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Kpnb1
Gene Detail
Symbol

Name
ID
Kpnb1
karyopherin (importin) beta 1
MGI:107532
Synonyms
Impnb
Feature Type
protein coding gene
Genetic Map
Chromosome 11
60.95 cM, cytoband D
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr11:97159714-97187881 bp, - strand
From VEGA annotation of GRCm38

  28168 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1707  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Kpnb1

Human
homologs
Human Homolog KPNB1, karyopherin (importin) beta 1
NCBI Gene ID 3837
neXtProt AC  NX_Q14974
Human Synonyms  IMB1, Impnb, IPO1, IPOB, NTF97
Human Chr (Location)  17q21.32; chr17:47649838-47683638 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(48) : Gene trapped(45) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in lethality shortly after implantation.
 
Interactions
Kpnb1 interacts with 422 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process intracellular protein transport, nucleocytoplasmic transport, ...
Component cell, cytoplasm, ...
Function enzyme binding, poly(A) RNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (39)    Tissues (30)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 14
RNA in situ 19
Western blot 6
cDNA source data(714)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(716) cDNA(715) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000002303 (Evidence)
Ensembl Gene ModelENSMUSG00000001440 (Evidence)
Entrez Gene16211 (Evidence)
UniGene251013
DFCITC1573934, TC1704692
DoTSDT.94362077, DT.536926, DT.97415576
NIA Mouse Gene IndexU033336
PDB1UKL, 1GCJ
Consensus CDS ProjectCCDS25316.1
International Mouse Knockout Project StatusKpnb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002303 VEGA Gene Model | MGI Sequence Detail 28168 C57BL/6J ±  kb
transcript OTTMUST00000004585 VEGA | MGI Sequence Detail 5894 Not Applicable 
polypeptide OTTMUSP00000002199 VEGA | MGI Sequence Detail 876 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(4) UniProt(9)
Polymorphisms
SNPs within 2kb(107 from dbSNP Build 137)    SNPs within 2kb including multiple locations(115)
Protein-related
information
ResourceIDDescription
InterPro IPR011989 Armadillo-like helical
InterPro IPR016024 Armadillo-type fold
InterPro IPR021133 HEAT, type 2
InterPro IPR001494 Importin-beta, N-terminal
InterPro IPR027140 Importin subunit beta
Protein Ontology PR:000009439 importin subunit beta-1
References
(Earliest) J:34928 Matsuda Y, et al., Localization of the importin-beta gene to mouse chromosome 11D and rat chromosome 10q32.1. Genomics. 1996 15;36(1):213-5
(Latest) J:198449 You P, et al., Expression and subcellular distribution of imp13 are regulated in brain development. In Vitro Cell Dev Biol Anim. 2013 May;49(5):346-53
All references(57)
Other
accession IDs
MGD-MRK-36102, MGI:2144006

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory