About   Help   FAQ
Stil
Gene Detail
Symbol

Name
ID
Stil
Scl/Tal1 interrupting locus
MGI:107477
Synonyms
Sil
Feature Type
protein coding gene
Genetic Map
Chromosome 4
52.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:115000159-115043203 bp, + strand
From VEGA annotation of GRCm38

  43045 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2283  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: STIL
Gene Tree: Stil

Human
homologs
STIL, SCL/TAL1 interrupting locus
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 6491
neXtProt AC: NX_Q15468

Human Synonyms: MCPH7, SIL

Human Chr (Location): 1p32; chr1:47250139-47314781 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human STIL

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Genomic Mutations involving Stil (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions in this gene die as embryos with various neural tube defects.
 
Interactions
Stil interacts with 387 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process centrosome duplication, cilium morphogenesis, ...
Component centriole, centrosome, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (106)    Tissues (104)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 93
Northern blot 10
Western blot 3
cDNA source data(66)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA STIL ; Xenbase stil ; ZFIN stil    NEW 
Molecular
reagents
All nucleic(69) cDNA(68) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000008583 (Evidence)
Ensembl Gene Model ENSMUSG00000028718 (Evidence)
Entrez Gene 20460 (Evidence)
UniGene 3988
DFCI TC1580524, TC1643616, TC1623634, TC1612441
DoTS DT.102525872, DT.101734930, DT.528461, DT.91321927
NIA Mouse Gene Index U004664, U004663
Consensus CDS Project CCDS18485.1
International Mouse Phenotyping Consortium Status Stil
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008583 VEGA Gene Model | MGI Sequence Detail 43045 C57BL/6J ±  kb
transcript OTTMUST00000019459 VEGA | MGI Sequence Detail 5285 Not Applicable 
polypeptide OTTMUSP00000008928 VEGA | MGI Sequence Detail 1262 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(16) UniProt(7)
Polymorphisms
SNPs within 2kb(317 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026123 SCL-interrupting locus protein
Protein Ontology PR:000015735 SCL-interrupting locus protein
References
(Earliest) J:30658 Aplan PD, et al., Structural characterization of SIL, a gene frequently disrupted in T-cell acute lymphoblastic leukemia. Mol Cell Biol. 1991 Nov;11(11):5462-9
(Latest) J:197278 Vulprecht J, et al., STIL is required for centriole duplication in human cells. J Cell Sci. 2012 Mar 1;125(Pt 5):1353-62
All references(39)
Other
accession IDs
MGD-MRK-36044

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2015
MGI 5.22
The Jackson Laboratory