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Ly6a
Gene Detail
Symbol

Name
ID
Member of
Ly6a
lymphocyte antigen 6 complex, locus A
MGI:107527
Ly6 cluster
Synonyms
Ly-6A.2, Ly-6A/E, Ly-6E.1, Sca1, Sca-1, TAP
Feature Type
protein coding gene
Genetic Map
Chromosome 15
34.29 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:74994877-74998031 bp, - strand
From VEGA annotation of GRCm38

  3155 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:113718  Vertebrate Homology Class
7 mouse; 6 rat

Protein SuperFamily: Ly-6-like protein
Gene Tree: Ly6a

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Radiation induced(1) Targeted(3)
Genomic Mutations involving Ly6a (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Nullizygous mice show strain-dependent prenatal lethality, altered proliferative response by T lymphocytes, hematopoietic stem cell and progenitor defects, and age-related osteoporosis. Heterozygotes for a knock-in allele develop a myeloproliferative disorder and skin pathology at high penetrance.
 
Human Diseases Modeled in Mice Using Ly6a (1)    Mutations Annotated to Human Diseases (1)    Phenotype Images(3)
Interactions
Ly6a interacts with 70 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (5 annotations)
Component anchored component of membrane, external side of plasma membrane, ...
External Resources: FuncBase
Expression
Literature Summary: (22 records)
Data Summary: Results (57)    Tissues (51)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 55
RT-PCR 2
cDNA source data(198)
Other mouse links: GEO   Expression Atlas
Molecular
reagents
All nucleic(201) Genomic(2) cDNA(198) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000045110 (Evidence)
Ensembl Gene Model ENSMUSG00000075602 (Evidence)
Entrez Gene 110454 (Evidence)
UniGene 425949
DFCI TC1574140
DoTS DT.87061206, DT.94376770, DT.94376780
NIA Mouse Gene Index U036299
Consensus CDS Project CCDS27540.1
International Mouse Phenotyping Consortium Status Ly6a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000045110 VEGA Gene Model | MGI Sequence Detail 3155 C57BL/6J ±  kb
transcript OTTMUST00000118549 VEGA | MGI Sequence Detail 862 Not Applicable 
polypeptide OTTMUSP00000066171 VEGA | MGI Sequence Detail 134 Not Applicable 

For the selected sequences
All sequences(56) RefSeq(12) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(72 from dbSNP Build 137)    SNPs within 2kb including multiple locations(118)
Protein-related
information
ResourceIDDescription
InterPro IPR001526 CD59 antigen
InterPro IPR018363 CD59 antigen, conserved site
InterPro IPR016054 Ly-6 antigen / uPA receptor -like
Protein Ontology PR:000002979 lymphocyte antigen 6A-2/6E-1
References
(Earliest) J:8235 Palfree RG, et al., Ly-6A.2 and Ly-6E.1 molecules are antithetical and identical to MALA-1. Immunogenetics. 1986;23(3):197-207
(Latest) J:220476 Walter D, et al., Exit from dormancy provokes DNA-damage-induced attrition in haematopoietic stem cells. Nature. 2015 Apr 23;520(7548):549-52
All references(89)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-36097

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory