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Ifnar1
Gene Detail
Symbol

Name
ID
Ifnar1
interferon (alpha and beta) receptor 1
MGI:107658
Synonyms
Ifar, IFN-alpha/betaR, Ifrc
Feature Type
protein coding gene
Genetic Map
Chromosome 16
52.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr16:91485238-91507441 bp, + strand
From VEGA annotation of GRCm38

  22204 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:524  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 2 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: interferon-alpha/beta receptor 1
Gene Tree: Ifnar1

Human
homologs
Human Homolog IFNAR1, interferon (alpha, beta and omega) receptor 1
NCBI Gene ID 3454
neXtProt AC  NX_P17181
Human Synonyms  AVP, IFN-alpha-REC, IFNAR, IFNBR, IFRC
Human Chr (Location)  21q22.11; chr21:33324443-33359823 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Chemically induced (ENU)(2) Gene trapped(4) Targeted(9)
Genomic Mutations involving Ifnar1 (3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit increased susceptibility to viral infection, elevated levels of myeloid lineage cells in the peripheral blood and bone marrow, and reduced immune response to immunostimulatory DNA.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Ifnar1 interacts with 215 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (7 records)
Data Summary: Results (364)    Tissues (201)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 303
Northern blot 45
RT-PCR 16
cDNA source data(100)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(104) Genomic(2) cDNA(100) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000027185 (Evidence)
Ensembl Gene ModelENSMUSG00000022967 (Evidence)
Entrez Gene15975 (Evidence)
UniGene502
DFCITC1576138, TC1595569, TC1609923, TC1653081
DoTSDT.101364858, DT.101734556, DT.60118043, DT.87049432
NIA Mouse Gene IndexU017374
EC6.3.4.13
PDB3WCY
Consensus CDS ProjectCCDS28326.1
International Mouse Knockout Project StatusIfnar1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027185 VEGA Gene Model | MGI Sequence Detail 22204 C57BL/6J ±  kb
transcript OTTMUST00000067225 VEGA | MGI Sequence Detail 3909 Not Applicable 
polypeptide OTTMUSP00000033796 VEGA | MGI Sequence Detail 590 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(3) UniProt(5)
Polymorphisms
RFLP(2) : SNPs within 2kb(60 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR016669 Interferon alpha/beta receptor 1
InterPro IPR015373 Interferon alpha/beta receptor, beta chain
Protein Ontology PR:000008922 interferon-alpha/beta receptor alpha chain
References
(Earliest) J:6319 Cox DR, et al., Genes coding for sensitivity to interferon (IfRec) and soluble superoxide dismutase (SOD-1) are linked in mouse and man and map to mouse chromosome 16. Proc Natl Acad Sci U S A. 1980 Apr;77(4):2168-72
(Latest) J:213428 Bald T, et al., Immune cell-poor melanomas benefit from PD-1 blockade after targeted type I IFN activation. Cancer Discov. 2014 Jun;4(6):674-87
All references(604)
Other
accession IDs
MGD-MRK-11211, MGD-MRK-11223, MGD-MRK-36233

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory