ...
Component	integral to membrane, membrane
Function	interferon receptor activity, phosphoribosylamine-glycine ligase activity

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (364)    Tissues (194)    Images (25)
Theiler Stages: 12, 13, 15, 16, 17, 19, 20, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	303
Northern blot	45
RT-PCR	16

cDNA source data(106)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(110) Genomic(2) cDNA(106) Primer pair(1) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000027185 (Evidence)
Ensembl Gene Model	ENSMUSG00000022967 (Evidence)
Entrez Gene	15975 (Evidence)
UniGene	502
DFCI	TC1576138, TC1595569, TC1609923, TC1653081
DoTS	DT.101364858, DT.101734556, DT.60118043, DT.87049432
NIA Mouse Gene Index	U017374
EC	6.3.4.13
Consensus CDS Project	CCDS28326.1
International Mouse Knockout Project Status	Ifnar1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000027185	VEGA Gene Model | MGI Sequence Detail	22204	C57BL/6J
transcript	OTTMUST00000067227	VEGA | MGI Sequence Detail	3372	Not Applicable
polypeptide	OTTMUSP00000033797	VEGA | MGI Sequence Detail	590	Not Applicable

All sequences(63) RefSeq(2) UniProt(5)

Polymorphisms

RFLP(2) : SNPs(51 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR016669	Interferon alpha/beta receptor 1
InterPro	IPR015373	Interferon alpha/beta receptor, beta chain
Protein Ontology	PR:000008922	interferon-alpha/beta receptor alpha chain

References

(Earliest) J:6319 Cox DR, et al., Genes coding for sensitivity to interferon (IfRec) and soluble superoxide dismutase (SOD-1) are linked in mouse and man and map to mouse chromosome 16. Proc Natl Acad Sci U S A. 1980 Apr;77(4):2168-72
(Latest) J:196419 Yang CW, et al., Neutrophils control the magnitude and spread of the immune response in a thromboxane A2-mediated process. J Exp Med. 2013 Feb 11;210(2):375-87
All references(529)

Other accession IDs

MGD-MRK-11211, MGD-MRK-11223, MGD-MRK-36233