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Stil Gene Detail
Summary
  • Symbol
    Stil
  • Name
    Scl/Tal1 interrupting locus
  • Synonyms
    Sil
  • Feature Type
    protein coding gene
  • IDs
    MGI:107477
    NCBI Gene: 20460
  • Gene Overview
    MyGene.info: STIL
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr4:115000159-115043196 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      43038 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 52.73 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    STIL, STIL, centriolar assembly protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    STIL, STIL, centriolar assembly protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MCPH7, SIL
  • Links
    NCBI Gene ID: 6491
    neXtProt AC: NX_Q15468
    UniProt: Q15468

  • Chr Location
    1p33; chr1:47250139-47314787 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 2283
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: STIL
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human STIL associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene die as embryos with various neural tube defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000008583 VEGA Gene Model | MGI Sequence Detail 43038 C57BL/6J ±  kb
    transcript OTTMUST00000019459 VEGA | MGI Sequence Detail 5285 Not Applicable  
    polypeptide OTTMUSP00000008928 VEGA | MGI Sequence Detail 1262 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      315 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      8 Sequences
    • InterPro Domains
      IPR026123 SCL-interrupting locus protein
    Molecular
    Reagents
    less
    • All nucleic 69
      cDNA 68
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36044
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 5
      Gene Ontology 5
      Phenotypes 13
    • Earliest
      J:30658 Aplan PD, et al., Structural characterization of SIL, a gene frequently disrupted in T-cell acute lymphoblastic leukemia. Mol Cell Biol. 1991 Nov;11(11):5462-9
    • Latest
      J:197278 Vulprecht J, et al., STIL is required for centriole duplication in human cells. J Cell Sci. 2012 Mar 1;125(Pt 5):1353-62

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory