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Kpnb1 Gene Detail
Summary
  • Symbol
    Kpnb1
  • Name
    karyopherin (importin) beta 1
  • Synonyms
    Impnb
  • Feature Type
    protein coding gene
  • IDs
    MGI:107532
    NCBI Gene: 16211
  • Gene Overview
    MyGene.info: KPNB1
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:97159714-97187881 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 60.95 cM, cytoband D
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    102 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107532
protein coding gene Chr11:97159710-97187892 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019026
protein coding gene Chr11:99550025-99576867 (-)
A/J MGP_AJ_G0018994
protein coding gene Chr11:95474284-95499318 (-)
AKR/J MGP_AKRJ_G0018964
protein coding gene Chr11:98435155-98463137 (-)
BALB/cJ MGP_BALBcJ_G0018967
protein coding gene Chr11:95958459-95986907 (-)
C3H/HeJ MGP_C3HHeJ_G0018781
protein coding gene Chr11:98544631-98574653 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019419
protein coding gene Chr11:102636842-102666030 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017050
protein coding gene Chr11:92931464-92960172 (-)
CAST/EiJ MGP_CASTEiJ_G0018334
protein coding gene Chr11:99396986-99428080 (-)
CBA/J MGP_CBAJ_G0018752
protein coding gene Chr11:106861251-106893036 (-)
DBA/2J MGP_DBA2J_G0018860
protein coding gene Chr11:95024160-95049658 (-)
FVB/NJ MGP_FVBNJ_G0018849
protein coding gene Chr11:94503654-94531806 (-)
LP/J MGP_LPJ_G0018930
protein coding gene Chr11:100077472-100108275 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018876
protein coding gene Chr11:106764717-106793798 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019459
protein coding gene Chr11:98724604-98753025 (-)
PWK/PhJ MGP_PWKPhJ_G0018106
protein coding gene Chr11:95999662-96026538 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017896
protein coding gene Chr11:98455415-98480911 (-)
WSB/EiJ MGP_WSBEiJ_G0018384
protein coding gene Chr11:98636278-98661300 (-)



Homology
more
  • Human Ortholog
    KPNB1, karyopherin subunit beta 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KPNB1, karyopherin subunit beta 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IMB1, Impnb, IPO1, IPOB, NTF97
  • Links
    NCBI Gene ID: 3837
    neXtProt AC: NX_Q14974
    UniProt: Q14974

  • Chr Location
    17q21.32; chr17:47649838-47683638 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1707
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: KPNB1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 3 alleles in 3 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in lethality shortly after implantation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000001440 Ensembl Gene Model | MGI Sequence Detail 28168 C57BL/6J ±  kb
transcript ENSMUST00000001479 Ensembl | MGI Sequence Detail 5894 Not Applicable  
polypeptide ENSMUSP00000001479 Ensembl | MGI Sequence Detail 876 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 717
    cDNA 716
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-36102, MGI:2144006
References
more
  • Summaries
    All 73
    Developmental Gene Expression 5
    Gene Ontology 18
    Phenotypes 17
  • Earliest
    J:34928 Matsuda Y, et al., Localization of the importin-beta gene to mouse chromosome 11D and rat chromosome 10q32.1. Genomics. 1996 15;36(1):213-5
  • Latest
    J:259272 Hervera A, et al., Reactive oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons. Nat Cell Biol. 2018 Mar;20(3):307-319

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory