Kifap3 MGI Mouse Gene Detail - MGI:107566 - kinesin-associated protein 3

Kifap3 Gene Detail

Symbol

Kifap3
Name

kinesin-associated protein 3
Synonyms

KAP3, Smg GDS

Feature Type

protein coding gene
IDs

MGI:107566
NCBI Gene: 16579
Gene Overview

MyGene.info: KIFAP3
Alliance

gene page

Sequence Map

Chr1:163779583-163917109 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

137527 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 71.08 cM, cytoband H1
Mapping Data

2 experiments

Human Ortholog

KIFAP3, kinesin associated protein 3

Vertebrate Orthologs

9

Human Ortholog

KIFAP3, kinesin associated protein 3
Orthology source: HomoloGene, HGNC
Synonyms

dJ190I16.1, FLA3, KAP-1, KAP3, KAP-3, SMAP, Smg-GDS
Links

HGNC:17060

NCBI Gene ID: 22920

neXtProt AC: NX_Q92845

UniProt: Q92845
Chr Location

1q24.2; chr1:169921329-170074741 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 7799
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
HCOP

human homology predictions: KIFAP3
Gene Tree

Kifap3

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Phenotype Summary

34 phenotypes from 4 alleles in 3 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

2
Gene trapped

4
Targeted

5
Genomic Mutations

2 involving Kifap3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

36 strains or lines available

About 70% of homozygotes for a knock-out mutation die of heart failure shortly after birth due to massive cardiomyocyte apoptosis triggered by cardiovascular overload. Neonatal thymocytes and developing neuronal cells undergo apoptosis while cultured thymocytes are susceptible to apoptotic inducers.

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All GO Annotations

25
GO References

7

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

101
Tissues

12
cDNA Data

131
Literature Summary

3

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Kifap3 interacts with 259 markers (Mir1b, Mir7-1, Mir7-2, ...) View All

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All Sequences

37
RefSeq

8
UniProt

3
CCDS

CCDS35751.1, CCDS78729.1
UniGene

4651

			Length	Strain/Species	Flank
genomic	OTTMUSG00000018234	VEGA Gene Model \| MGI Sequence Detail	137527	C57BL/6J	± kb
transcript	OTTMUST00000044068	VEGA \| MGI Sequence Detail	3946	Not Applicable
polypeptide	OTTMUSP00000019807	VEGA \| MGI Sequence Detail	793	Not Applicable

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SNPs within 2kb

1101 from dbSNP Build 142

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UniProt

3 Sequences
Protein Ontology

PR:000009322 kinesin-associated protein 3

(term hierarchy)
InterPro Domains

IPR000225 Armadillo

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR008658 Kinesin-associated protein 3

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All nucleic 131

cDNA 131

Microarray probesets 5

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MGD-MRK-36138

Summaries

All 40

Developmental Gene Expression 3

Gene Ontology 7

Phenotypes 12
Earliest

J:34827 Yamazaki H, et al., Cloning and characterization of KAP3: a novel kinesin superfamily-associated protein of KIF3A/3B. Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8443-8
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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