Stil
Gene Detail

Symbol Name ID

Stil Scl/Tal1 interrupting locus MGI:107477

Synonyms

Sil

Feature Type

protein coding gene

Genetic Map

Chromosome 4

52.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr4:115000159-115043196 bp, + strand From VEGA annotation of GRCm38   43038 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2283  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Stil

Human homologs

Human Homolog		STIL, SCL/TAL1 interrupting locus
NCBI Gene ID		6491
neXtProt AC		NX_Q15468
Human Synonyms		MCPH7, SIL
Human Chr (Location)		1p32; chr1:47715811-47779819 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human STIL

Alleles and phenotypes

All alleles(5) : Targeted(3) Gene trapped(2)
 

Mice homozygous for disruptions in this gene die as embryos with various neural tube defects.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	determination of left/right symmetry, embryonic axis specification, ...
Component	centrosome, cytoplasm

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (106)    Tissues (104)    Images (14)
Theiler Stages: 15, 19, 22, 28

Assay Type	Results
RNA in situ	93
Northern blot	10
Western blot	3

cDNA source data(66)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(69) cDNA(68) Primer pair(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000008583 (Evidence)
Ensembl Gene Model	ENSMUSG00000028718 (Evidence)
Entrez Gene	20460 (Evidence)
UniGene	3988
DFCI	TC1580524, TC1612441, TC1623634, TC1643616
DoTS	DT.101734930, DT.102525872, DT.528461, DT.91321927
NIA Mouse Gene Index	U004663, U004664
Consensus CDS Project	CCDS18485.1
International Mouse Knockout Project Status	Stil

Sequences

Length	Strain/Species
genomic	OTTMUSG00000008583	VEGA Gene Model | MGI Sequence Detail	43038	C57BL/6J
transcript	OTTMUST00000019459	VEGA | MGI Sequence Detail	5285	Not Applicable
polypeptide	OTTMUSP00000008928	VEGA | MGI Sequence Detail	1262	Not Applicable

All sequences(58) RefSeq(2) UniProt(7)

Polymorphisms

SNPs(280 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR026123	SCL-interrupting locus protein
Protein Ontology	PR:000015735	SCL-interrupting locus protein

References

(Earliest) J:30658 Aplan PD, et al., Structural characterization of SIL, a gene frequently disrupted in T-cell acute lymphoblastic leukemia. Mol Cell Biol. 1991 Nov;11(11):5462-9
(Latest) J:182879 Castiel A, et al., The Stil protein regulates centrosome integrity and mitosis through suppression of Chfr. J Cell Sci. 2011 Feb 15;124(Pt 4):532-9
All references(39)

Other accession IDs

MGD-MRK-36044