About   Help   FAQ
Kifap3
Gene Detail
 Symbol
Name
ID
Kifap3
kinesin-associated protein 3
MGI:107566
Synonyms KAP3, Smg GDS
Feature Type protein coding gene
Genetic Map
Chromosome 1
71.08 cM, cytoband H1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:163779583-163917109 bp, + strand
From VEGA annotation of GRCm38

  137527 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7799  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Kifap3

Human
homologs
Human Homolog KIFAP3, kinesin-associated protein 3
NCBI Gene ID 22920
neXtProt AC  NX_Q92845
Human Synonyms  dJ190I16.1, FLA3, KAP-1, KAP3, KAP-3, SMAP, Smg-GDS
Human Chr (Location)  1q24.2; chr1:169921329-170074741 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(4) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
About 70% of homozygotes for a knock-out mutation die of heart failure shortly after birth due to massive cardiomyocyte apoptosis triggered by cardiovascular overload. Neonatal thymocytes and developing neuronal cells undergo apoptosis while cultured thymocytes are susceptible to apoptotic inducers.
 
Interactions
Kifap3 interacts with 259 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process microtubule-based process, negative regulation of apoptotic process, ...
Component axoneme, centrosome, ...
Function kinesin binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (101)    Tissues (12)    Images (21)
Theiler Stages: 23
Assay TypeResults
RNA in situ 101
cDNA source data(131)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(131) cDNA(131)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000018234 (Evidence)
Ensembl Gene ModelENSMUSG00000026585 (Evidence)
Entrez Gene16579 (Evidence)
UniGene4651
DFCITC1575227, TC1590317
DoTSDT.101386480, DT.533868, DT.94156218
NIA Mouse Gene IndexU001010
Consensus CDS ProjectCCDS35751.1
International Mouse Knockout Project StatusKifap3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018234 VEGA Gene Model | MGI Sequence Detail 137527 C57BL/6J ±  kb
transcript OTTMUST00000044068 VEGA | MGI Sequence Detail 3946 Not Applicable 
polypeptide OTTMUSP00000019807 VEGA | MGI Sequence Detail 793 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(8) UniProt(3)
Polymorphisms SNPs within 2kb(1054 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000225 Armadillo
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR008658 Kinesin-associated protein 3
Protein Ontology PR:000009322 kinesin-associated protein 3
References (Earliest) J:34827 Yamazaki H, et al., Cloning and characterization of KAP3: a novel kinesin superfamily-associated protein of KIF3A/3B. Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8443-8
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(42)
Other
accession IDs
MGD-MRK-36138

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/23/2014
MGI 5.19
The Jackson Laboratory