Ly6a
Gene Detail

Symbol Name ID

Ly6a lymphocyte antigen 6 complex, locus A MGI:107527

Synonyms

Ly-6A.2, Ly-6A/E, Ly-6E.1, Sca1, Sca-1, TAP

Feature Type

protein coding gene

Genetic Map

Chromosome 15

34.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr15:74994878-74997634 bp, - strand From Ensembl annotation of GRCm38   2757 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:113718  Vertebrate Homology Class
7 mouse; 5 rat

Protein SuperFamily: Ly-6-like protein
Gene Tree: Ly6a

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Nullizygous mice show strain-dependent prenatal lethality, altered proliferative response by T lymphocytes, hematopoietic stem cell and progenitor defects, and age-related osteoporosis. Heterozygotes for a knock-in allele develop a myeloproliferative disorder and skin pathology at high penetrance.

 
Human Diseases Modeled Using Mouse Ly6a (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)

Gene Ontology (GO) classifications

All GO classifications: (5 annotations)

Component

anchored to membrane, external side of plasma membrane, ...

External Resources: FuncBase

Expression

Literature Summary: (18 records)
Data Summary: Results (17)    Tissues (11)    Images (9)
Theiler Stages: 15, 23, 28

Assay Type	Results
RNA in situ	15
RT-PCR	2

cDNA source data(198)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(201) Genomic(2) cDNA(198) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000075602 (Evidence)
Entrez Gene	110454 (Evidence)
UniGene	425949
DFCI	TC1574140
DoTS	DT.87061206, DT.94376770, DT.94376780
NIA Mouse Gene Index	U036299
Consensus CDS Project	CCDS27540.1
International Mouse Knockout Project Status	Ly6a

Sequences

Length	Strain/Species
genomic	ENSMUSG00000075602	Ensembl Gene Model | MGI Sequence Detail	2757	C57BL/6J
transcript	ENSMUST00000023248	Ensembl | MGI Sequence Detail	819	Not Applicable
polypeptide	ENSMUSP00000023248	Ensembl | MGI Sequence Detail	134	Not Applicable

All sequences(34) RefSeq(12) UniProt(1)

Polymorphisms

RFLP(1) : SNPs(19 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001526	CD59 antigen
InterPro	IPR018363	CD59 antigen, conserved site
InterPro	IPR016054	Ly-6 antigen / uPA receptor -like
Protein Ontology	PR:000002979	lymphocyte antigen 6A-2/6E-1

References

(Earliest) J:8235 Palfree RG, et al., Ly-6A.2 and Ly-6E.1 molecules are antithetical and identical to MALA-1. Immunogenetics. 1986;23(3):197-207
(Latest) J:193904 Ma F, et al., Isolation of pancreatic progenitor cells with the surface marker of hematopoietic stem cells. Int J Endocrinol. 2012;2012:948683
All references(78)

Other accession IDs

MGD-MRK-36097