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Kifap3 Gene Detail
Summary
  • Symbol
    Kifap3
  • Name
    kinesin-associated protein 3
  • Synonyms
    KAP3, Smg GDS
  • Feature Type
    protein coding gene
  • IDs
    MGI:107566
    NCBI Gene: 16579
  • Gene Overview
    MyGene.info: KIFAP3
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr1:163779583-163917109 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      137527 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 71.08 cM, cytoband H1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    KIFAP3, kinesin associated protein 3
  • Vertebrate Orthologs
    9
  • Human Ortholog
    KIFAP3, kinesin associated protein 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    dJ190I16.1, FLA3, KAP-1, KAP3, KAP-3, SMAP, Smg-GDS
  • Links
    NCBI Gene ID: 22920
    neXtProt AC: NX_Q92845
    UniProt: Q92845

  • Chr Location
    1q24.2; chr1:169921329-170074741 (-)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    34 phenotypes from 4 alleles in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
About 70% of homozygotes for a knock-out mutation die of heart failure shortly after birth due to massive cardiomyocyte apoptosis triggered by cardiovascular overload. Neonatal thymocytes and developing neuronal cells undergo apoptosis while cultured thymocytes are susceptible to apoptotic inducers.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    101
  • Tissues
    12
  • cDNA Data
    131
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000018234 VEGA Gene Model | MGI Sequence Detail 137527 C57BL/6J ±  kb
    transcript OTTMUST00000044068 VEGA | MGI Sequence Detail 3946 Not Applicable  
    polypeptide OTTMUSP00000019807 VEGA | MGI Sequence Detail 793 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      1101 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 131
      cDNA 131

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-36138
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 3
      Gene Ontology 10
      Phenotypes 12
    • Earliest
      J:34827 Yamazaki H, et al., Cloning and characterization of KAP3: a novel kinesin superfamily-associated protein of KIF3A/3B. Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8443-8
    • Latest
      J:186168 Galiano MR, et al., A distal axonal cytoskeleton forms an intra-axonal boundary that controls axon initial segment assembly. Cell. 2012 May 25;149(5):1125-39
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    05/15/2018
    MGI 6.12     		The Jackson Laboratory