Kifap3
Gene Detail

Symbol Name ID

Kifap3 kinesin-associated protein 3 MGI:107566

Synonyms

KAP3, Smg GDS

Feature Type

protein coding gene

Genetic Map

Chromosome 1

71.08 cM, cytoband H1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr1:163779583-163917109 bp, + strand From VEGA annotation of GRCm38   137527 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7799  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Kifap3

Human homologs

Human Homolog		KIFAP3, kinesin-associated protein 3
NCBI Gene ID		22920
neXtProt AC		NX_Q92845
Human Synonyms		dJ190I16.1, FLA3, KAP-1, KAP3, KAP-3, SMAP, Smg-GDS
Human Chr (Location)		1q24.2; chr1:169921329-170074741 (-)  GRCh38

Alleles and phenotypes

All alleles(9) : Gene trapped(4) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 

About 70% of homozygotes for a knock-out mutation die of heart failure shortly after birth due to massive cardiomyocyte apoptosis triggered by cardiovascular overload. Neonatal thymocytes and developing neuronal cells undergo apoptosis while cultured thymocytes are susceptible to apoptotic inducers.

 

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	microtubule-based process, negative regulation of apoptotic process, ...
Component	axoneme, centrosome, ...
Function	kinesin binding, protein binding

External Resources: FuncBase

Expression

Literature Summary: (3 records)

Data Summary: Results (101)    Tissues (12)    Images (21)
Theiler Stages: 23

Assay Type	Results
RNA in situ	101

cDNA source data(131)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(131) cDNA(131)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000018234 (Evidence)
Ensembl Gene Model	ENSMUSG00000026585 (Evidence)
Entrez Gene	16579 (Evidence)
UniGene	4651
DFCI	TC1575227, TC1590317
DoTS	DT.101386480, DT.533868, DT.94156218
NIA Mouse Gene Index	U001010
Consensus CDS Project	CCDS35751.1
International Mouse Knockout Project Status	Kifap3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000018234	VEGA Gene Model | MGI Sequence Detail	137527	C57BL/6J
transcript	OTTMUST00000044068	VEGA | MGI Sequence Detail	3946	Not Applicable
polypeptide	OTTMUSP00000019807	VEGA | MGI Sequence Detail	793	Not Applicable

All sequences(41) RefSeq(8) UniProt(3)

Polymorphisms

SNPs within 2kb(1054 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR000225	Armadillo
InterPro	IPR011989	Armadillo-like helical
InterPro	IPR016024	Armadillo-type fold
InterPro	IPR008658	Kinesin-associated protein 3
Protein Ontology	PR:000009322	kinesin-associated protein 3

References

(Earliest) J:34827 Yamazaki H, et al., Cloning and characterization of KAP3: a novel kinesin superfamily-associated protein of KIF3A/3B. Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8443-8
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(42)

Other accession IDs

MGD-MRK-36138