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Ly6a
Gene Detail
 Symbol
Name
ID
Ly6a
lymphocyte antigen 6 complex, locus A
MGI:107527
Synonyms Ly-6A.2, Ly-6A/E, Ly-6E.1, Sca1, Sca-1, TAP
Feature Type protein coding gene
Genetic Map
Chromosome 15
34.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:74994878-74997634 bp, - strand
From Ensembl annotation of GRCm38

  2757 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:113718  Vertebrate Homology Class
7 mouse; 6 rat

Protein SuperFamily: Ly-6-like protein
Gene Tree: Ly6a

Alleles
and
phenotypes
All alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Nullizygous mice show strain-dependent prenatal lethality, altered proliferative response by T lymphocytes, hematopoietic stem cell and progenitor defects, and age-related osteoporosis. Heterozygotes for a knock-in allele develop a myeloproliferative disorder and skin pathology at high penetrance.
 
Human Diseases Modeled Using Mouse Ly6a (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Component anchored component of membrane, external side of plasma membrane, ...
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (57)    Tissues (51)    Images (11)
Theiler Stages: 15, 23, 26, 28
Assay TypeResults
RNA in situ 55
RT-PCR 2
cDNA source data(198)
External Resources: GEO   ArrayExpress
Molecular
reagents
All nucleic(201) Genomic(2) cDNA(198) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000075602 (Evidence)
Entrez Gene110454 (Evidence)
UniGene425949
DFCITC1574140
DoTSDT.87061206, DT.94376770, DT.94376780
NIA Mouse Gene IndexU036299
Consensus CDS ProjectCCDS27540.1
International Mouse Knockout Project StatusLy6a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000075602 Ensembl Gene Model | MGI Sequence Detail 2757 C57BL/6J ±  kb
transcript ENSMUST00000023248 Ensembl | MGI Sequence Detail 819 Not Applicable 
polypeptide ENSMUSP00000023248 Ensembl | MGI Sequence Detail 134 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(12) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(62 from dbSNP Build 137)    SNPs within 2kb including multiple locations(100)
Protein-related
information
ResourceIDDescription
InterPro IPR001526 CD59 antigen
InterPro IPR018363 CD59 antigen, conserved site
InterPro IPR016054 Ly-6 antigen / uPA receptor -like
Protein Ontology PR:000002979 lymphocyte antigen 6A-2/6E-1
References (Earliest) J:8235 Palfree RG, et al., Ly-6A.2 and Ly-6E.1 molecules are antithetical and identical to MALA-1. Immunogenetics. 1986;23(3):197-207
(Latest) J:204863 Fogel LA, et al., Markers of nonselective and specific NK cell activation. J Immunol. 2013 Jun 15;190(12):6269-76
All references(82)
Other
accession IDs
MGD-MRK-36097

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory