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Stil
Gene Detail
Symbol

Name
ID
Stil
Scl/Tal1 interrupting locus
MGI:107477
Synonyms
Sil
Feature Type
protein coding gene
Genetic Map
Chromosome 4
52.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:115000159-115043196 bp, + strand
From VEGA annotation of GRCm38

  43038 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2283  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Stil

Human
homologs
Human Homolog STIL, SCL/TAL1 interrupting locus
NCBI Gene ID 6491
neXtProt AC  NX_Q15468
Human Synonyms  MCPH7, SIL
Human Chr (Location)  1p32; chr1:47250139-47314147 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human STIL
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(2) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene die as embryos with various neural tube defects.
 
Interactions
Stil interacts with 388 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process centrosome duplication, cilium morphogenesis, ...
Component centriole, centrosome, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (106)    Tissues (104)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 93
Northern blot 10
Western blot 3
cDNA source data(66)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(69) cDNA(68) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000008583 (Evidence)
Ensembl Gene ModelENSMUSG00000028718 (Evidence)
Entrez Gene20460 (Evidence)
UniGene3988
DFCITC1612441, TC1580524, TC1643616, TC1623634
DoTSDT.102525872, DT.101734930, DT.528461, DT.91321927
NIA Mouse Gene IndexU004664, U004663
Consensus CDS ProjectCCDS18485.1
International Mouse Knockout Project StatusStil
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008583 VEGA Gene Model | MGI Sequence Detail 43038 C57BL/6J ±  kb
transcript OTTMUST00000019459 VEGA | MGI Sequence Detail 5285 Not Applicable 
polypeptide OTTMUSP00000008928 VEGA | MGI Sequence Detail 1262 Not Applicable 

For the selected sequences
All sequences(75) RefSeq(14) UniProt(12)
Polymorphisms
SNPs within 2kb(316 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026123 SCL-interrupting locus protein
Protein Ontology PR:000015735 SCL-interrupting locus protein
References
(Earliest) J:30658 Aplan PD, et al., Structural characterization of SIL, a gene frequently disrupted in T-cell acute lymphoblastic leukemia. Mol Cell Biol. 1991 Nov;11(11):5462-9
(Latest) J:197278 Vulprecht J, et al., STIL is required for centriole duplication in human cells. J Cell Sci. 2012 Mar 1;125(Pt 5):1353-62
All references(40)
Other
accession IDs
MGD-MRK-36044

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory