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Ly6a
Gene Detail
Symbol

Name
ID
Member of
Ly6a
lymphocyte antigen 6 complex, locus A
MGI:107527
Ly6 cluster
Synonyms
Ly-6A.2, Ly-6A/E, Ly-6E.1, Sca1, Sca-1, TAP
Feature Type
protein coding gene
Genetic Map
Chromosome 15
34.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:74994877-74998031 bp, - strand
From VEGA annotation of GRCm38

  3155 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:113718  Vertebrate Homology Class
7 mouse; 6 rat

Protein SuperFamily: Ly-6-like protein
Gene Tree: Ly6a

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Radiation induced(1) Targeted(3)
Genomic Mutations involving Ly6a (1)
Incidental mutations (data from Mutagenetix , APF )
 
Nullizygous mice show strain-dependent prenatal lethality, altered proliferative response by T lymphocytes, hematopoietic stem cell and progenitor defects, and age-related osteoporosis. Heterozygotes for a knock-in allele develop a myeloproliferative disorder and skin pathology at high penetrance.
 
Human Diseases Modeled Using Mouse Ly6a (1)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Interactions
Ly6a interacts with 71 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Component anchored component of membrane, external side of plasma membrane, ...
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (57)    Tissues (51)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 55
RT-PCR 2
cDNA source data(198)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(201) Genomic(2) cDNA(198) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000045110 (Evidence)
Ensembl Gene ModelENSMUSG00000075602 (Evidence)
Entrez Gene110454 (Evidence)
UniGene425949
DFCITC1574140
DoTSDT.94376780, DT.94376770, DT.87061206
NIA Mouse Gene IndexU036299
Consensus CDS ProjectCCDS27540.1
International Mouse Knockout Project StatusLy6a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000045110 VEGA Gene Model | MGI Sequence Detail 3155 C57BL/6J ±  kb
transcript OTTMUST00000118546 VEGA | MGI Sequence Detail 878 Not Applicable 
polypeptide OTTMUSP00000066168 VEGA | MGI Sequence Detail 134 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(12) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(72 from dbSNP Build 137)    SNPs within 2kb including multiple locations(118)
Protein-related
information
ResourceIDDescription
InterPro IPR001526 CD59 antigen
InterPro IPR018363 CD59 antigen, conserved site
InterPro IPR016054 Ly-6 antigen / uPA receptor -like
Protein Ontology PR:000002979 lymphocyte antigen 6A-2/6E-1
References
(Earliest) J:8235 Palfree RG, et al., Ly-6A.2 and Ly-6E.1 molecules are antithetical and identical to MALA-1. Immunogenetics. 1986;23(3):197-207
(Latest) J:208878 Donati G, et al., Epidermal Wnt/beta-catenin signaling regulates adipocyte differentiation via secretion of adipogenic factors. Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):E1501-9
All references(87)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-36097

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory