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Ly6a Gene Detail
Summary
  • Symbol
    Ly6a
  • Name
    lymphocyte antigen 6 complex, locus A
  • Synonyms
    Ly-6A.2, Ly-6A/E, Ly-6E.1, Sca1, Sca-1, TAP
  • Feature Type
    protein coding gene
  • IDs
    MGI:107527
    NCBI Gene: 110454
  • Member of
    Ly6 cluster
Location & Maps
more
  • Sequence Map
    Chr15:74994877-74998031 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3155 bp   ±  kb flank

  • Genome Browsers
Homology
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Human Diseases
more
  • Diseases
    1 with Ly6a mouse models

Human Disease Mouse Models
       Osteoporosis   OMIM: 166710 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    38 phenotypes from 3 alleles in 5 genetic backgrounds
    3 phenotypes from multigenic genotypes
    1 images
    42 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    3
  • Radiation induced
    2
  • Targeted
    3
  • Genomic Mutations
    5 involving Ly6a
  • Incidental Mutations
Nullizygous mice show strain-dependent prenatal lethality, altered proliferative response by T lymphocytes, hematopoietic stem cell and progenitor defects, and age-related osteoporosis. Heterozygotes for a knock-in allele develop a myeloproliferative disorder and skin pathology at high penetrance.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000045110 VEGA Gene Model | MGI Sequence Detail 3155 C57BL/6J ±  kb
transcript OTTMUST00000118546 VEGA | MGI Sequence Detail 878 Not Applicable  
polypeptide OTTMUSP00000066168 VEGA | MGI Sequence Detail 134 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    68 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000002979 lymphocyte antigen 6A-2/6E-1
  • InterPro Domains
    IPR018363 CD59 antigen, conserved site
    IPR016054 Ly-6 antigen/uPA receptor-like
Molecular
Reagents
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  • All nucleic 201
    Genomic 2
    cDNA 198
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-36097
References
more
  • Summaries
    All 89
    Developmental Gene Expression 25
    Diseases 2
    Gene Ontology 10
    Phenotypes 42
  • Earliest
    J:8235 Palfree RG, et al., Ly-6A.2 and Ly-6E.1 molecules are antithetical and identical to MALA-1. Immunogenetics. 1986;23(3):197-207
  • Latest
    J:228583 Nandadasa S, et al., ADAMTS9-Mediated Extracellular Matrix Dynamics Regulates Umbilical Cord Vascular Smooth Muscle Differentiation and Rotation. Cell Rep. 2015 Jun 16;11(10):1519-28

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory